{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:54:10Z","timestamp":1791017650299,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["142205\/2020-6"],"award-info":[{"award-number":["142205\/2020-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jped.2026.101625","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:46:16Z","timestamp":1790109976000},"page":"101625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-effectiveness of oral food challenge in managing cow's milk allergy under the Brazilian Public Health perspective"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5201-0444","authenticated-orcid":false,"given":"Vanessa C.C.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-3715","authenticated-orcid":false,"given":"Marcelo C.M.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-5549","authenticated-orcid":false,"given":"Mauro B.","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jped.2026.101625_bib0001","first-page":"5","article-title":"Update on food allergy 2025: joint position statement of the Brazilian Association of Allergy and Immunology and the Brazilian Society of Pediatrics","volume":"9","author":"Oliveira","year":"2025","journal-title":"Arq Asma Alerg Imunol"},{"issue":"2","key":"10.1016\/j.jped.2026.101625_bib0002","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/MPG.0000000000003897","article-title":"An ESPGHAN position paper on the diagnosis, management, and prevention of cow's milk allergy","volume":"78","author":"Vandenplas","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.jped.2026.101625_bib0003","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.aller.2016.04.009","article-title":"Prevalence of food allergy in infants and pre-schoolers in Brazil","volume":"44","author":"Gon\u00e7alves","year":"2016","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jped.2026.101625_bib0004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2431-10-25","article-title":"A survey on clinical presentation and nutritional status of infants with suspected cow' milk allergy","volume":"10","author":"Vieira","year":"2010","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.jped.2026.101625_bib0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jpn3.12203","article-title":"Out-of-pocket expenses and parent reported quality of life in children with cow's milk protein allergy in Bogot\u00e1, Colombia","volume":"79","author":"Fakih-Botero","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7","key":"10.1016\/j.jped.2026.101625_bib0006","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/cea.14180","article-title":"Trends in use of specialized formula for managing cow's milk allergy in young children","volume":"52","author":"Mehta","year":"2022","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"10.1016\/j.jped.2026.101625_bib0007","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1590\/S0021-75572010000400007","article-title":"Oral food challenge test to confirm the diagnosis of cow's milk allergy","volume":"86","author":"Lins","year":"2010","journal-title":"J Pediatr (Rio J)"},{"issue":"6","key":"10.1016\/j.jped.2026.101625_bib0008","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00431-014-2456-6","article-title":"Remaining symptoms in half the children treated for milk allergy","volume":"174","author":"Petrus","year":"2015","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.jped.2026.101625_bib0009","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jped.2023.08.003","article-title":"Outcomes and factors associated with tolerance in infants with non-IgE-mediated cow's milk allergy with gastrointestinal manifestations","volume":"100","author":"Vasconcelos","year":"2024","journal-title":"J Pediatr (Rio J)"},{"issue":"5","key":"10.1016\/j.jped.2026.101625_bib0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/pai.12905","article-title":"The impact of oral food challenges for food allergy on quality of life: a systematic review","volume":"29","author":"Kansen","year":"2018","journal-title":"Pediatr Allergy Immunol"},{"issue":"5","key":"10.1016\/j.jped.2026.101625_bib0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.anai.2016.02.016","article-title":"The economic effect and outcome of delaying oral food challenges","volume":"116","author":"Couch","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jped.2026.101625_bib0012","article-title":"Estimating cost-effectiveness of confirmatory oral food challenges in the diagnosis of children with food allergy","volume":"6","author":"Alsaggaf","year":"2019","journal-title":"Glob Pediatr Health"},{"issue":"1","key":"10.1016\/j.jped.2026.101625_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15586\/aei.v50i1.471","article-title":"Outcome of food intake and nutritional status after discontinuation of a cow's-milk-free diet post negative oral food challenge in infants and children","volume":"50","author":"de Faria","year":"2022","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"12","key":"10.1016\/j.jped.2026.101625_bib0014","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1080\/13696998.2016.1211390","article-title":"Amino acid formula as a new strategy for diagnosing cow's milk allergy in infants: is it cost-effective?","volume":"19","author":"Morais","year":"2016","journal-title":"J Med