{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:35:08Z","timestamp":1788546908586,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jped.2025.101455","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T22:12:22Z","timestamp":1761257542000},"page":"101455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: age-stratified insights from the FAERS database"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-353X","authenticated-orcid":false,"given":"Dilara","family":"Bayram-Ozgur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9741-3976","authenticated-orcid":false,"given":"Onur","family":"Colak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-0512","authenticated-orcid":false,"given":"Onur","family":"Gultekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-8631","authenticated-orcid":false,"given":"Narin","family":"Akici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-1756","authenticated-orcid":false,"given":"Zehra Esra","family":"Onal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8593-0818","authenticated-orcid":false,"given":"Ahmet","family":"Akici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2025.101455_bib0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jdin.2023.06.014","article-title":"Epidemiology of Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States and factors predictive of outcome","volume":"13","author":"Wasuwanich","year":"2023","journal-title":"JAAD Int"},{"issue":"3","key":"10.1016\/j.jped.2025.101455_bib0002","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s12016-021-08859-0","article-title":"Current perspectives on severe drug eruption","volume":"61","author":"Zhang","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jped.2025.101455_bib0003","article-title":"The epidemiology of Stevens-Johnson syndrome and toxic epidermal necrolysis in China","author":"Yang","year":"2018","journal-title":"J Immunol Res"},{"issue":"4","key":"10.1016\/j.jped.2025.101455_bib0004","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/jamadermatol.2022.6378","article-title":"Worldwide prevalence of antibiotic-associated Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis","volume":"159","author":"Lee","year":"2023","journal-title":"JAMA Dermatol"},{"issue":"12","key":"10.1016\/j.jped.2025.101455_bib0005","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/epi.14591","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: an analysis of the US food and drug administration adverse event reporting system","volume":"59","author":"Borrelli","year":"2018","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.jped.2025.101455_bib0006","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1111\/jcpt.13740","article-title":"Allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: signal detection and preventability from Vietnam national pharmacovigilance database","volume":"47","author":"Huong","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.jped.2025.101455_bib0007","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2147\/CCID.S422928","article-title":"Causes of drug-induced severe cutaneous adverse reaction epidermal necrolysis (EN): an analysis using FDA adverse event reporting system (FAERS) database","volume":"16","author":"Fei","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0008","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/pde.13383","article-title":"Incidence, outcomes, and resource use in children hospitalized with Stevens\u2013Johnson syndrome and toxic epidermal necrolysis","volume":"35","author":"Antoon","year":"2018","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jped.2025.101455_bib0009","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20419.1","article-title":"Pediatric SJS-TEN: where are we now?","volume":"9","author":"Ramien","year":"2020","journal-title":"F1000Res"},{"issue":"10","key":"10.1016\/j.jped.2025.101455_bib0010","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1159\/000531366","article-title":"A comprehensive assessment of long-term complications in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"184","author":"Cekic","year":"2023","journal-title":"Int Arch Allergy Immunol"},{"issue":"5","key":"10.1016\/j.jped.2025.101455_bib0011","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/bjd\/ljad234","article-title":"Lifetime risk, life expectancy, loss-of-life expectancy and lifetime healthcare expenditure for Stevens-Johnson syndrome\/toxic epidermal necrolysis in Taiwan: follow-up of a nationwide cohort from 2008 to 2019","volume":"189","author":"Chiu","year":"2023","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1016\/j.jped.2025.101455_bib0012","first-page":"675","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: analysis of the Russian database of spontaneous reports","volume":"17","author":"Zyryanov","year":"2024","journal-title":"Pharm (Basel)"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0013","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1542\/peds.2008-1923","article-title":"Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis","volume":"123","author":"Levi","year":"2009","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.jped.2025.101455_bib0014","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12519-016-0057-3","article-title":"Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children: 20 years study in a tertiary care