{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:32:42Z","timestamp":1768825962306,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jped.2025.01.008","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:32:21Z","timestamp":1741710741000},"page":"458-465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tuberculosis among young contacts of patients with multidrug-resistant pulmonary tuberculosis in a reference hospital"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0403-2268","authenticated-orcid":false,"given":"Evelyn F.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-2839","authenticated-orcid":false,"given":"Sheila C.","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-026X","authenticated-orcid":false,"given":"Marcela","family":"Bhering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-3146","authenticated-orcid":false,"given":"Lorrayne","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3118-2364","authenticated-orcid":false,"given":"Fabiana","family":"Falc\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-1082","authenticated-orcid":false,"given":"Margareth","family":"Dalcolmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-574X","authenticated-orcid":false,"given":"Giovanni B.","family":"Migliori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-9367","authenticated-orcid":false,"given":"Laura","family":"Saderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-4474","authenticated-orcid":false,"given":"Giovanni","family":"Sotgiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-6007","authenticated-orcid":false,"given":"Afr\u00e2nio","family":"Kritski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-942X","authenticated-orcid":false,"given":"Anna C.C.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2025.01.008_bib0001","series-title":"The End TB Strategy","year":"2015"},{"key":"10.1016\/j.jped.2025.01.008_bib0002","series-title":"Global Tuberculosis Report 2024","year":"2024"},{"key":"10.1016\/j.jped.2025.01.008_bib0003","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade e Ambiente. Departamento de HIV\/Aids, tuberculose, Hepatites virais e infec\u00e7\u00f5es sexualmente transmiss\u00edveis. Boletim Epidemiol\u00f3gico - Tuberculose 2024. N\u00famero especial - Mar\u00e7o de 2024","year":"2024"},{"key":"10.1016\/j.jped.2025.01.008_bib0004","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1473-3099(19)30307-X","article-title":"Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling","volume":"19","author":"Knight","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jped.2025.01.008_bib0005","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0140-6736(20)30166-5","article-title":"The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis","volume":"395","author":"Martinez","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2025.01.008_bib0006","series-title":"Secretaria De Vigil\u00e2ncia em Sa\u00fade, Departamento de Vigil\u00e2ncia das Doen\u00e7as transmiss\u00edveis. Manual de Recomenda\u00e7\u00f5es Para o Controle da Tuberculose no Brasil","year":"2019"},{"key":"10.1016\/j.jped.2025.01.008_bib0007","series-title":"WHO Consolidated Guidelines On tuberculosis. Module 1: prevention \u2013 tuberculosis preventive treatment","year":"2024"},{"key":"10.1016\/j.jped.2025.01.008_bib0008","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1183\/13993003.01245-2015","article-title":"Management of latent mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries","volume":"46","author":"Getahun","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jped.2025.01.008_bib0009","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1056\/NEJMoa2314325","article-title":"Levofloxacin for the prevention of multidrug-resistant tuberculosis in Vietnam","volume":"391","author":"Fox","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2025.01.008_bib0010","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1056\/NEJMoa2314318","article-title":"Levofloxacin preventive treatment in children exposed to MDR tuberculosis","volume":"391","author":"Hesseling","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2025.01.008_bib0011","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1164\/ajrccm.153.1.8542139","article-title":"Transmission of tuberculosis to close contacts of patients with multidrug-resistant tuberculosis","volume":"153","author":"Kritski","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jped.2025.01.008_bib0012","first-page":"321","article-title":"Infection and disease among household contacts of patients with multidrug-resistant tuberculosis","volume":"5","author":"Teixeira","year":"2001","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jped.2025.01.008_bib0013","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Manual de recomenda\u00e7\u00f5es para o controle da tuberculose no Brasil","year":"2011"},{"key":"10.1016\/j.jped.2025.01.008_bib0014","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/cid\/ciz235","article-title":"Feasibility of identifying household contacts of rifampin-and multidrug-resistant tuberculosis cases at high risk of progression to tuberculosis disease","volume":"70","author":"Gupta","year":"2020","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0015","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1183\/09031936.00070812","article-title":"Contact investigation for tuberculosis: a systematic review and meta-analysis","volume":"41","author":"Fox","year":"2013","journal-title":"Eur Respir Soc."