{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:32:03Z","timestamp":1790404323518,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jped.2022.07.004","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T22:29:35Z","timestamp":1661639375000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-5953","authenticated-orcid":false,"given":"Wendell C.","family":"Bila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-4689","authenticated-orcid":false,"given":"M\u00e1rcia C.C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-4062","authenticated-orcid":false,"given":"Luciana L.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-0266","authenticated-orcid":false,"given":"Valmin R.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-8589","authenticated-orcid":false,"given":"Fl\u00e1vio D.","family":"Capanema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-4669","authenticated-orcid":false,"given":"Karina","family":"Pfrimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-2451","authenticated-orcid":false,"given":"Eduardo","family":"Ferriolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-7549","authenticated-orcid":false,"given":"Nat\u00e1lia M.C.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-0096","authenticated-orcid":false,"given":"Cezen\u00e1rio G.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-2875","authenticated-orcid":false,"given":"Fabi\u00e2ngelo M.","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-0867","authenticated-orcid":false,"given":"Maria E.S.M.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-3217","authenticated-orcid":false,"given":"Joel A.","family":"Lamounier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2022.07.004_bib0001","series-title":"Pontos de corte de vari\u00e1veis antropom\u00e9tricas e aptid\u00e3o f\u00edsica aer\u00f3bica para predi\u00e7\u00e3o do agrupamento de fatores de risco de doen\u00e7as cardiovasculares em crian\u00e7as [Tese de doutorado]","author":"Gon\u00e7alves","year":"2011"},{"key":"10.1016\/j.jped.2022.07.004_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0145984","article-title":"Gender-dependent association of FTO polymorphisms with body mass index in Mexicans","volume":"11","author":"Salda\u00f1a-Alvarez","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jped.2022.07.004_bib0003","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.bbadis.2014.01.017","article-title":"The fat mass and obesity-associated (FTO) gene: obesity and beyond?","volume":"1842","author":"Hess","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jped.2022.07.004_bib0004","series-title":"WHO AnthroPlus for personal computers manual: software for assessing growth of the world's children and adolescents","author":"Bl\u00f6ssner","year":"2009"},{"key":"10.1016\/j.jped.2022.07.004_bib0005","series-title":"S\u00edndrome metab\u00f3lica e fatores associados em adolescentes de escolas p\u00fablicas de Divin\u00f3polis, Minas Gerais [Disserta\u00e7\u00e3o de mestrado]","author":"Morais","year":"2016"},{"key":"10.1016\/j.jped.2022.07.004_bib0006","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1590\/S1415-52732004000200010","article-title":"[Obesity and metabolic syndrome in infancy and adolescence]","volume":"17","author":"Oliveira","year":"2004","journal-title":"Rev Nutr"},{"key":"10.1016\/j.jped.2022.07.004_bib0007","series-title":"Diretrizes brasileiras de hipertens\u00e3o VI","year":"2010"},{"key":"10.1016\/j.jped.2022.07.004_bib0008","series-title":"Growth at adolescence","author":"Tanner","year":"1962"},{"key":"10.1016\/j.jped.2022.07.004_bib0009","first-page":"43","article-title":"Fidedignidade do question\u00e1rio puberal simplificado de Cameron","volume":"20","author":"Machado","year":"2012","journal-title":"R Bras Ci e Mov"},{"key":"10.1016\/j.jped.2022.07.004_bib0010","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/ajcn\/82.3.538","article-title":"Comparison of isotope dilution with bioimpdedance spectroscopy and anthropometry for assessment of body composition in asymptomatic HIV-infected and HIV-uninfected breastfeeding mothers","volume":"82","author":"Papathakis","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jped.2022.07.004_bib0011","first-page":"73","article-title":"Body composition in obese adolescents: deuterium oxide dilution method, bioelectrical impedance and predictive equations","volume":"9","author":"Resende","year":"2013","journal-title":"Curr Nutr Food Sci"},{"key":"10.1016\/j.jped.2022.07.004_bib0012","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.jped.2022.07.004_bib0013","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1210\/jc.2007-2343","article-title":"The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks","volume":"93","author":"L\u00f3pez-Bermejo","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2022.07.004_bib0014","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/S1517-86922005000200011","article-title":"Reproducibility