{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:43:37Z","timestamp":1787586217363,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jped.2025.101461","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:47:41Z","timestamp":1761871661000},"page":"101461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac manifestations in children and adolescents diagnosed with pediatric multisystem inflammatory syndrome related to COVID-19"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6494-6748","authenticated-orcid":false,"given":"Thiago T.","family":"Panizzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5774-365X","authenticated-orcid":false,"given":"Katharine A.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5250-7552","authenticated-orcid":false,"given":"Gabriela B.","family":"Stutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6965-5703","authenticated-orcid":false,"given":"Fernanda M.C.F.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-3824","authenticated-orcid":false,"given":"Marta C.F.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-8158","authenticated-orcid":false,"given":"Rozana G.","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-865X","authenticated-orcid":false,"given":"Luciane A.","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-9664","authenticated-orcid":false,"given":"Flavio R.","family":"Sztajnbok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-3552","authenticated-orcid":false,"given":"Adriana R.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-4877","authenticated-orcid":false,"given":"Nathalie J.M.","family":"Bravo-Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10237","key":"10.1016\/j.jped.2025.101461_bib0001","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","author":"Riphagen","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jped.2025.101461_bib0002","first-page":"1","article-title":"S\u00edndrome inflamat\u00f3ria multissist\u00eamica pedi\u00e1trica (SIM-P) temporalmente associada a COVID-19: atualiza\u00e7\u00e3o","volume":"11","author":"Campos","year":"2021","journal-title":"Resid Pediatr"},{"issue":"4","key":"10.1016\/j.jped.2025.101461_bib0003","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1002\/art.42062","article-title":"American College of Rheumatology Clinical Guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: version 3","volume":"74","author":"Henderson","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.jped.2025.101461_bib0004","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00431-020-03766-6","article-title":"Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach","volume":"180","author":"Sperotto","year":"2021","journal-title":"Eur J Pediatr"},{"issue":"21","key":"10.1016\/j.jped.2025.101461_bib0005","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.12998\/wjcc.v8.i21.5250","article-title":"Cardiovascular impact of COVID-19 with a focus on children: a systematic review","volume":"8","author":"Rodriguez-Gonzalez","year":"2020","journal-title":"World J Clin Cases"},{"issue":"1","key":"10.1016\/j.jped.2025.101461_bib0006","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.120.050065","article-title":"Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 Infection in Europe","volume":"143","author":"Valverde","year":"2021","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jped.2025.101461_bib0007","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/0009922820961771","article-title":"Cardiac findings in pediatric patients with multisystem inflammatory syndrome in children associated with COVID-19","volume":"60","author":"Minocha","year":"2021","journal-title":"Clin Pediatr (Phila)"},{"issue":"6","key":"10.1016\/j.jped.2025.101461_bib0008","first-page":"917","article-title":"Advanced echocardiographic analysis in medium-term follow-up of children with previous multisystem inflammatory syndrome","volume":"9","author":"Garbin","year":"2022","journal-title":"Child (Basel)"},{"issue":"8","key":"10.1016\/j.jped.2025.101461_bib0009","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.echo.2021.04.018","article-title":"Echocardiographic Indicators Associated with Adverse Clinical Course and Cardiac Sequelae in Multisystem Inflammatory Syndrome in Children with Coronavirus Disease 2019","volume":"34","author":"Sanil","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"issue":"10","key":"10.1016\/j.jped.2025.101461_bib0010","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s12098-022-04385-9","article-title":"Multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 and 1-year follow-up","volume":"90","author":"Kapoor","year":"2023","journal-title":"Indian J Pediatr"},{"issue":"11","key":"10.1016\/j.jped.2025.101461_bib0011","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s11886-021-01602-3","article-title":"Cardiac manifestations of multisystem inflammatory syndrome in children (MIS-C) following COVID-19","volume":"23","author":"Wu","year":"2021","journal-title":"Curr Cardiol Rep"},{"issue":"5","key":"10.1016\/j.jped.2025.101461_bib0012","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1007\/s00246-023-03375-8","article-title":"Longitudinal cardiac evaluation of children with multisystem inflammatory syndrome (MIS-C) following COVID-19 by conventional and speckle-tracking echocardiography","volume":"45","author":"Anagnostopoulou","year":"2024","journal-title":"Pediatr Cardiol"},{"issue":"2","key":"10.1016\/j.jped.2025.101461_bib0013","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00246-024-03432-w","article-title":"Cardiac function in pediatric patients with mis-c using speckle tracking and conventional echocardiography: a longitudinal, single-center study","volume":"46","author":"Sabri","year":"2025","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jped.2025.101461_bib0014","unstructured":"World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19. (2020). [Cited 2025 Jul 17]. Available from:https:\/\/www.who.int\/publications\/i\/item\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19."