{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:11:49Z","timestamp":1793643109668,"version":"4.5.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jped.2021.02.007","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T09:02:48Z","timestamp":1616576568000},"page":"595-602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth hormone deficiency and the transition from pediatric to adult care"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-246X","authenticated-orcid":false,"given":"Ana Beatriz Winter","family":"Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-8520","authenticated-orcid":false,"given":"Paulo Ferrez","family":"Collett-Solberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2021.02.007_bib0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/eje.1.01829","article-title":"Consensus statement on the management of the GH-treated adolescent in the transition to adult care","volume":"152","author":"Clayton","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ecl.2006.11.002","article-title":"Growth hormone and the transition from puberty into adulthood","volume":"36","author":"Attanasio","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jped.2021.02.007_bib0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1210\/edrv.22.4.0438","article-title":"Optimizing GH therapy in adults and children","volume":"22","author":"Drake","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jped.2021.02.007_bib0020","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Molitch","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0025","first-page":"1195","article-title":"Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGFI) and IGF-binding protein-3","volume":"82","author":"Juul","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-2265.1996.671492.x","article-title":"The prevalence of severe growth hormone deficiency in adults who received growth hormone replacement in childhood","volume":"44","author":"Nicolson","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jped.2021.02.007_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ghir.2018.12.004","article-title":"Growth hormone therapy in children; research and practice \u2014 a review","volume":"44","author":"Solberg","year":"2019","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0040","article-title":"Adult growth hormone deficiency: optimizing transition of care from pediatric to adult services","volume":"56","author":"Yuen","year":"2020","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0045","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","article-title":"Guidelines for growth hormone and insulin-like growth factor I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency","volume":"86","author":"Grimberg","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jped.2021.02.007_bib0050","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1210\/jcem.86.10.7897","article-title":"GH is needed for the maturation of muscle mass and strength in adolescents","volume":"86","author":"Hulthen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0055","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1515\/jpem-2000-s604","article-title":"Growth hormone deficiency and peak bone mass","volume":"13","author":"Bouillon","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0060","first-page":"3951","article-title":"Hormonal determinants and disorders of peak bone mass in children","volume":"85","author":"Soyka","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0065","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4158\/EP11168.RA","article-title":"Transition care of patients with growth hormone deficiency from pediatric endocrinologists to adult endocrinologists","volume":"18","author":"Shea","year":"2012","journal-title":"Endocr Pract"},{"key":"10.1016\/j.jped.2021.02.007_bib0070","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1172\/JCI117034","article-title":"Timing of peak bone mass in Caucasian females and its implications for the prevention of osteoporosis: interference from a cross-sectional model","volume":"93","author":"Matkovic","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jped.2021.02.007_bib0075","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1210\/jcem.86.10.7897","article-title":"GH is needed for the maturation of muscle mass and strength in adolescents","volume":"86","author":"Hulthen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0080","first-page":"3890","article-title":"Long term prospective study of body composition and lipid profiles during and after growth hormone (GH) treatment in children with GH deficiency: gender-specific metabolic effects","volume":"83","author":"Kuromaru","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1515\/jpem-2017-0098","article-title":"Impact of discontinuation of growth hormone treatment on lipids and weight status in adolescents","volume":"30","author":"Rothermel","year":"2017","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0090","first-page":"364","article-title":"Bone mineral density and body composition in adolescents with childhood-onset growth hormone deficiency","volume":"71","author":"Boot","year":"2009","journal-title":"Horm Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0095","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/EJE-08-0436","article-title":"Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency","volume":"160","author":"Conway","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11102-008-0101-y","article-title":"Transitioning of children with GH deficiency to adult dosing: changes in body composition","volume":"12","author":"Nguyen","year":"2009","journal-title":"Pituitary"},{"key":"10.1016\/j.jped.2021.02.007_bib0105","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1210\/jc.2003-030204","article-title":"Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study","volume":"88","author":"Underwood","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0110","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1210\/jcem.87.8.8777","article-title":"The cardiovascular risk of the GH-deficient adolescents","volume":"87","author":"Colao","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0115","first-page":"4516","article-title":"Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects","volume":"84","author":"Johannsson","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jocd.2011.05.001","article-title":"Early chances in body composition after cessation of growth hormone therapy in childhood-onset growth hormone deficiency","volume":"14","author":"Betchtold","year":"2011","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.jped.2021.02.007_bib0125","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1210\/jc.2009-2013","article-title":"Discontinuation of growth hormone (GH) treatment during transition phase is an important factor determining the phenotype of young adults with non-idiopathic childhood-onset GH deficiency","volume":"95","author":"Koltowska-H\u00e4ggstr\u00f6m","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ecl.2016.01.005","article-title":"Cardiovascular risk in growth hormone deficiency \u2014 beneficial effects of growth hormone replacement therapy","volume":"45","author":"Lanes","year":"2016","journal-title":"Endocrinol Metab Clin N Am"},{"key":"10.1016\/j.jped.2021.02.007_bib0135","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1210\/jc.2004-0551","article-title":"Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients","volume":"89","author":"Attanasio","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0140","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1210\/jc.2005-0091","article-title":"Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters","volume":"90","author":"Lanes","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0145","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1210\/jcem.86.3.7268","article-title":"Cardiac