and validity of the International Physical Activity Questionnaire in adolescents","volume":"11","author":"Guedes","year":"2005","journal-title":"Rev Bras Med Esporte"},{"key":"10.1016\/j.jped.2022.07.004_bib0015","series-title":"Associa\u00e7\u00e3o Brasileira de Empresas de Pesquisa. Crit\u00e9rio de classifica\u00e7\u00e3o econ\u00f4mica Brasil","year":"2014"},{"key":"10.1016\/j.jped.2022.07.004_bib0016","series-title":"Fisiologia do esporte e do exerc\u00edcio","author":"Wilmore","year":"2010"},{"key":"10.1016\/j.jped.2022.07.004_bib0017","doi-asserted-by":"crossref","first-page":"164","DOI":"10.70252\/XGRF9788","article-title":"Validity of borg ratings of perceived exertion during active video game play","volume":"6","author":"Pollock","year":"2013","journal-title":"Int J Exerc Sci"},{"key":"10.1016\/j.jped.2022.07.004_bib0018","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/ahg.12006","article-title":"Genomic signatures of a global fitness index in a multi-ethnic cohort of women","volume":"77","author":"Rampersaud","year":"2013","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.jped.2022.07.004_bib0019","first-page":"31","article-title":"Precision of 1-RM prediction equations in non-competitive subjects performing strength training","volume":"6","author":"Lacio","year":"2010","journal-title":"Motricidade"},{"key":"10.1016\/j.jped.2022.07.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3134026","article-title":"FTO rs9939609 does not interact with physical exercise but influences basal insulin metabolism in Brazilian overweight and obese adolescents","volume":"2018","author":"do Nascimento","year":"2018","journal-title":"J Obes"},{"key":"10.1016\/j.jped.2022.07.004_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2350-9-85","article-title":"Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents","volume":"9","author":"M\u00fcller","year":"2008","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.jped.2022.07.004_bib0022","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ijo.2012.14","article-title":"The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients","volume":"37","author":"Woehning","year":"2013","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2022.07.004_bib0023","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1001\/archpediatrics.2010.29","article-title":"Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents- the HELENA study","volume":"164","author":"Ruiz","year":"2010","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jped.2022.07.004_bib0024","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ijo.2008.258","article-title":"Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins","volume":"33","author":"Mustelin","year":"2009","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2022.07.004_bib0025","first-page":"4569","article-title":"Effect of exercise combined with dietary intervention on obese children and adolescents associated with the FTO rs9939609 polymorphism","volume":"19","author":"Zou","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jped.2022.07.004_bib0026","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s13679-015-0143-1","article-title":"The \u2018Fat Mass and Obesity Related\u2019 (FTO) gene: mechanisms of impact on obesity and energy balance","volume":"4","author":"Speakman","year":"2015","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.jped.2022.07.004_bib0027","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1093\/nar\/gkx778","article-title":"N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3\u2032-end processing","volume":"45","author":"Bartosovic","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jped.2022.07.004_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2011.00004","article-title":"FTO biology and obesity: why do a billion of us weigh 3 kg more?","volume":"2","author":"Cheung","year":"2011","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jped.2022.07.004_bib0029","series-title":"Methods in Human Growth Research","first-page":"108","article-title":"Measuring maturity","author":"Cameron","year":"2004"},{"key":"10.1016\/j.jped.2022.07.004_bib0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7322\/jhgd.127411","article-title":"Maturational stages: comparison of growth and physical capacity indicators in adolescents","volume":"28","author":"Pinto","year":"2018","journal-title":"J Hum Growth Dev"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755722000912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755722000912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:05:04Z","timestamp":1762185904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755722000912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0021755722000912"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2022.07.004","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2022.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}