{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:59:21Z","timestamp":1786993161193,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.jpeds.2009.01.073","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T06:44:53Z","timestamp":1242974693000},"page":"205-210.e1","source":"Crossref","is-referenced-by-count":39,"title":["High-Dose Continuous Nebulized Levalbuterol for Pediatric Status Asthmaticus: A Randomized Trial"],"prefix":"10.1016","volume":"155","author":[{"given":"Timothy","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"McGintee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj K.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pawlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Zorc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2009.01.073_bib1","first-page":"1","article-title":"Surveillance for asthma\u2013United States, 1960-1995","volume":"47","author":"Mannino","year":"1998","journal-title":"MMWR CDC Surveill Summ"},{"key":"10.1016\/j.jpeds.2009.01.073_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1067\/mai.2000.109426","article-title":"Trends in the cost of illness for asthma in the United States, 1985-1994","volume":"106","author":"Weiss","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1542\/peds.86.4.509","article-title":"Nebulized albuterol in acute childhood asthma: comparison of two doses","volume":"86","author":"Schuh","year":"1990","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2009.01.073_bib4","series-title":"National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma","year":"2007"},{"key":"10.1016\/j.jpeds.2009.01.073_bib5","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1542\/peds.106.5.1006","article-title":"Effectiveness of a clinical pathway for inpatient asthma management","volume":"106","author":"Johnson","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2009.01.073_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/archpedi.152.10.977","article-title":"A cost-saving algorithm for children hospitalized for status asthmaticus","volume":"152","author":"McDowell","year":"1998","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1164\/rccm.2606001","article-title":"(R)-albuterol for asthma: pro [a.k.a. (S)-albuterol for asthma: con]","volume":"174","author":"Ameredes","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1164\/rccm.2606003","article-title":"Treatment with (R)-albuterol has no advantage over racemic albuterol","volume":"174","author":"Barnes","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib9","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0091-6749(99)70276-9","article-title":"The asthma-like pharmacology and toxicology of (S)-isomers of beta agonists","volume":"104","author":"Handley","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1124\/mol.53.3.347","article-title":"(S)-albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle","volume":"53","author":"Mitra","year":"1998","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1365-2222.2005.02347.x","article-title":"Effects of (R)- and (S)-isomers of beta-adrenergic agonists on eosinophil response to interleukin-5","volume":"35","author":"Volcheck","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jpeds.2009.01.073_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/pupt.1999.0217","article-title":"Pharmacokinetics and pharmacodynamics of cumulative single doses of inhaled salbutamol enantiomers in asthmatic subjects","volume":"12","author":"Gumbhir-Shah","year":"1999","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2009.01.073_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0091-6749(98)70332-X","article-title":"Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma","volume":"102","author":"Nelson","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib14","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1067\/mai.2001.120134","article-title":"Low-dose levalbuterol in children with asthma: safety and efficacy in comparison with placebo and racemic albuterol","volume":"108","author":"Milgrom","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1067\/mai.2001.119152","article-title":"The therapeutic ratio of R-albuterol is comparable with that of R(S)-albuterol in asthmatic patients","volume":"108","author":"Lotvall","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2009.01.073_bib16","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1185\/030079906X112534","article-title":"Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial","volume":"22","author":"Berger","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jpeds.2009.01.073_bib17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1067\/S0022-3476(03)00493-1","article-title":"Comparison of racemic albuterol and levalbuterol for treatment of acute asthma","volume":"143","author":"Carl","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2009.01.073_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.annemergmed.2005.02.001","article-title":"Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma","volume":"46","author":"Qureshi","year":"2005","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/01.pec.0000169433.91196.6a","article-title":"Levalbuterol versus racemic albuterol in the treatment of acute exacerbation of asthma in children","volume":"21","author":"Hardasmalani","year":"2005","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jpeds.2009.01.073_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1081\/JAS-120018630","article-title":"Interrater agreement in the clinical evaluation of acute pediatric asthma","volume":"40","author":"Stevens","year":"2003","journal-title":"J Asthma"},{"key":"10.1016\/j.jpeds.2009.01.073_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1197\/j.aem.2003.07.015","article-title":"Performance of a novel clinical score, the Pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma","volume":"11","author":"Gorelick","year":"2004","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib22","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1001\/archpedi.156.12.1199","article-title":"Comparability of acute asthma severity assessments by parents and respiratory therapists","volume":"156","author":"Gorelick","year":"2002","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ajem.2006.01.027","article-title":"A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adults","volume":"24","author":"Nowak","year":"2006","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jpeds.2009.01.073_bib24","first-page":"CD001115","article-title":"Continuous versus intermittent beta-agonists for acute asthma","volume":"4","author":"Camargo","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpeds.2009.01.073_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.pec.0000106239.72265.16","article-title":"Difficulty in obtaining peak expiratory flow measurements in children with acute asthma","volume":"20","author":"Gorelick","year":"2004","journal-title":"Pediatr Emerg Care"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347609001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347609001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T04:40:32Z","timestamp":1684989632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347609001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0022347609001139"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2009.01.073","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}