{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:13:57Z","timestamp":1787948037087,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jped.2023.03.003","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T09:17:43Z","timestamp":1681982263000},"page":"478-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cognitive outcome of 458 children over 25 years of neonatal screening for congenital hypothyroidism"],"prefix":"10.1016","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-0694","authenticated-orcid":false,"given":"Julita Maria","family":"Pelaez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-6795","authenticated-orcid":false,"given":"Juliana Cristina Romero","family":"Rojas-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-085X","authenticated-orcid":false,"given":"Mouseline Torquato","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-3998","authenticated-orcid":false,"given":"Marcella Rabassi","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-0398","authenticated-orcid":false,"given":"Gabriela de Carvalho","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-1940","authenticated-orcid":false,"given":"Adriane de Andre","family":"Cardoso-Demartini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-1519","authenticated-orcid":false,"given":"Rosana Marques","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8125-1976","authenticated-orcid":false,"given":"Luiz","family":"de Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3987-3998","authenticated-orcid":false,"given":"Suzana","family":"Nesi-Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2023.03.003_bib0001","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1210\/jc.2006-1538","article-title":"Neonatal screening for congenital hypothyroidism in the Netherlands: cognitive and motor outcome at 10 years of age","volume":"92","author":"Kempers","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.03.003_bib0002","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/adc.2010.190280","article-title":"Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level?","volume":"96","author":"Grosse","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jped.2023.03.003_bib0003","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1210\/jc.2013-1903","article-title":"Neurodevelopmental and body composition outcomes in children with congenital hypothyroidism treated with high-dose initial replacement and close monitoring","volume":"98","author":"Albert","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.03.003_bib0004","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1210\/jc.2017-01937","article-title":"Mean high-dose l-thyroxine treatment is efficient and safe to achieve a normal iq in young adult patients with congenital hypothyroidism","volume":"103","author":"Aleksander","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.03.003_bib0005","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1515\/jpem-2020-0285","article-title":"Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil","volume":"33","author":"Nesi-Franca","year":"2020","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.03.003_bib0006","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1542\/peds.2004-1492","article-title":"Children with congenital hypothyroidism and their siblings: do they really differ?","volume":"115","author":"Rovet","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jped.2023.03.003_bib0007","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1203\/PDR.0b013e31818d2030","article-title":"Children with congenital hypothyroidism: long-term intellectual outcome after early high-dose treatment","volume":"65","author":"Dimitropoulos","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jped.2023.03.003_bib0008","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1651-2227.1999.tb01168.x","article-title":"Long-term neuropsychological sequelae of early-treated congenital hypothyroidism: effects in adolescence","volume":"88","author":"Rovet","year":"1999","journal-title":"Acta Paediatr Suppl"},{"key":"10.1016\/j.jped.2023.03.003_bib0009","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/eje.0.1410105","article-title":"Intellectual outcome at 12 years of age in congenital hypothyroidism","volume":"141","author":"Salerno","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.jped.2023.03.003_bib0010","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1210\/jc.2010-2315","article-title":"Subtle health impairment and socioeducational attainment in young adult patients with congenital hypothyroidism diagnosed by neonatal screening: a longitudinal population-based cohort study","volume":"96","author":"Leger","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.03.003_bib0011","series-title":"Beyond the Flynn Effect","first-page":"274","article-title":"What is intelligence?","author":"Flynn","year":"2007"},{"key":"10.1016\/j.jped.2023.03.003_bib0012","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/1471-2458-8-202","article-title":"Determinants of cognitive function in childhood: a cohort study in a middle income context","volume":"8","author":"Santos","year":"2008","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jped.2023.03.003_bib0013","series-title":"Education