{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:14:53Z","timestamp":1774422893288,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.jpeds.2006.07.027","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T07:29:44Z","timestamp":1162970984000},"page":"634-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Surfactant phosphatidylcholine metabolism in neonates with meconium aspiration syndrome"],"prefix":"10.1016","volume":"149","author":[{"given":"Daphne J.","family":"Janssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgilio P.","family":"Carnielli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajsa","family":"Bohlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Hamvas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid H.","family":"Luijendijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Erik H.","family":"Bunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc J.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2006.07.027_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1651-2227.1993.tb12635.x","article-title":"Surfactant inhibition in experimental meconium aspiration","volume":"82","author":"Sun","year":"1993","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0002-9378(11)80003-7","article-title":"Inhibition of pulmonary surfactant function by meconium","volume":"164","author":"Moses","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2006.07.027_bib3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/PL00008344","article-title":"Inhibitory effect of meconium on pulmonary surfactant function tested in vitro using the stable microbubble test","volume":"159","author":"Oh","year":"2000","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1203\/00006450-199808000-00008","article-title":"Morphology andfunction of pulmonary surfactant inhibited by meconium","volume":"44","author":"Bae","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2006.07.027_bib5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3346\/jkms.1996.11.5.429","article-title":"In vitro effect of meconium on the physical surface properties and morphology of exogenous pulmonary surfactant","volume":"11","author":"Park","year":"1996","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jpeds.2006.07.027_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1067\/mpd.2001.109602","article-title":"Surfactant and surfactant inhibitors in meconium aspiration syndrome","volume":"138","author":"Dargaville","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-3476(05)82839-2","article-title":"Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation","volume":"116","author":"Lotze","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3476(05)81202-8","article-title":"Phospholipid and surfactant protein A concentrations in tracheal aspirates from infants requiring extracorporeal membrane oxygenation","volume":"121","author":"Bui","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3476(06)80131-9","article-title":"Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation","volume":"122","author":"Lotze","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib10","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1542\/peds.100.6.998","article-title":"Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration","volume":"100","author":"Cleary","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.07.027_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppul.1950160205","article-title":"Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model","volume":"16","author":"Davey","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpeds.2006.07.027_bib12","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/BF02532529","article-title":"Treatment of severe meconium aspiration syndrome with porcine surfactant","volume":"155","author":"Halliday","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1542\/peds.87.1.101","article-title":"Surfactant treatment of full-term newborns with respiratory failure","volume":"87","author":"Auten","year":"1991","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.07.027_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1542\/peds.92.1.135","article-title":"Surfactant therapy in full-term neonates with severe respiratory failure","volume":"92","author":"Khammash","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.07.027_bib15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/adc.80.3.248","article-title":"Surfactant treatment for acute respiratory distress syndrome","volume":"80","author":"Lopez-Herce","year":"1999","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2006.07.027_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-3476(98)70482-2","article-title":"Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure","volume":"132","author":"Lotze","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1542\/peds.97.1.48","article-title":"Surfactant replacement therapy for meconium aspiration syndrome","volume":"97","author":"Findlay","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.07.027_bib18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/00006450-199603000-00011","article-title":"Meconium increases surfactant secretion in isolated rat alveolar type II cells","volume":"39","author":"Higgins","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2006.07.027_bib19","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1164\/ajrccm.157.3.9612054","article-title":"Endogenous surfactant turnover in preterm infants measured with stable isotopes","volume":"157","author":"Bunt","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2006.07.027_bib20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1164\/rccm.2108028","article-title":"Surfactant synthesis and kinetics in infants with congenital diaphragmatic hernia","volume":"166","author":"Cogo","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2006.07.027_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0003-2697(75)90374-7","article-title":"Gas chromatographic determination of polyols and aldoses in human urine as polyacetates and aldonitrile polyacetates","volume":"63","author":"Pfaffenberger","year":"1975","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jpeds.2006.07.027_bib22","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"10.1016\/j.jpeds.2006.07.027_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02534120","article-title":"Improved separation of phospholipids in thin layer chromatography","volume":"15","author":"Touchstone","year":"1979","journal-title":"Lipids"},{"key":"10.1016\/j.jpeds.2006.07.027_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00003246-199803000-00035","article-title":"Prospective evaluation of surfactant composition in bronchoalveolar lavage fluid of infants with congenital diaphragmatic hernia and of age-matched controls","volume":"26","author":"IJsselstijn","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2006.07.027_bib25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm\/144.6.1376","article-title":"Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid","volume":"144","author":"Hallman","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jpeds.2006.07.027_bib26","doi-asserted-by":"crossref","first-page":"L735","DOI":"10.1152\/ajplung.00120.2001","article-title":"Pulmonary-specific expression of tumor necrosis factor-alpha alters surfactant lipid metabolism","volume":"282","author":"Carroll","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpeds.2006.07.027_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1067\/mpd.2003.94","article-title":"Surfactant phosphatidylcholine pool size in human neonates with congenital diaphragmatic hernia requiring ECMO","volume":"142","author":"Janssen","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib28","first-page":"184","article-title":"A dual stable isotope tracer method for the measurement of surfactant disaturated-phosphatidylcholine net synthesis in infants with congenital diaphragmatic hernia","volume":"56","author":"Cogo","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.07.027_bib29","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1097\/00003246-200010000-00001","article-title":"Treatment with exogenous surfactant stimulates endogenous surfactant synthesis in premature infants with respiratory distress syndrome","volume":"28","author":"Bunt","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2006.07.027_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1165\/ajrcmb\/8.3.258","article-title":"Influence of strain on [3H]thymidine incorporation, surfactant-related phospholipid synthesis, and cAMP levels in fetal type II alveolar cells","volume":"8","author":"Scott","year":"1993","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347606006895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347606006895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:51:20Z","timestamp":1758358280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347606006895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0022347606006895"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2006.07.027","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surfactant phosphatidylcholine metabolism in neonates with meconium aspiration syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2006.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}