{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:21:20Z","timestamp":1771845680673,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jpeds.2006.09.001","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T22:35:16Z","timestamp":1166826916000},"page":"46-50.e2","source":"Crossref","is-referenced-by-count":53,"title":["Indomethacin Prophylaxis for Preterm Infants: The Impact of 2 Multicentered Randomized Controlled Trials on Clinical Practice"],"prefix":"10.1016","volume":"150","author":[{"given":"Ronald I.","family":"Clyman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shampa","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Jobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2006.09.001_bib1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jama.289.9.1124","article-title":"Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely-low\u2013birth weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms","volume":"289","author":"Schmidt","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2006.09.001_bib2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1542\/peds.2004-0667","article-title":"Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents","volume":"115","author":"Laptook","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1542\/peds.105.6.1216","article-title":"Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993\u20131994","volume":"105","author":"Vohr","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0022-3476(05)81204-1","article-title":"Effects of intraventricular hemorrhage and socioeconomic status on perceptual, cognitive, and neurologic status of low birth weight infants at 5 years of age","volume":"121","author":"Vohr","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0029-7844(97)00429-8","article-title":"Outcome of infants born at 24\u201326 weeks\u2019 gestation","volume":"90","author":"Piecuch","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2006.09.001_bib6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1542\/peds.82.4.533","article-title":"Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants","volume":"82","author":"Bandstra","year":"1988","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0022-3476(89)80300-2","article-title":"Indomethacin reduces the risks of severe intraventricular hemorrhage","volume":"115","author":"Bada","year":"1989","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib8","first-page":"CD000174","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","author":"Fowlie","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpeds.2006.09.001_bib9","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0022-3476(85)80197-9","article-title":"Randomized indomethacin trial for prevention of intraventricular hemorrhage in very-low-birth weight infants","volume":"107","author":"Ment","year":"1985","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib10","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0022-3476(88)80225-7","article-title":"Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very-low-birth weight neonates","volume":"112","author":"Ment","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1542\/peds.93.4.543","article-title":"Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial","volume":"93","author":"Ment","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0022-3476(05)83191-9","article-title":"Low-dose indomethacin therapy and extension of intraventricular hemorrhage: a multicenter randomized trial","volume":"124","author":"Ment","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib13","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(90)93030-S","article-title":"Effects of indomethacin on cerebral haemodynamics in very preterm infants","volume":"335","author":"Edwards","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2006.09.001_bib14","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1203\/00006450-198511000-00009","article-title":"Effects of indomethacin upon cerebral hemodynamics of newborn pigs","volume":"19","author":"Leffler","year":"1985","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2006.09.001_bib15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1651-2227.1991.tb11918.x","article-title":"Effects of indomethacin on cerebral hemodynamics at rest and during endotracheal suctioning in preterm neonates","volume":"80","author":"Saliba","year":"1991","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.jpeds.2006.09.001_bib16","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","article-title":"Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants","volume":"344","author":"Schmidt","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2006.09.001_bib17","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-3476(96)80123-5","article-title":"Commentary","volume":"128","author":"Clyman","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib18","first-page":"456A","article-title":"Prevention and 18-month outcome of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms (TIPP) [abstract]","volume":"55","author":"Al Faleh","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2006.09.001_bib19","doi-asserted-by":"crossref","first-page":"F128","DOI":"10.1136\/adc.2003.046268","article-title":"Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era","volume":"90","author":"Hintz","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2006.09.001_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0095-5108(18)30637-7","article-title":"Intraventricular hemorrhage and brain injury in the premature infant: neuropathology and pathogenesis","volume":"16","author":"Volpe","year":"1989","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2006.09.001_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1055\/s-2003-42693","article-title":"Risk factors predicting vasopressor use after patent ductus arteriosus ligation","volume":"20","author":"Moin","year":"2003","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2006.09.001_bib22","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1136\/adc.2004.057638","article-title":"Is surgical ligation of patent ductus arteriosus necessary?","volume":"90","author":"Brooks","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2006.09.001_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/hrt.30.1.4","article-title":"Natural history of persistent ductus arteriosus","volume":"30","author":"Campbell","year":"1968","journal-title":"Br Heart J"},{"key":"10.1016\/j.jpeds.2006.09.001_bib24","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1542\/peds.111.4.e340","article-title":"School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial","volume":"111","author":"Vohr","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jpeds.2005.06.033","article-title":"Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome","volume":"147","author":"Miller","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2006.09.001_bib26","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1542\/peds.2005-1767","article-title":"Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks\u2019 gestation at birth","volume":"117","author":"Miller","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1542\/peds.105.3.485","article-title":"Outcome of children in the indomethacin intraventricular hemorrhage prevention trial","volume":"105","author":"Ment","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2006.09.001_bib28","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jpeds.2004.07.035","article-title":"Prevention of intraventricular hemorrhage by indomethacin in male preterm infants","volume":"145","author":"Ment","year":"2004","journal-title":"J Pediatr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347606008420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347606008420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T06:13:58Z","timestamp":1683699238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347606008420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0022347606008420"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2006.09.001","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}