{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:29:32Z","timestamp":1790983772555,"version":"4.1.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.jpeds.2004.06.065","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T18:44:05Z","timestamp":1099939445000},"page":"698-700","source":"Crossref","is-referenced-by-count":54,"title":["Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor\u2013associated kinase 4"],"prefix":"10.1016","volume":"145","author":[{"given":"Anselm","family":"Enders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Pannicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Berner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Henneke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Radlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2004.06.065_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.coi.2003.11.013","article-title":"Inherited disorders of NF-kappaB-mediated immunity in man","volume":"16","author":"Puel","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jpeds.2004.06.065_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00130832-200312000-00006","article-title":"Primary immunodeficiencies associated with pneumococcal disease","volume":"3","author":"Picard","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2004.06.065_bib3","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1126\/science.1081902","article-title":"Pyogenic bacterial infections in humans with IRAK-4 deficiency","volume":"299","author":"Picard","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jpeds.2004.06.065_bib4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.20030701","article-title":"Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections","volume":"198","author":"Medvedev","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jpeds.2004.06.065_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.20022020","article-title":"Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen","volume":"197","author":"Kruetzmann","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jpeds.2004.06.065_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00431-002-0965-1","article-title":"Familial isolated congenital asplenia: a rare, frequently hereditary dominant condition, often detected too late as a cause of overwhelming pneumococcal sepsis: report of a new case and review of 31 others","volume":"161","author":"Gilbert","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2004.06.065_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(05)81598-7","article-title":"Subnormal serum concentrations of IgG2 in children with frequent infections associated with varied patterns of immunologic dysfunction","volume":"116","author":"Shackelford","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2004.06.065_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/CMR.4.3.359","article-title":"Infectious diseases associated with complement deficiencies","volume":"4","author":"Figueroa","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jpeds.2004.06.065_bib9","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.4049\/jimmunol.158.8.3959","article-title":"Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections","volume":"158","author":"Kuhns","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jpeds.2004.06.065_bib10","doi-asserted-by":"crossref","first-page":"13125","DOI":"10.1073\/pnas.95.22.13125","article-title":"Interleukin 12 deficiency associated with recurrent infections","volume":"95","author":"Haraguchi","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2004.06.065_bib11","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/clinids\/21.6.1390","article-title":"Pneumococcal meningitis in children: prognostic indicators and outcome","volume":"21","author":"Kornelisse","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2004.06.065_bib12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jpeds.2003.11.025","article-title":"Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses","volume":"144","author":"Day","year":"2004","journal-title":"J Pediatr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347604006316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347604006316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T02:10:53Z","timestamp":1682820653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347604006316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0022347604006316"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2004.06.065","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}