{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:10:53Z","timestamp":1790619053866,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jped.2025.03.003","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T07:13:21Z","timestamp":1745219601000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-0161","authenticated-orcid":false,"given":"Kallianna Paula Duarte","family":"Gameleira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-7998","authenticated-orcid":false,"given":"Juliana de Vasconcellos","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7200-7828","authenticated-orcid":false,"given":"Vitor Guilherme Brito","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1521-475X","authenticated-orcid":false,"given":"Cl\u00e1udia Vicari","family":"Bolognani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-400X","authenticated-orcid":false,"given":"S\u00e9rgio Eduardo Soares","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-5733","authenticated-orcid":false,"given":"F\u00e1bio Ferreira","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2025.03.003_bib0001","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1056\/NEJMra1909786","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"383","author":"Merke","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2025.03.003_bib0002","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/ijns7030036","article-title":"Thirty-year lessons from the newborn screening for congenital adrenal hyperplasia (CAH) in Japan","volume":"7","author":"Tsuji-Hosokawa","year":"2021","journal-title":"Int J Neonatal Screen"},{"key":"10.1016\/j.jped.2025.03.003_bib0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/endrev\/bnab016","article-title":"Congenital adrenal hyperplasia-current insights in pathophysiology, diagnostics, and management","volume":"43","author":"Claahsen-van der Grinten","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jped.2025.03.003_bib0004","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(22)01330-7","article-title":"Congenital adrenal hyperplasia","volume":"401","author":"Auer","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2025.03.003_bib0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02761890","article-title":"Effect of gender, birth weight, and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia","volume":"62","author":"al-Nuaim","year":"1995","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.jped.2025.03.003_bib0006","first-page":"866","article-title":"Worldwide experience in newborn screening for classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"81","author":"Pang","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.jped.2025.03.003_bib0007","first-page":"188","article-title":"Consensus statement on 21-hydroxylase deficiency from the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society","volume":"58","author":"Clayton","year":"2002","journal-title":"Horm Res"},{"key":"10.1016\/j.jped.2025.03.003_bib0008","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0022-3476(97)70321-4","article-title":"Improved precision of newborn screening for congenital adrenal hyperplasia using weight-adjusted criteria for 17-hydroxyprogesterone levels","volume":"130","author":"Allen","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2025.03.003_bib0009","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1590\/S0004-27302011000800019","article-title":"Weight-adjusted neonatal 17OH-progesterone cutoff levels improve the efficiency of newborn screening for congenital adrenal hyperplasia","volume":"55","author":"Hayashi","year":"2011","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"10.1016\/j.jped.2025.03.003_bib0010","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Triagem neonatal hiperplasia adrenal cong\u00eanita [Internet]. 2015 [Accessed February 16, 2024]. Available from: https:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/triagem_neonatal_hiperplasia_adrenal_congenita.pdf."},{"key":"10.1016\/j.jped.2025.03.003_bib0011","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/cen.13292","article-title":"Neonatal 17-hydroxyprogesterone levels adjusted according to age at sample collection and birthweight improve the efficacy of congenital adrenal hyperplasia newborn screening","volume":"86","author":"Hayashi","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jped.2025.03.003_bib0012","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"103","author":"Speiser","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2025.03.003_bib0013","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/ijns8040057","article-title":"Multiple 17-OHP cutoff co-variates fail to improve 21-hydroxylase deficiency screening accuracy","volume":"8","author":"Matharu","year":"2022","journal-title":"Int J Neonatal Screen"},{"key":"10.1016\/j.jped.2025.03.003_bib0014","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Portaria No 822, de 06 de junho de 2001. Instituir, no \u00e2mbito do Sistema \u00danico de Sa\u00fade, o Programa Nacional de Triagem Neonatal \/PNTN. [Internet]. [Accessed February 16, 2024]. Available from: https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/gm\/2001\/prt0822_06_06_2001.html"},{"key":"10.1016\/j.jped.2025.03.003_bib0015","series-title":"Portaria No 2.829, De 14 De Dezembro De 2012","year":"2001"},{"key":"10.1016\/j.jped.2025.03.003_bib0016","unstructured":"Governo do Distrito Federal. Lei No 4.190, de 06 de agosto de 2008. Assegura a todas as crian\u00e7as nascidas nos hospitais e demais estabelecimentos de aten\u00e7\u00e3o \u00e0 sa\u00fade de gestantes da rede p\u00fablica de sa\u00fade do Distrito Federal o direito ao teste de triagem neonatal, na sua modalidade ampliada. https:\/\/www.dodf.df.gov.br\/index\/visualizararquivo\/?pasta=2008|08_Agosto|DODF\u202f%20155\u202f%2011-08-2008|&arquivo=DODF\u202f%20155\u202f%2011-08-2008\u202f%20SECAO1.pdf"},{"key":"10.1016\/j.jped.2025.03.003_bib0017","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1210\/jc.2004-2136","article-title":"Cutoff levels 17-alpha-hydroxyprogesterone in neonatal screening for congenital adrenal hyperplasia should be based on gestational age rather than birth weight","volume":"90","author":"van der Kamp","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2025.03.003_bib0018","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1210\/jc.2002-021732","article-title":"Screening for congenital adrenal hyperplasia: adjustment of 17-hydroxyprogesterone cut-off values to age and birth weight markedly improves the predictive value","volume":"88","author":"Olgem\u00f6ller","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jped.2025.03.003_bib0019","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/ijns6020037","article-title":"Newborn screening protocols and positive predictive value for congenital adrenal hyperplasia vary across the United States","volume":"6","author":"Speiser","year":"2020","journal-title":"Int J Neonatal Screen"},{"key":"10.1016\/j.jped.2025.03.003_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000526401","article-title":"Ethnic and national differences in congenital adrenal hyperplasia incidence: a systematic review and meta-analysis","volume":"96","author":"Navarro-Zambrana","year":"2023","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jped.2025.03.003_bib0021","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000508075","article-title":"Outcome of newborn screening for congenital adrenal hyperplasia at two time points","volume":"93","author":"Eshragh","year":"2020","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jped.2025.03.003_bib0022","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1001\/jama.2012.5281","article-title":"Cases of congenital adrenal hyperplasia missed by newborn screening in Minnesota","volume":"307","author":"Sarafoglou","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jped.2025.03.003_bib0023","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1515\/jpm-2013-0154","article-title":"Steroid profiling for congenital adrenal hyperplasia by tandem mass spectrometry as a second-tier test reduces follow-up burdens in a tertiary care hospital: a retrospective and prospective evaluation","volume":"42","author":"Seo","year":"2014","journal-title":"J Perinat Med"},{"key":"10.1016\/j.jped.2025.03.003_bib0024","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jpeds.2014.01.038","article-title":"Comparison of newborn screening protocols for congenital adrenal hyperplasia in preterm infants","volume":"164","author":"Sarafoglou","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2025.03.003_bib0025","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/bmj.329.7458.168","article-title":"Diagnostic tests 4: likelihood ratios","volume":"329","author":"Deeks","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jped.2025.03.003_bib0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/picr.PICR_41_18","article-title":"Understanding the properties of diagnostic tests - part 2: likelihood ratios","volume":"9","author":"Ranganathan","year":"2018","journal-title":"Perspect Clin Res"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572500066X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572500066X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:56:41Z","timestamp":1752569801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002175572500066X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S002175572500066X"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2025.03.003","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2025.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}