{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:38:44Z","timestamp":1787564324569,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020225","name":"Universidade de Fortaleza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jped.2026.101530","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:12:40Z","timestamp":1775520760000},"page":"101530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serologic response to VDRL in infants with congenital syphilis: ceftriaxone vs. penicillin"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3830-7767","authenticated-orcid":false,"given":"Ana Nery Melo","family":"Cavalcante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-5783","authenticated-orcid":false,"given":"Maria Alix Leite","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7524-3797","authenticated-orcid":false,"given":"Beatriz Sobreira Camilo","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0855-4943","authenticated-orcid":false,"given":"Marina Arrais","family":"Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-543X","authenticated-orcid":false,"given":"Rosa L\u00edvia Freitas","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jped.2026.101530_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211720","article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes: estimates for 2016 and progress since 2012","volume":"14","author":"Korenromp","year":"2019","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jped.2026.101530_bib0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102203","article-title":"Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic review and meta-analysis","volume":"9","author":"Qin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jped.2026.101530_bib0003","series-title":"Clinical protocol and therapeutic guidelines for preventing vertical transmission of HIV, syphilis and viral hepatitis","year":"2022"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0004","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijantimicag.2015.10.020","article-title":"Meta-analysis of ceftriaxone compared with penicillin for the treatment of syphilis","volume":"47","author":"Liang","year":"2016","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"10.1016\/j.jped.2026.101530_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159483","article-title":"Estimating benzathine penicillin need for the treatment of pregnant women diagnosed with syphilis during antenatal care in high-morbidity countries","volume":"11","author":"Taylor","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jped.2026.101530_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002473","article-title":"Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: an evaluation from multi-country surveys and stakeholder interviews","volume":"14","author":"Nurse-Findlay","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.jped.2026.101530_bib0007","series-title":"WHO guidelines for the treatment of treponema pallidum (syphilis): recommendations for treatment of syphilis","year":"2016"},{"issue":"5","key":"10.1016\/j.jped.2026.101530_bib0008","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3201\/eid2305.161936","article-title":"Amoxicillin and ceftriaxone as treatment alternatives to penicillin for maternal syphilis","volume":"23","author":"Katanami","year":"2017","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"10.1016\/j.jped.2026.101530_bib0009","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/01.olq.0000170443.70739.cd","article-title":"A study evaluating ceftriaxone as a treatment agent for primary and secondary syphilis in pregnancy","volume":"32","author":"Zhou","year":"2005","journal-title":"Sex Transm Dis"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009010","article-title":"Congenital syphilis in Argentina: experience in a pediatric hospital","volume":"15","author":"Garcia","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"10.1016\/j.jped.2026.101530_bib0011","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/OLQ.0000000000002057","article-title":"Congenital syphilis: comprehensive narrative review of alternative antibiotic treatment for use in neonates","volume":"51","author":"Villarreal","year":"2024","journal-title":"Sex Transm Dis"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0012","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s40942-025-00689-y","article-title":"Comparative evaluation of long-term ophthalmic sequelae following first versus second-line antibiotic treatment for congenital syphilis","volume":"11","author":"Pereira","year":"2025","journal-title":"Int J Retina Vitr"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0013","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12887-021-02619-x","article-title":"Treatment administered to newborns with congenital syphilis during a penicillin shortage in 2015, Fortaleza, Brazil","volume":"21","author":"Rocha","year":"2021","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jped.2026.101530_bib0014","unstructured":"Ministry of Health (Bazil). Joint informative note no. 109\/2015: prioritization of benzathine penicillin for syphilis in pregnant women and crystalline penicillin for congenital syphilis and treatment alternatives. Bras\u00edlia: Ministry of Health; 2015."