},{"key":"10.1016\/j.jped.2025.01.008_bib0016","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1164\/ajrccm.164.12.2103078","article-title":"Transmission of mycobacterium tuberculosis to contacts of HIV-infected tuberculosis patients","volume":"164","author":"Carvalho","year":"2001","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.jped.2025.01.008_bib0017","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1473-3099(08)70071-9","article-title":"Tuberculosis and latent tuberculosis infection in close contacts of people with pulmonary tuberculosis in low-income and middle-income countries: a systematic review and meta-analysis","volume":"8","author":"Morrison","year":"2008","journal-title":"Lancet Infect Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0018","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1183\/09031936.00188313","article-title":"Management of patients with multidrug-resistant\/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement","volume":"44","author":"Lange","year":"2014","journal-title":"Eur Respir J."},{"key":"10.1016\/j.jped.2025.01.008_bib0019","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/cid\/ciad301","article-title":"1-year incidence of tuberculosis infection and disease among household contacts of rifampin- and multidrug-resistant tuberculosis","volume":"77","author":"Krishnan","year":"2023","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1126\/science.118.3063.297","article-title":"Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli","volume":"118","author":"Middlebrook","year":"1953","journal-title":"Science."},{"key":"10.1016\/j.jped.2025.01.008_bib0021","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/bmj.1.4854.128","article-title":"Tubercle bacilli resistant to isoniazid: virulence and response to treatment with isoniazid in guinea-pigs","volume":"1","author":"Mitchison","year":"1954","journal-title":"Br Med J."},{"key":"10.1016\/j.jped.2025.01.008_bib0022","first-page":"125","article-title":"Infection and disease among contacts of tuberculosis cases with drug-resistant and drug-susceptible bacilli","volume":"132","author":"Snider","year":"1985","journal-title":"Am Rev Respir Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0023","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/infdis\/jiv347","article-title":"Fitness costs of drug resistance mutations in multidrug-resistant mycobacterium tuberculosis: a household-based case-control study","volume":"213","author":"Salvatore","year":"2016","journal-title":"J Infect Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-13-392","article-title":"Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis: a cross-sectional study","volume":"13","author":"Seddon","year":"2013","journal-title":"BMC Infect Dis."},{"key":"10.1016\/j.jped.2025.01.008_bib0025","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1164\/rccm.201908-1576OC","article-title":"Isoniazid preventive therapy in contacts of multidrug-resistant tuberculosis","volume":"202","author":"Huang","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.jped.2025.01.008_bib0026","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0140-6736(10)61972-1","article-title":"Tuberculosis burden in households of patients with multidrug-resistant and extensively drug-resistant tuberculosis: a retrospective cohort study","volume":"377","author":"Becerra","year":"2011","journal-title":"Lancet."},{"key":"10.1016\/j.jped.2025.01.008_bib0027","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ebch.1962","article-title":"Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB","volume":"9","author":"Sharma","year":"2014","journal-title":"Evid Based Child Health."},{"key":"10.1016\/j.jped.2025.01.008_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0003306","article-title":"Optimizing the cascade of prevention to protect people from tuberculosis: a potential game changer for reducing global tuberculosis incidence","volume":"4","author":"Matteelli","year":"2024","journal-title":"PLOS Glob Public Health."},{"key":"10.1016\/j.jped.2025.01.008_bib0029","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1378\/chest.09-0394","article-title":"Latent TB infection treatment acceptance and completion in the United States and Canada","volume":"137","author":"Horsburgh","year":"2010","journal-title":"Chest."}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725000282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725000282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:06:03Z","timestamp":1762185963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755725000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0021755725000282"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2025.01.008","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tuberculosis among young contacts of patients with multidrug-resistant pulmonary tuberculosis in a reference hospital","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2025.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}