{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:49:37Z","timestamp":1793213377075,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303625\/2019-8"],"award-info":[{"award-number":["303625\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jped.2023.06.002","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T08:45:23Z","timestamp":1690879523000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review"],"prefix":"10.1016","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-5727","authenticated-orcid":false,"given":"Pedro Ferro","family":"Berton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-4328","authenticated-orcid":false,"given":"Alessandra","family":"Gambero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2023.06.002_bib0001","series-title":"Obesity and overweight","year":"2021"},{"key":"10.1016\/j.jped.2023.06.002_bib0002","series-title":"Global nutrition targets 2025: policy brief series","year":"2014"},{"key":"10.1016\/j.jped.2023.06.002_bib0003","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/0883073811416867","article-title":"Effect of chronic iron deficiency on neuropsychological domains in infants","volume":"27","author":"Beltran-Navarro","year":"2012","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jped.2023.06.002_bib0004","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jped.2023.06.002_bib0005","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3390\/cells9061456","article-title":"Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases","volume":"9","author":"Kontoghiorghes","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jped.2023.06.002_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13010237","article-title":"Management of anaemia of chronic disease: beyond iron-only supplementation","volume":"13","author":"Pasini","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jped.2023.06.002_bib0007","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/ajcn\/13.6.354","article-title":"Serum iron and iron-binding capacity in adolescents. II. Comparison of obese and nonobese subjects","volume":"13","author":"Seltzer","year":"1963","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jped.2023.06.002_bib0008","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jada.2007.10.034","article-title":"Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption","volume":"108","author":"Menzie","year":"2008","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.jped.2023.06.002_bib0009","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ijo.2009.146","article-title":"Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children","volume":"33","author":"Aeberli","year":"2009","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2023.06.002_bib0010","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.2174\/0929866527666200505214555","article-title":"Adipokines: a rainbow of proteins with metabolic and endocrine functions","volume":"27","author":"Parrettini","year":"2020","journal-title":"Protein Pept Lett"},{"key":"10.1016\/j.jped.2023.06.002_bib0011","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/ejh.13560","article-title":"The hematologic consequences of obesity","volume":"106","author":"Purdy","year":"2021","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jped.2023.06.002_bib0012","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/ph11040127","article-title":"Hepcidin therapeutics","volume":"11","author":"Katsarou","year":"2018","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.jped.2023.06.002_bib0013","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3177\/jnsv.59.454","article-title":"Mice that are fed a high-fat diet display increased hepcidin expression in adipose tissue","volume":"59","author":"Gotardo","year":"2013","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1016\/j.jped.2023.06.002_bib0014","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3324\/haematol.2009.010322","article-title":"Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization","volume":"94","author":"Kroot","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.jped.2023.06.002_bib0015","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ajh.23289","article-title":"Second round robin for plasma hepcidin methods: first steps toward harmonization","volume":"87","author":"Kroot","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jped.2023.06.002_bib0016","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1373\/clinchem.2016.256768","article-title":"Toward worldwide hepcidin assay harmonization: identification of a commutable secondary reference material","volume":"62","author":"van der Vorm","year":"2016","journal-title":"Clin Chem"},{"key":"10.1016\/j.jped.2023.06.002_bib0017","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1515\/cclm-2020-0928","article-title":"Optimizing hepcidin measurement with a proficiency test framework and standardization improvement","volume":"59","author":"Aune","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jped.2023.06.002_bib0018","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0140-6736(62)90110-1","article-title":"Hypoferraemia in obese adolescents","volume":"2","author":"Wenzel","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2023.06.002_bib0019","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ijo.2008.43","article-title":"Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification","volume":"32","author":"Zimmermann","year":"2008","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2023.06.002_bib0020","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1210\/jc.2009-1361","article-title":"Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency","volume":"94","author":"del Giudice","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2023.06.002_bib0021","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ijerph15102156","article-title":"Ferroportin-Hepcidin axis in prepubertal obese children with sufficient daily iron intake","volume":"15","author":"Gajewska","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jped.2023.06.002_bib0022","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1824-7288-37-34","article-title":"Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study","volume":"37","author":"Sanad","year":"2011","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.jped.2023.06.002_bib0023","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000351941","article-title":"Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: relation to body mass index","volume":"80","author":"Hamza","year":"2013","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jped.2023.06.002_bib0024","first-page":"172","article-title":"Study of serum Hepcidin as a potential mediator of the disrupted iron metabolism in obese adolescents","volume":"9","author":"Nazif","year":"2015","journal-title":"Int J Health Sci"},{"key":"10.1016\/j.jped.2023.06.002_bib0025","doi-asserted-by":"crossref","first-page":"175","DOI":"10.23736\/S0026-4946.16.04273-0","article-title":"Iron parameters, pro-hepcidin and soluble transferrin receptor levels in obese children","volume":"72","author":"Dogan","year":"2020","journal-title":"Minerva Pediatr"},{"key":"10.1016\/j.jped.2023.06.002_bib0026","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ijo.2012.145","article-title":"Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention","volume":"37","author":"Baumgartner","year":"2013","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2023.06.002_bib0027","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00431-014-2268-8","article-title":"Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study","volume":"173","author":"Demircioglu","year":"2014","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jped.2023.06.002_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9944035","article-title":"The association between Hepcidin and iron status in children and adolescents with obesity","volume":"2021","author":"Panichsillaphakit","year":"2021","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.jped.2023.06.002_bib0029","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/10245332.2018.1423671","article-title":"Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?","volume":"23","author":"Sal","year":"2018","journal-title":"Hematology"},{"key":"10.1016\/j.jped.2023.06.002_bib0030","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/ejcn.2014.83","article-title":"Tissue iron deficiency and adiposity-related inflammation in disadvantaged preschoolers from NE Brazil","volume":"68","author":"Gibson","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jped.2023.06.002_bib0031","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s40618-017-0823-7","article-title":"soluble transferrin receptor and IL-6 levels in obese children and adolescents with and without type 2 diabetes mellitus\/impaired glucose tolerance and their association with obstructive sleep apnea","volume":"41","author":"Shalitin","year":"2018","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jped.2023.06.002_bib0032","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.nut.2014.02.021","article-title":"Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children: a cross-sectional study in Taiwan","volume":"30","author":"Chang","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.jped.2023.06.002_bib0033","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/pr.2017.139","article-title":"Physical exercise intervention at school improved hepcidin, inflammation, and iron metabolism in overweight and obese children and adolescents","volume":"82","author":"Coimbra","year":"2017","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jped.2023.06.002_bib0034","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/ijo.2010.204","article-title":"Effect of body mass index reduction on serum hepcidin levels and iron status in obese children","volume":"34","author":"Amato","year":"2010","journal-title":"Int J Obes"},{"key":"10.1016\/j.jped.2023.06.002_bib0035","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1017\/S136898002100286X","article-title":"Prevalence of childhood anaemia in Brazil: still a serious health problem: a systematic review and meta-analysis","volume":"24","author":"Nogueira-de-Almeida","year":"2021","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jped.2023.06.002_bib0036","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jped.2020.12.003","article-title":"Prevalence of childhood obesity in Brazil: systematic review and meta-analysis","volume":"97","author":"Ferreira","year":"2021","journal-title":"J Pediatr"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755723000840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755723000840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:25:25Z","timestamp":1758151525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755723000840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0021755723000840"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2023.06.002","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2023.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}