},{"issue":"5","key":"10.1016\/j.jped.2025.101461_bib0015","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5152\/TurkArchPediatr.2023.23070","article-title":"Echocardiographic findings in children with multisystem inflammatory syndrome from initial presentation to the first years after discharge","volume":"58","author":"Bulut","year":"2023","journal-title":"Turk Arch Pediatr"},{"key":"10.1016\/j.jped.2025.101461_bib0016","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria Extraordin\u00e1ria de Enfrentamento \u00e0 COVID-19. Secovid. Plano Nacional de Operacionaliza\u00e7\u00e3o da Vacina\u00e7\u00e3o Contra a COVID-19. [Cited 2025 Jul 03]. Available from:https:\/\/www.gov.br\/saude\/pt-br\/assuntos\/saude-de-a-a-z\/c\/covid-19\/publicacoes-tecnicas\/guias-e-planos\/plano-nacional-de-operacionalizacao-da-vacinacao-contra-covid-19.pdf\/view?utm_source=chatgpt.com."},{"key":"10.1016\/j.jped.2025.101461_bib0017","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria Extraordin\u00e1ria de Enfrentamento \u00e0 COVID-19. Gabinete. Nota T\u00e9cnica N\u00b0 2\/2022-SECOVID\/GAB\/SECOVID\/MS. Cuida-se de vacina\u00e7\u00e3o n\u00e3o obrigat\u00f3ria de crian\u00e7as de 05 a 11 anos contra Covid-19 durante a Pandemia da Covid-19. [Cited 2025 Jul 03]. Available from: https:\/\/www.gov.br\/saude\/pt-br\/centrais-de-conteudo\/publicacoes\/notas-tecnicas\/2022\/nota-tecnica-02-2022-vacinacao-de-5-11-anos.pdf\/view."},{"key":"10.1016\/j.jped.2025.101461_bib0018","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de vigil\u00e2ncia em sa\u00fade e ambiente. Departamento do programa nacional de imuniza\u00e7\u00f5es. Nota t\u00e9cnica N\u00b0 118\/2023-CGICI\/DPNI\/SVSA\/MS. Trata-se da incorpora\u00e7\u00e3o das vacinas COVID-19 no Calend\u00e1rio Nacional de Vacina\u00e7\u00e3o Infantil, para crian\u00e7as de 6 meses a menores de 5 anos de idade, a partir de 01 de janeiro de 2024 [Cited 2025 Jul 03]. Available from:https:\/\/www.gov.br\/saude\/pt-br\/centrais-de-conteudo\/publicacoes\/notas-tecnicas\/2023\/nota-tecnica-no-118-2023-cgici-dpni-svsa-ms."},{"issue":"11","key":"10.1016\/j.jped.2025.101461_bib0019","first-page":"2027","article-title":"Clinical syndromes related to SARS-CoV-2 infection and vaccination in pediatric age: a narrative review","volume":"59","author":"Mastrolia","year":"2023","journal-title":"Med (Kaunas)"},{"key":"10.1016\/j.jped.2025.101461_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.626182","article-title":"Multisystem inflammatory syndrome in children (MIS-C), a post-viral myocarditis and systemic vasculitis-a critical review of its pathogenesis and treatment","volume":"8","author":"McMurray","year":"2020","journal-title":"Front Pediatr"},{"issue":"5","key":"10.1016\/j.jped.2025.101461_bib0021","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S2352-4642(21)00050-X","article-title":"Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA: a retrospective surveillance study","volume":"5","author":"Abrams","year":"2021","journal-title":"Lancet Child Adolesc Health"},{"issue":"7","key":"10.1016\/j.jped.2025.101461_bib0022","first-page":"66327","article-title":"Cardiovascular diseases in children with multisystem inflammatory syndrome from covid-19 infection: an integrative review","volume":"7","author":"Alonso","year":"2021","journal-title":"Braz J Dev"},{"issue":"10","key":"10.1016\/j.jped.2025.101461_bib0023","doi-asserted-by":"crossref","first-page":"533","DOI":"10.47102\/annals-acadmedsg.V52N10p533","article-title":"Cardiovascular effects of COVID-19 in children","volume":"52","author":"Broberg","year":"2023","journal-title":"Ann Acad Med Singap"},{"issue":"5","key":"10.1016\/j.jped.2025.101461_bib0024","article-title":"Clinical course and outcome of cardiovascular manifestations in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection in Georgia","volume":"15","author":"Phirtskhalava","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.jped.2025.101461_bib0025","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/apc.apc_121_22","article-title":"Cardiac findings in multisystem inflammatory syndrome in children: short term follow up in a large Indian series","volume":"16","author":"Shah","year":"2023","journal-title":"Ann Pediatr Cardiol"},{"key":"10.1016\/j.jped.2025.101461_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1253608","article-title":"Evaluation of late cardiac effects after multisystem inflammatory syndrome in children","volume":"11","author":"De Wolf","year":"2023","journal-title":"Front Pediatr"},{"issue":"3","key":"10.1016\/j.jped.2025.101461_bib0027","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005521","article-title":"Global longitudinal strain by echocardiography predicts long-term risk of cardiovascular morbidity and mortality in a low-risk general population: the Copenhagen city heart study","volume":"10","author":"Biering-S\u00f8rensen","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.jped.2025.101461_bib0028","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12750","article-title":"Segmental cardiac strain assessment by two-dimensional speckle-tracking echocardiography in surviving MIS-c patients: correlations with myocardial flow reserve (MFR) by 13 N-ammonia PET-CT","volume":"29","author":"Leal","year":"2022","journal-title":"Microcirculation"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:20:36Z","timestamp":1770412836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755725001500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0021755725001500"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2025.101461","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac manifestations in children and adolescents diagnosed with pediatric multisystem inflammatory syndrome related to COVID-19","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2025.101461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}],"article-number":"101461"}}