Econ"},{"key":"10.1016\/j.jped.2026.101625_bib0015","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2147\/CEOR.S113448","article-title":"Relative cost-effectiveness of using an extensively hydrolyzed casein formula in managing infants with cow's milk allergy in Brazil","volume":"8","author":"Guest","year":"2016","journal-title":"Clinicoecon Outcomes Res"},{"issue":"4","key":"10.1016\/j.jped.2026.101625_bib0016","doi-asserted-by":"crossref","first-page":"68","DOI":"10.15586\/aei.v53i4.1323","article-title":"Real-life management of gastrointestinal cow's milk protein allergy in Brazilian infants","volume":"52","author":"Rodrigues","year":"2025","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"1","key":"10.1016\/j.jped.2026.101625_bib0017","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13690-023-01094-3","article-title":"Evolution of nutritional status and associated factors among formula-fed infants with cow's milk protein allergy in a government program","volume":"81","author":"Taveira","year":"2023","journal-title":"Arch Public Health"},{"issue":"2","key":"10.1016\/j.jped.2026.101625_bib0018","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1590\/S0103-05822013000200004","article-title":"Clinical and follow up assessment of children in a program directed at the use of formulas for cow's milk protein allergy","volume":"31","author":"Aguiar","year":"2013","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.jped.2026.101625_bib0019","series-title":"Anais do 19\u00b0 Congresso Brasileiro de Gastroenterologia e Hepatologia Pedi\u00e1tricas; 5\u00b0 Congresso Brasileiro de Nutrologia Pedi\u00e1trica; 2\u00aa Simp\u00f3sio de Suporte Nutricional Pedi\u00e1trico","article-title":"D\u00e9ficit antropom\u00e9trico em lactentes com alergia ao leite de vaca no Brasil: revis\u00e3o sistem\u00e1tica e metan\u00e1lise de preval\u00eancia utilizando dados individuais","author":"Rodrigues","year":"2024"},{"issue":"6","key":"10.1016\/j.jped.2026.101625_bib0020","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2222.2007.02724.x","article-title":"The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review","volume":"37","author":"Hill","year":"2007","journal-title":"Clin Exp Allergy"},{"issue":"11","key":"10.1016\/j.jped.2026.101625_bib0021","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s40273-020-00937-z","article-title":"Estimating transition probabilities from published evidence: a tutorial for decision modelers","volume":"38","author":"Gidwani","year":"2020","journal-title":"Pharmacoeconomics"},{"issue":"4","key":"10.1016\/j.jped.2026.101625_bib0022","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jaci.2005.06.018","article-title":"Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status","volume":"116","author":"Saarinen","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jped.2026.101625_bib0023","series-title":"National commission for the incorporation of technologies in the unified health system \u2013 conitec","year":"2022"},{"key":"10.1016\/j.jped.2026.101625_bib0024","series-title":"SIGTAP - System for the management of the table of procedures, medications, and OPM of SUS","year":"2024"},{"key":"10.1016\/j.jped.2026.101625_bib0025","series-title":"Database of the hospital information system (SIH) of the unified health system (SUS)","year":"2024"},{"key":"10.1016\/j.jped.2026.101625_bib0026","volume":"132","year":"2014"},{"issue":"10","key":"10.1016\/j.jped.2026.101625_bib0027","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/apa.13044","article-title":"Health-related quality of life in children with objectively diagnosed staple food allergy assessed with a disease-specific questionnaire","volume":"104","author":"Protudjer","year":"2015","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.jped.2026.101625_bib0028","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3111\/13696998.2010.482909","article-title":"Budget impact of managing cow milk allergy in the Netherlands","volume":"13","author":"Sladkevicius","year":"2010","journal-title":"J Med Econ"},{"issue":"11","key":"10.1016\/j.jped.2026.101625_bib0029","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1001\/jamapediatrics.2013.2376","article-title":"The economic impact of childhood food allergy in the United States","volume":"167","author":"Gupta","year":"2013","journal-title":"JAMA Pediatr"},{"issue":"6","key":"10.1016\/j.jped.2026.101625_bib0030","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1017\/S0007114521004165","article-title":"Feeding difficulties in children fed a cows' milk elimination diet","volume":"128","author":"Rodrigues","year":"2022","journal-title":"Br J Nutr"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755726001270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755726001270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:27:59Z","timestamp":1791016079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755726001270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S0021755726001270"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2026.101625","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cost-effectiveness of oral food challenge in managing cow's milk allergy under the Brazilian Public Health perspective","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2026.101625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}],"article-number":"101625"}}