{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:53:14Z","timestamp":1782060794528,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jped.2025.101473","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:36:53Z","timestamp":1763660213000},"page":"101473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of continuous renal replacement therapy in critically ill children with cancer and multiple organ dysfunction syndrome"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8297-7213","authenticated-orcid":false,"given":"Fernanda P.L.F.","family":"Veiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-6801","authenticated-orcid":false,"given":"Orlei R.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8391-0449","authenticated-orcid":false,"given":"Alessandra S.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8419-9226","authenticated-orcid":false,"given":"Marcela S.","family":"Bicalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-0613","authenticated-orcid":false,"given":"Maria C.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-0495","authenticated-orcid":false,"given":"Dafne C.B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3_suppl Suppl 1","key":"10.1016\/j.jped.2025.101473_bib0001","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/PCC.0000000000001047","article-title":"Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome","volume":"18","author":"Watson","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"2","key":"10.1016\/j.jped.2025.101473_bib0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jped.2023.01.001","article-title":"Management of septic shock in children with cancer-common challenges and research priorities","volume":"99","author":"Agulnik","year":"2023","journal-title":"J Pediatr (Rio J)"},{"issue":"5","key":"10.1016\/j.jped.2025.101473_bib0003","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.semnephrol.2008.05.005","article-title":"Renal supportive therapy for pediatric acute kidney injury in the setting of multiorgan dysfunction syndrome\/sepsis","volume":"28","author":"Brophy","year":"2008","journal-title":"Semin Nephrol"},{"issue":"7","key":"10.1016\/j.jped.2025.101473_bib0004","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/medicina55070350","article-title":"Evaluation of continuous renal replacement therapy and therapeutic plasma exchange, in severe sepsis or septic shock in critically ill children","volume":"55","author":"Ayg\u00fcn","year":"2019","journal-title":"Medicina (Kaunas)."},{"issue":"1 Suppl 1","key":"10.1016\/j.jped.2025.101473_bib0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1542\/peds.2021-052888B","article-title":"Pediatric organ dysfunction information update mandate (PODIUM) contemporary organ dysfunction criteria: executive summary","volume":"149","author":"Bembea","year":"2022","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.jped.2025.101473_bib0006","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/PCC.0000000000001191","article-title":"Validation of the vasoactive-inotropic score in pediatric sepsis","volume":"18","author":"McIntosh","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"10.1016\/j.jped.2025.101473_bib0007","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1542\/peds.107.6.1309","article-title":"Outcome in children receiving continuous veno-venous hemofiltration","volume":"107","author":"Goldstein","year":"2001","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.jped.2025.101473_bib0008","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.jped.2025.101473_bib0009","article-title":"The simple difference formula: an approach to teaching nonparametric correlation","volume":"3","author":"Kerby","year":"2014","journal-title":"Comprehensive Psychology"},{"issue":"9","key":"10.1016\/j.jped.2025.101473_bib0010","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/pon.4777","article-title":"Using generalized estimating equations and extensions in randomized trials with missing longitudinal patient reported outcome data","volume":"27","author":"Bell","year":"2018","journal-title":"Psychooncology"},{"issue":"5","key":"10.1016\/j.jped.2025.101473_bib0011","doi-asserted-by":"crossref","first-page":"615","DOI":"10.17219\/acem\/81051","article-title":"Factors affecting mortality in children requiring continuous renal replacement therapy in pediatric intensive care unit","volume":"28","author":"Miklaszewska","year":"2019","journal-title":"Adv Clin Exp Med"},{"issue":"4","key":"10.1016\/j.jped.2025.101473_bib0012","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/PCC.0000000000001806","article-title":"Mortality of critically ill children requiring continuous renal replacement therapy: effect of fluid overload, underlying disease, and timing of initiation","volume":"20","author":"Cortina","year":"2019","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"10.1016\/j.jped.2025.101473_bib0013","first-page":"e1084","article-title":"Patterns of multiple organ dysfunction and renal recovery in critically ill children and young adults receiving continuous renal replacement therapy","volume":"6","author":"Thadani","year":"2024","journal-title":"Crit Care Explor"},{"issue":"6","key":"10.1016\/j.jped.2025.101473_bib0014","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jped.2024.04.004","article-title":"The death risk of pediatric patients with cancer-related sepsis requiring continuous renal replacement therapy: a retrospective cohort study","volume":"100","author":"Ma","year":"2024","journal-title":"J Pediatr (Rio J)"},{"issue":"11","key":"10.1016\/j.jped.2025.101473_bib0015","doi-asserted-by":"crossref","first-page":"e893","DOI":"10.1097\/CCM.0000000000003973","article-title":"Epidemiology and outcome of critically ill pediatric cancer and hematopoietic stem cell transplant patients requiring continuous renal replacement therapy: a retrospective nationwide cohort study","volume":"47","author":"Raymakers-Janssen","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jped.2025.101473_bib0016","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbadis.2009.03.004","article-title":"Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria","volume":"1792","author":"Kozlov","year":"2009","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jped.2025.101473_bib0017","article-title":"Pathogenesis of multiple organ failure: the impact of systemic damage to plasma membranes","volume":"9","author":"Kozlov","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jped.2025.101473_bib0018","first-page":"752","article-title":"AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis","volume":"118","author":"Vad\u00e1sz","year":"2008","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jped.2025.101473_bib0019","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ki.2011.243","article-title":"Critical care nephrology: management of acid-base disorders with CRRT","volume":"82","author":"Cerd\u00e1","year":"2012","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.jped.2025.101473_bib0020","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.2215\/CJN.01280214","article-title":"Regional citrate anticoagulation for RRTs in critically ill patients with AKI","volume":"9","author":"Morabito","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.jped.2025.101473_bib0021","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00134-002-1585-y","article-title":"Mortality and the nature of metabolic acidosis in children with shock","volume":"29","author":"Hatherill","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jped.2025.101473_bib0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00000658-199607000-00015","article-title":"Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability","volume":"224","author":"Gore","year":"1996","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.jped.2025.101473_bib0023","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.ackd.2016.02.005","article-title":"Continuous renal replacement therapy for the management of acid-base and electrolyte imbalances in acute kidney injury","volume":"23","author":"Yessayan","year":"2016","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.jped.2025.101473_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.795158","article-title":"Mortality of hemato-oncologic patients admitted to a pediatric intensive care unit: a single-center experience","volume":"10","author":"Pechlaner","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jped.2025.101473_bib0025","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13054-025-05343-5","article-title":"Ventilation-induced acute kidney injury in acute respiratory failure: do PEEP levels matter?","volume":"29","author":"Benites","year":"2025","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.jped.2025.101473_bib0026","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.3390\/jcm14062067","article-title":"Acute respiratory distress syndrome and fluid management: finding the perfect balance","volume":"14","author":"Sbaraini Zernini","year":"2025","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.jped.2025.101473_bib0027","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcrc.2011.05.005","article-title":"Lung-protective mechanical ventilation does not protect against acute kidney injury in patients without lung injury at onset of mechanical ventilation","volume":"27","author":"Cortjens","year":"2012","journal-title":"J Crit Care"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755725001627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:27:07Z","timestamp":1769783227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755725001627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0021755725001627"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2025.101473","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of continuous renal replacement therapy in critically ill children with cancer and multiple organ dysfunction syndrome","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2025.101473","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}],"article-number":"101473"}}