mass and function, carotid artery intima-media thickness and lipoprotein levels in growth hormone deficient adolescents","volume":"86","author":"Lanes","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0150","first-page":"1329","article-title":"Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency","volume":"84","author":"Borson-Chazot","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0155","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1210\/jc.2003-030126","article-title":"Effect of growth hormone (GH) treatment on bone in postpubertal GH-deficient patients: a 2-year randomized, controlled, dose-ranging study","volume":"88","author":"Shalet","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0160","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1210\/jc.2002-021541","article-title":"The effect of cessation of growth hormone (GH) therapy on bone mineral accretion in GH-deficient adolescents at the completion of linear growth","volume":"88","author":"Drake","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2265.2003.01949.x","article-title":"Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD","volume":"60","author":"Baroncelli","year":"2004","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0170","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/EJE-08-0436","article-title":"Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency","volume":"160","author":"Conway","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/eje.0.1420549","article-title":"Dynamics of bone turnover in children with GH deficiency treated with GH until final height","volume":"142","author":"Baroncelli","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/EJE-18-0711","article-title":"Bone microarchitecture and volumetric bone density impairment in young male adults with childhood-onset growth hormone deficiency","volume":"180","author":"Yang","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0185","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ghir.2013.12.001","article-title":"Impact of the growth hormone replacement on bone status in growth hormone deficient adults","volume":"24","author":"Ku\u017ema","year":"2014","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0190","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1210\/jc.2005-0439","article-title":"Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood","volume":"90","author":"Attanasio","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0195","series-title":"Post-treatment follow-up of growth hormone deficient patients: psychosocial status","first-page":"83","author":"Clopper","year":"1996"},{"key":"10.1016\/j.jped.2021.02.007_bib0200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1651-2227.1994.tb13278.x","article-title":"Psychosocial adjustment in a large cohort of adults with growth hormone deficiency treated with growth hormone in childhood: summary of a questionnaire survey","volume":"399","author":"Takano","year":"1994","journal-title":"Acta Paediatr Suppl"},{"key":"10.1016\/j.jped.2021.02.007_bib0205","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1515\/JPEM.2000.13.4.409","article-title":"Psychosocial outcome in growth hormone deficient patients diagnosed during childhood","volume":"13","author":"Keselman","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0210","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0306-4530(02)00045-8","article-title":"Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy","volume":"28","author":"Stouthart","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jped.2021.02.007_bib0215","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1530\/EJE-08-0279","article-title":"Cognition in the adult with childhood-onset GH deficiency","volume":"159","author":"van Nieuwpoort","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0220","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4158\/GL-2019-0405","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care 2019 \u2014 AACE growth hormone task force","volume":"25","author":"Yuen","year":"2019","journal-title":"Endocr Pract"},{"key":"10.1016\/j.jped.2021.02.007_bib0225","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1096-6374(02)00045-X","article-title":"Diagnosis and management of growth hormone deficiency in childhood and adolescence \u2014 Part 2: growth hormone treatment in growth hormone deficient children","volume":"12","author":"Tanaka","year":"2002","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2013.00034","article-title":"The challenge of growth hormone deficiency diagnosis and treatment during the transition from puberty into adulthood","volume":"4","author":"Inzaghi","year":"2013","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0235","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2147\/TCRM.S136576","article-title":"Childhood-onset growth hormone deficiency and the transition to adulthood: current perspective","volume":"14","author":"Ahmid","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jped.2021.02.007_bib0240","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1210\/jc.2007-0167","article-title":"Approach to the growth hormone-deficient child during transition to adulthood","volume":"92","author":"Radovick","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0245","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1210\/jc.2018-00665","article-title":"Macimorelin as a diagnostic test for adult growth hormone deficiency","volume":"103","author":"Garcia","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ghir.2014.11.002","article-title":"Potential risks of glucagon stimulation test in the elderly people","volume":"25","author":"Tavares","year":"2015","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jped.2021.02.007_bib0255","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4158\/EP161407.DSCR","volume":"22","author":"Yuen","year":"2016","journal-title":"Endocr Pract"},{"key":"10.1016\/j.jped.2021.02.007_bib0260","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2265.2001.01169.x","article-title":"An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion inpatients with hypothalamic-pituitary disease","volume":"54","author":"Leong","year":"2001","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0265","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/eje.0.1430099","article-title":"Interaction between glucagon and human corticotropin-releasing hormone or vasopressin on ACTH and cortisol secretion in humans","volume":"143","author":"Arvat","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2021.02.007_bib0270","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1210\/jc.2005-0721","volume":"90","author":"Cianfarani","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0275","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in Hypopituitarism in adults: an Endocrine Clinical Society Guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2021.02.007_bib0280","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/eje.1.02118","article-title":"Body composition during GH replacement in adults \u2014 methodological variations with respect to gender","volume":"154","author":"Koranyi","year":"2006","journal-title":"Eur J Endocrinol"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755721000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755721000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:04:45Z","timestamp":1762185885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755721000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0021755721000541"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2021.02.007","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth hormone deficiency and the transition from pediatric to adult care","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2021.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}