hospital","volume":"13","author":"Techasatian","year":"2017","journal-title":"World J Pediatr"},{"issue":"9","key":"10.1016\/j.jped.2025.101455_bib0015","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/jdv.20054","article-title":"Drugs associated with epidermal necrolysis in children: a world health organization pharmacovigilance database analysis","volume":"38","author":"Bataille","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0016","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/bcp.13445","volume":"84","author":"Lebrun-Vignes","year":"2018","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.jped.2025.101455_bib0017","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.jid.5701033","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study","volume":"128","author":"Mockenhaupt","year":"2008","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jped.2025.101455_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2017-000039","article-title":"Retrospective review of paediatric case reports of Stevens-Johnson syndrome and toxic epidermal necrolysis with lamotrigine from an international pharmacovigilance database","volume":"1","author":"Egunsola","year":"2017","journal-title":"BMJ Paediatr Open"},{"issue":"Suppl 4","key":"10.1016\/j.jped.2025.101455_bib0019","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1017\/S0317167100034910","article-title":"Rash in adult and pediatric patients treated with lamotrigine","volume":"25","author":"Messenheimer","year":"1998","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0020","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1542\/peds.2006-0148","article-title":"Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic clonic seizures","volume":"118","author":"Trevathan","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jped.2025.101455_bib0021","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pediatrneurol.2017.06.011","article-title":"Initial treatment for nonsyndromic early life epilepsy: an unexpected consensus","volume":"75","author":"Shellhaas","year":"2017","journal-title":"Pediatr Neurol"},{"issue":"10","key":"10.1016\/j.jped.2025.101455_bib0022","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/cid\/ciu126","article-title":"Severe cutaneous adverse reactions related to systemic antibiotics","volume":"58","author":"Lin","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jped.2025.101455_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1415830","article-title":"Antibiotic-induced severe cutaneous adverse reactions: a single-center retrospective study over ten years","volume":"15","author":"Lu","year":"2024","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jped.2025.101455_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2019.11.003","article-title":"CD39\u207a regulatory T cells modulate the immune response to carbamazepine in HLA-B*15:02 carriers","volume":"225","author":"Shen","year":"2020","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s13181-015-0472-1","article-title":"Data mining FAERS to analyze molecular targets of drugs highly associated with Stevens-Johnson syndrome","volume":"11","author":"Burkhart","year":"2015","journal-title":"J Med Toxicol"},{"issue":"5","key":"10.1016\/j.jped.2025.101455_bib0026","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/INF.0000000000001571","article-title":"Fever in Stevens-Johnson syndrome and toxic epidermal necrolysis in pediatric cases: laboratory work-up and antibiotic therapy","volume":"36","author":"Paulmann","year":"2017","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"10.1016\/j.jped.2025.101455_bib0027","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2017.11.023","article-title":"SJS\/TEN 2017: building multidisciplinary networks to drive science and translation","volume":"6","author":"White","year":"2018","journal-title":"J Allergy Clin Immunol Pr"},{"issue":"2","key":"10.1016\/j.jped.2025.101455_bib0028","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/bjd.14799","article-title":"Major psychological complications and decreased health-related quality of life among survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"175","author":"Dodiuk-Gad","year":"2016","journal-title":"Br J Dermatol"},{"issue":"6","key":"10.1016\/j.jped.2025.101455_bib0029","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamadermatol.2021.1136","article-title":"Long-term physical and psychological outcomes of Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"157","author":"Hoffman","year":"2021","journal-title":"JAMA Dermatol"},{"issue":"10","key":"10.1016\/j.jped.2025.101455_bib0030","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jamadermatol.2021.3154","article-title":"Assessment of treatment approaches and outcomes in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"157","author":"Kridin","year":"2021","journal-title":"JAMA Dermatol"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:20:31Z","timestamp":1770412831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755725001445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0021755725001445"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2025.101455","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: age-stratified insights from the FAERS database","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2025.101455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}],"article-number":"101455"}}