{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:51:47Z","timestamp":1778824307858,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/03333-6"],"award-info":[{"award-number":["2015\/03333-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/07143-2"],"award-info":[{"award-number":["2017\/07143-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/17824-0"],"award-info":[{"award-number":["2018\/17824-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/19638-9"],"award-info":[{"award-number":["2018\/19638-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["145350\/2018-5"],"award-info":[{"award-number":["145350\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jped.2022.11.009","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:29:23Z","timestamp":1671755363000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal plasma transforming growth factor-\u03b21 (TGF-\u03b21) and newborn size: the Araraquara Cohort Study"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-1572","authenticated-orcid":false,"given":"Naiara Naiana","family":"Dejani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-5786","authenticated-orcid":false,"given":"Carolina F.","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-1158","authenticated-orcid":false,"given":"Perla Pizzi","family":"Argentato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-2691","authenticated-orcid":false,"given":"Ludmilla da Silva","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-6279","authenticated-orcid":false,"given":"Amanda Correia","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-9461","authenticated-orcid":false,"given":"Let\u00edcia Montanha","family":"de Assis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-7380","authenticated-orcid":false,"given":"Patr\u00edcia Yury","family":"Nakandakare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-1776","authenticated-orcid":false,"given":"L\u00edvia Patricia Rodrigues","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-0989","authenticated-orcid":false,"given":"La\u00edsla de Fran\u00e7a da Silva","family":"Teles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-1272","authenticated-orcid":false,"given":"Maria Paula","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-1398","authenticated-orcid":false,"given":"Liania Alves","family":"Luzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-3647","authenticated-orcid":false,"given":"Alexandra Ivo","family":"de Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-6393","authenticated-orcid":false,"given":"Patr\u00edcia Helen","family":"Rond\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2022.11.009_bib0001","first-page":"158","article-title":"Fetal origins of adult disease","volume":"41","author":"Calkins","year":"2011","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"key":"10.1016\/j.jped.2022.11.009_bib0002","first-page":"199","article-title":"The Barker hypothesis: how pediatricians will diagnose and prevent common adult-onset diseases","volume":"120","author":"Dover","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1016\/j.jped.2022.11.009_bib0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cen.12055","article-title":"The risk of maternal obesity to the long-term health of the offspring","volume":"78","author":"O'Reilly","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.jped.2022.11.009_bib0004","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-0378(02)00085-2","article-title":"Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction","volume":"59","author":"Tjoa","year":"2003","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jped.2022.11.009_bib0005","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0071","article-title":"The role of the maternal immune system in the regulation of human birthweight","volume":"370","author":"Moffett","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.jped.2022.11.009_bib0006","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3945\/jn.115.224279","article-title":"Adiposity and chronic inflammation in young women predict inflammation during normal pregnancy in the philippines","volume":"146","author":"McDade","year":"2016","journal-title":"J Nutr"},{"key":"10.1016\/j.jped.2022.11.009_bib0007","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cyto.2010.11.005","article-title":"Longitudinal modulation of immune system cytokine profile during pregnancy","volume":"53","author":"Denney","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.jped.2022.11.009_bib0008","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fphys.2016.00012","article-title":"Placental responses to changes in the maternal environment determine fetal growth","volume":"7","author":"Dimasuay","year":"2016","journal-title":"Front Physiol"},{"key":"10.1016\/j.jped.2022.11.009_bib0009","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/ijpo.12187","article-title":"The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn","volume":"13","author":"McCloskey","year":"2018","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.jped.2022.11.009_bib0010","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.psyneuen.2018.11.018","article-title":"Beyond the HPA-axis: exploring maternal prenatal influences on birth outcomes and stress reactivity","volume":"101","author":"Nazzari","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jped.2022.11.009_bib0011","doi-asserted-by":"crossref","first-page":"e23245","DOI":"10.1002\/ajhb.23245","article-title":"Regulation of inflammation during gestation and birth outcomes: inflammatory cytokine balance predicts birth weight and length","volume":"31","author":"Ragsdale","year":"2019","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.jped.2022.11.009_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2019.102623","article-title":"Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study","volume":"137","author":"Yeates","year":"2020","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jped.2022.11.009_bib0013","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/osp4.47","article-title":"Tumor necrosis factor-alpha levels in blood cord is directly correlated with the body weight of mothers","volume":"2","author":"de Toledo Baldi","year":"2016","journal-title":"Obes Sci Pract"},{"key":"10.1016\/j.jped.2022.11.009_bib0014","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/jrf.0.1010067","article-title":"Epithelial localization of insulin-like growth factor binding protein 1 in the uterus of the rat during pregnancy, deciduoma-bearing pseudopregnancy and hormone treatment","volume":"101","author":"Sadek","year":"1994","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.jped.2022.11.009_bib0015","doi-asserted-by":"crossref","unstructured":"Graham CH, Lysiak JJ, McCrae KR, Lala PK. Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation. 1992;46:561-72.","DOI":"10.1095\/biolreprod46.4.561"},{"key":"10.1016\/j.jped.2022.11.009_bib0016","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cyto.2012.06.005","article-title":"Fetal concentrations of the growth factors TGF-\u03b1 and TGF-\u03b21 in relation to normal and restricted fetal growth at term","volume":"60","author":"Briana","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.jped.2022.11.009_bib0017","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jri.2008.08.001","article-title":"Platelet aggregation and TGF-beta(1) plasma levels in pregnant women with preeclampsia","volume":"79","author":"Pera\u00e7oli","year":"2008","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jped.2022.11.009_bib0018","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0002-9440(10)63029-5","article-title":"Transforming growth factor-beta expression in human placenta and placental bed in third trimester normal pregnancy, preeclampsia, and fetal growth restriction","volume":"159","author":"Lyall","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jped.2022.11.009_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/318464","article-title":"Changes in maternal serum transforming growth factor beta-1 during pregnancy: a cross-sectional study","volume":"2013","author":"Singh","year":"2013","journal-title":"Biomed Res Int"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572200136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572200136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:23:57Z","timestamp":1758151437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002175572200136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S002175572200136X"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2022.11.009","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal plasma transforming growth factor-\u03b21 (TGF-\u03b21) and newborn size: the Araraquara Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2022.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}