{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:16:51Z","timestamp":1777108611412,"version":"3.51.4"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.jpeds.2004.06.041","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T17:53:40Z","timestamp":1097690020000},"page":"536-541","source":"Crossref","is-referenced-by-count":35,"title":["Optic nerve size evaluated by magnetic resonance imaging in children with optic nerve hypoplasia, multiple pituitary hormone deficiency, isolated growth hormone deficiency, and idiopathic short stature"],"prefix":"10.1016","volume":"145","author":[{"given":"Niels Holtum","family":"Birkeb\u00e6k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neville Bryce","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Russell","family":"Grigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smeeta","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Margaret","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Anthony","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian Christopher","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Ellis","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2004.06.041_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0161-6420(97)30286-3","article-title":"The clinical, neuroradiographic, and endocrinologic profile of patients with bilateral optic nerve hypoplasia","volume":"104","author":"Siatkowski","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jpeds.2004.06.041_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/archopht.1993.01090010070029","article-title":"Optic nerve hypoplasia. Clinical significance of associated central nervous system abnormalities on magnetic resonance imaging","volume":"111","author":"Brodsky","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib3","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1210\/jc.2003-030527","article-title":"Endocrine status in patients with optic nerve hypoplasia: relationship to midline central nervous system abnormalities and appearance of the hypothalamic-pituitary axis on magnetic resonance imaging","volume":"88","author":"Birkeb\u00e6k","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2004.06.041_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0039-6257(87)90069-5","article-title":"Optic nerve hypoplasia","volume":"32","author":"Lambert","year":"1987","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0896-6273(00)80373-6","article-title":"Netrin-1 and DDC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia","volume":"19","author":"Deiner","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.jpeds.2004.06.041_bib6","doi-asserted-by":"crossref","first-page":"R6","DOI":"10.1016\/S0960-9822(06)00007-8","article-title":"Axon guidance: netrin receptors are revealed","volume":"7","author":"Guthrie","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3928\/0191-3913-19880501-11","article-title":"The disc-macula distance to disc diameter ratio: a new test for confirming optic nerve hypoplasia in young children","volume":"25","author":"Alvarez","year":"1988","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.jpeds.2004.06.041_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/bjo.75.9.538","article-title":"Reappraisal of the ratio of disc to macula\/disc diameter in optic nerve hypoplasia","volume":"75","author":"Zeki","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib9","first-page":"425","article-title":"Optic nerve hypoplasia: septo-optic-pituitary dysplasia syndrome","volume":"79","author":"Acers","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.1016\/j.jpeds.2004.06.041_bib10","first-page":"443","article-title":"Radiologic features of septooptic dysplasia: de Morsier syndrome","volume":"1","author":"O'Dwyer","year":"1980","journal-title":"AJNR"},{"key":"10.1016\/j.jpeds.2004.06.041_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1091-8531(99)70079-0","article-title":"Diagnostic value of magnetic resonance imaging and planimetric measurement of optic disc size in confirming optic nerve hypoplasia","volume":"3","author":"Hellstrom","year":"1999","journal-title":"J AAPOS"},{"key":"10.1016\/j.jpeds.2004.06.041_bib12","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1001\/archopht.1990.01070130064032","article-title":"Optic nerve hypoplasia. Identification by magnetic resonance imaging","volume":"108","author":"Brodsky","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0887-2171(01)90002-2","article-title":"Imaging of the optic nerve and visual pathways","volume":"22","author":"Smith","year":"2001","journal-title":"Semin Ultrasoun CT MR"},{"key":"10.1016\/j.jpeds.2004.06.041_bib14","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1515\/JPEM.2000.13.9.1577","article-title":"Magnetic resonance imaging of the hypothalamic-pituitary axis in the diagnosis of growth hormone deficiency","volume":"13","author":"Tillmann","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2004.06.041_bib15","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0002-9394(14)73476-2","article-title":"Growth of the human optic disk and nerve during gestation, childhood, and early adulthood","volume":"116","author":"Rimmer","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jpeds.2004.06.041_bib16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0022-3476(05)81955-9","article-title":"Magnetic resonance imaging in the diagnosis of growth hormone deficiency","volume":"120","author":"Argyropoulou","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2004.06.041_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1067\/mpa.2001.118220","article-title":"Magnetic resonance diagnosis of congenital hypopituitarism in children with optic nerve hypoplasia","volume":"5","author":"Phillips","year":"2001","journal-title":"J AAPOS"},{"key":"10.1016\/j.jpeds.2004.06.041_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1034\/j.1600-0420.1998.760302.x","article-title":"Reference intervals of optic disc and retinal vessel variables in healthy children","volume":"76","author":"Hellstrom","year":"1998","journal-title":"Acta Ophthalmol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347604005414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347604005414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T14:32:51Z","timestamp":1624717971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347604005414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0022347604005414"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2004.06.041","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}