{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:07:14Z","timestamp":1794330434186,"version":"4.9.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.jpeds.2008.04.028","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T04:33:26Z","timestamp":1213677206000},"page":"484-490.e2","source":"Crossref","is-referenced-by-count":84,"title":["Interpretation of Biomarkers of Bone Metabolism in Children: Impact of Growth Velocity and Body Size in Healthy Children and Chronic Disease"],"prefix":"10.1016","volume":"153","author":[{"given":"Shamir","family":"Tuchman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Thayu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Shults","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon M.","family":"Burnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2008.04.028_bib1","first-page":"1353","article-title":"Physiology and pathophysiology of bone remodeling","volume":"45","author":"Raisz","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jpeds.2008.04.028_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa050336","article-title":"One year of alendronate after one year of parathyroid hormone(1-84) for osteoporosis","volume":"353","author":"Black","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2008.04.028_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S8756-3282(99)00087-3","article-title":"A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover","volume":"24","author":"Garnero","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.jpeds.2008.04.028_bib4","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.2165\/00003495-200666160-00001","article-title":"Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls","volume":"66","author":"Cremers","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.jpeds.2008.04.028_bib5","series-title":"Pediatric bone: biology and diseases","first-page":"339","article-title":"Biochemical markers of bone metabolism","author":"Schonau","year":"2003"},{"key":"10.1016\/j.jpeds.2008.04.028_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s001980070116","article-title":"Biochemical measurements of bone turnover in children and adolescents","volume":"11","author":"Szulc","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jpeds.2008.04.028_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2265.2002.01573.x","article-title":"Bone metabolism markers and bone mass in healthy pubertal boys and girls","volume":"57","author":"Van Coeverden","year":"2002","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jpeds.2008.04.028_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/jc.2006-1706","article-title":"Sex- and age-specific reference curves for serum markers of bone turnover in healthy children from 2 months to 18 years","volume":"92","author":"Rauchenzauner","year":"2007","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jpeds.2008.04.028_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jpeds.2005.12.027","article-title":"Are activated T cells regulators of bone metabolism in children with Crohn Disease?","volume":"148","author":"Sylvester","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jpeds.2006.01.036","article-title":"Bone loss in children with Crohn disease: evidence of \u201costeoimmune\u201d alterations","volume":"148","author":"Gordon","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib11","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1359\/jbmr.040908","article-title":"Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition","volume":"19","author":"Burnham","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jpeds.2008.04.028_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/01.MPG.0000153278.98861.32","article-title":"Altered bone mass in children at diagnosis of Crohn disease: a pilot study","volume":"40","author":"Harpavat","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/gut.34.7.939","article-title":"Growth and clinical course of children with Crohn's disease","volume":"34","author":"Griffiths","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.jpeds.2008.04.028_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1067\/mpd.2002.125907","article-title":"Self-assessment of sexual maturity status in children with Crohn's disease","volume":"141","author":"Schall","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02088471","article-title":"Validation of a self-administered instrument to assess stage of adolescent development","author":"Morris","year":"1980","journal-title":"J Youth Adolesc"},{"key":"10.1016\/j.jpeds.2008.04.028_bib16","series-title":"Growth at adolescence","author":"Tanner","year":"1962"},{"key":"10.1016\/j.jpeds.2008.04.028_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1542\/peds.109.1.45","article-title":"Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version","volume":"109","author":"Ogden","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2008.04.028_bib18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/ibd.20149","article-title":"Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease","volume":"13","author":"Thayu","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpeds.2008.04.028_bib19","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib20","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1359\/jbmr.1998.13.10.1602","article-title":"A longitudinal study of bone gain in pubertal girls: anthropometric and biochemical correlates","volume":"13","author":"Cadogan","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jpeds.2008.04.028_bib21","first-page":"1060","article-title":"Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects","volume":"75","author":"Thientz","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2008.04.028_bib22","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1359\/jbmr.1997.12.10.1714","article-title":"Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females","volume":"12","author":"Weaver","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jpeds.2008.04.028_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1365-2265.1994.tb03019.x","article-title":"Biochemical markers of bone turnover in girls during puberty","volume":"40","author":"Blumsohn","year":"1994","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jpeds.2008.04.028_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1651-2227.1997.tb08855.x","article-title":"Serum procollagen I carboxyterminal propeptide (PICP) levels through puberty: relationship to height velocity and serum hormone levels","volume":"86","author":"Rotteveel","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib25","first-page":"2056","article-title":"Serum bone alkaline phosphatase isoenzyme levels in normal children and children with growth hormone(GH) deficiency: a potential marker of bone formation and response to GH therapy","volume":"82","author":"Tobiume","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"10.1016\/j.jpeds.2008.04.028_bib26","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1542\/peds.2006-2023J","article-title":"Glucocorticoid-induced osteoporosis in children: impact of the underlying disease","volume":"119","author":"Leonard","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2008.04.028_bib27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/00005176-200211000-00010","article-title":"Effects of serum from children with newly diagnosed Crohn disease on primary cultures of rat osteoblasts","volume":"35","author":"Varghese","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00005176-199703000-00011","article-title":"Alterations in bone metabolism in children with inflammatory bowel eisease: an in vitro study","volume":"24","author":"Hyams","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/rheumatology\/33.3.224","article-title":"Effects of cytokines on alkaline phosphatase and osteocalcin production, calcification and calcium release by human ostoblastics cells","volume":"33","author":"Kuroki","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.jpeds.2008.04.028_bib30","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1177\/014860719902300506","article-title":"Cytokines and inflammatory bowel disease: a review","volume":"23","author":"McClane","year":"1999","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.jpeds.2008.04.028_bib31","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat Rev Genetics"},{"key":"10.1016\/j.jpeds.2008.04.028_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000091299","article-title":"Infliximab therapy improves the bone metabolism in fistulizing Crohn's disease","volume":"24","author":"Miheller","year":"2006","journal-title":"Dig Dis"},{"key":"10.1016\/j.jpeds.2008.04.028_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1365-2036.2004.02152.x","article-title":"Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease","volume":"20","author":"Franchimont","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2008.04.028_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ibd.20006","article-title":"Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease","volume":"13","author":"Sylvester","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jpeds.2008.04.028_bib35","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI112234","article-title":"Estimation of bone turnover evaluated by 47Ca-kinetics","volume":"76","author":"Charles","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpeds.2008.04.028_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jbmr.5650080202","article-title":"Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry","volume":"8","author":"Eriksen","year":"1993","journal-title":"J Bone Miner Res"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347608003041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347608003041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T15:56:07Z","timestamp":1545926167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347608003041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0022347608003041"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2008.04.028","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}