},{"key":"10.1016\/j.jped.2026.101530_bib0015","unstructured":"Ministry of Health (Brazil). Joint informative note no. 68\/2016: guidance on treatment of congenital syphilis and neurosyphilis in newborns in the absence of crystalline or potassium penicillin g. Bras\u00edlia: Ministry of Health; 2016. [Cited 2024 Apr 24]. Available from:https:\/\/antigo.aids.gov.br\/pt-br\/legislacao\/nota-informativa-conjunta-no-682016ddahvsvsms-e-dapessasms"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0016","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40272-016-0197-x","article-title":"Ceftriaxone-associated biliary and cardiopulmonary adverse events in neonates: a systematic review of the literature","volume":"19","author":"Donnelly","year":"2017","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.jped.2026.101530_bib0017","unstructured":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (BR). Electronic drug leaflet: ceftriaxone. [Cited 2024 Apr 25]. Available from: https:\/\/consultas.anvisa.gov.br\/#\/bulario\/detalhe\/1666659?numeroRegistro=100410189"},{"key":"10.1016\/j.jped.2026.101530_bib0018","series-title":"Clinical protocol and therapeutic guidelines for comprehensive care for people with sexually transmitted infections","year":"2015"},{"key":"10.1016\/j.jped.2026.101530_bib0019","series-title":"Guidelines for controlling congenital syphilis: pocket manual","year":"2006"},{"issue":"10","key":"10.1016\/j.jped.2026.101530_bib0020","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/cid\/cix611","article-title":"A multicenter study evaluating ceftriaxone and benzathine penicillin G as treatment agents for early syphilis in Jiangsu, China","volume":"65","author":"Cao","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.jped.2026.101530_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180001","article-title":"Comparison of efficacy of treatments for early syphilis: a systematic review and network meta-analysis of randomized controlled trials and observational studies","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jped.2026.101530_bib0022","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/OLQ.0b013e31827bd688","article-title":"Clinical features and follow-up of congenital syphilis","volume":"40","author":"Lago","year":"2013","journal-title":"Sex Transm Dis"},{"issue":"3","key":"10.1016\/j.jped.2026.101530_bib0023","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jped.2022.11.011","article-title":"Follow-up of infants with congenital syphilis during the penicillin shortage period","volume":"99","author":"Rocha","year":"2023","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.jped.2026.101530_bib0024","doi-asserted-by":"crossref","first-page":"95","DOI":"10.11606\/s1518-8787.2019053001284","article-title":"Factors associated with inadequate follow-up of children with congenital syphilis","volume":"53","author":"Cavalcante","year":"2019","journal-title":"Rev Saude Publica"},{"issue":"4","key":"10.1016\/j.jped.2026.101530_bib0025","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1590\/1980-5497201600040004","article-title":"Adherence to the follow-up of the newborn exposed to syphilis and factors associated with loss to follow-up","volume":"19","author":"Feliz","year":"2016","journal-title":"Rev Bras Epidemiol"},{"issue":"3","key":"10.1016\/j.jped.2026.101530_bib0026","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.semperi.2018.02.005","article-title":"Congenital syphilis","volume":"42","author":"Cooper","year":"2018","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.jped.2026.101530_bib0027","doi-asserted-by":"crossref","DOI":"10.1590\/1980-265x-tce-2022-0318en","article-title":"Childcare and follow-up of children exposed to syphilis or diagnosed with congenital syphilis","volume":"32","author":"Oliveira","year":"2023","journal-title":"Texto Contexto Enferm"},{"issue":"2","key":"10.1016\/j.jped.2026.101530_bib0028","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1590\/1413-81232018232.01772016","article-title":"Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, Cear\u00e1, Brazil","volume":"23","author":"Cardoso","year":"2018","journal-title":"Cien Saude Colet"},{"issue":"1","key":"10.1016\/j.jped.2026.101530_bib0029","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/1980-5497201600010006","article-title":"Maternal and congenital syphilis, underreported and difficult to control","volume":"19","author":"Lafet\u00e1","year":"2016","journal-title":"Rev Bras Epidemiol"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572600032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002175572600032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:23:54Z","timestamp":1779207834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002175572600032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S002175572600032X"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2026.101530","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serologic response to VDRL in infants with congenital syphilis: ceftriaxone vs. penicillin","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2026.101530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}],"article-number":"101530"}}