at a Glance: OECD Indicators","year":"2019"},{"key":"10.1016\/j.jped.2023.03.003_bib0014","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1365-2265.2004.01974.x","article-title":"Predictors of intellectual outcome in a cohort of Brazilian children with congenital hypothyroidism","volume":"60","author":"Kreisner","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jped.2023.03.003_bib0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/09297049.2021.1876010","article-title":"Socioeconomic aspects are crucial to better intellectual outcome in early-treated adolescents with congenital hypothyroidism","volume":"27","author":"de Andrade","year":"2021","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.jped.2023.03.003_bib0016","first-page":"110","article-title":"Neuropsychological evaluation of congenital hypothyroidism","volume":"64","author":"Pelaez","year":"2005","journal-title":"Horm Res"},{"key":"10.1016\/j.jped.2023.03.003_bib0017","first-page":"99","article-title":"Reliability of the WPPSI-R test in the evaluation of cognitive development in preschool children","volume":"17","author":"Meio","year":"2001","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.jped.2023.03.003_bib0018","series-title":"Adapta\u00e7\u00e3o e Padroniza\u00e7\u00e3o Brasileira De Figueiredo","article-title":"WISC-III. Escala de Intelig\u00eancia Wechsler para Crian\u00e7as","author":"Figueiredo","year":"2002"},{"key":"10.1016\/j.jped.2023.03.003_bib0019","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1076\/chin.7.2.99.3126","article-title":"Using a short form of the WISC-III: sinful or smart?","volume":"7","author":"Donders","year":"2001","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.jped.2023.03.003_bib0020","series-title":"Manual for the Preschool and Primary Scale of Intelligence \u2013 Revised (WPPSI-R)","author":"Wechsler","year":"1989"},{"key":"10.1016\/j.jped.2023.03.003_bib0021","series-title":"Indicadores Da Triagem Neonatal No Brasil","year":"2021"},{"key":"10.1016\/j.jped.2023.03.003_bib0022","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0022-3476(05)81150-3","article-title":"Intellectual development at age 12 years of children with congenital hypothyroidism diagnosed by neonatal screening","volume":"121","author":"Glorieux","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2023.03.003_bib0023","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jpeds.2005.07.024","article-title":"Neurodevelopmental outcomes in congenital hypothyroidism: comparison of initial T4 dose and time to reach target T4 and TSH","volume":"147","author":"Selva","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2023.03.003_bib0024","series-title":"S\u00edntese De Indicadores Sociais: Uma an\u00e1lise Das Condi\u00e7\u00f5es De Vida Da Popula\u00e7\u00e3o Brasileira","year":"2018"},{"key":"10.1016\/j.jped.2023.03.003_bib0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1289\/ehp.02110563","article-title":"Economic gains resulting from the reduction in children's exposure to lead in the United States","volume":"110","author":"Grosse","year":"2002","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jped.2023.03.003_bib0026","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.jped.2023.03.003_bib0027","series-title":"Minist\u00e9rio Da Sa\u00fade, Departamento de A\u00e7\u00f5es Program\u00e1ticas e Estrat\u00e9gicas Coordena\u00e7\u00e3o Geral de Sa\u00fade da Pessoa com Defici\u00eancia [Internet]. Censo Demogr\u00e1fico De 2020 e o Mapeamento Das Pessoas Com Defici\u00eancia No Brasil","year":"2019"},{"key":"10.1016\/j.jped.2023.03.003_bib0028","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(02)07744-9","article-title":"Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study","volume":"359","author":"Berkman","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2023.03.003_bib0029","doi-asserted-by":"crossref","first-page":"144","DOI":"10.7705\/biomedica.6334","article-title":"Neuropsychological and physical development of patients diagnosed with congenital hypothyroidism at the San Ignacio University Hospital between 2001 and 2017","volume":"42","author":"Unigarro","year":"2022","journal-title":"Biomedica"},{"key":"10.1016\/j.jped.2023.03.003_bib0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000522257","article-title":"Cognitive outcomes in congenital hypothyroidism: impact of socioeconomic status - a case-control study","volume":"95","author":"Grob","year":"2022","journal-title":"Horm Res Paediatr"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755723000414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755723000414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:04:57Z","timestamp":1762185897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755723000414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0021755723000414"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2023.03.003","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cognitive outcome of 458 children over 25 years of neonatal screening for congenital hypothyroidism","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2023.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}