{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:59:19Z","timestamp":1786993159924,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.jpeds.2009.10.012","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T04:08:13Z","timestamp":1261454893000},"page":"645-650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Prevalence of Intracardiac Shunting in Children with Sickle Cell Disease and Stroke"],"prefix":"10.1016","volume":"156","author":[{"given":"Michael M.","family":"Dowling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zora R.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Boger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ramaciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2009.10.012_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1212\/WNL.51.1.169","article-title":"Stroke in children and sickle-cell disease: Baltimore-Washington Cooperative Young Stroke Study","volume":"51","author":"Earley","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1148\/radiol.2281020943","article-title":"Brain imaging findings in pediatric patients with sickle cell disease","volume":"228","author":"Steen","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.hoc.2004.07.004","article-title":"Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemia","volume":"18","author":"Quinn","year":"2004","journal-title":"Hematol Oncol Clin N Am"},{"key":"10.1016\/j.jpeds.2009.10.012_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2009.10.012_bib5","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1212\/WNL.55.8.1172","article-title":"Interatrial septal abnormalities and stroke: a metaanalysis of case-control studies","volume":"55","author":"Overell","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib6","first-page":"999","article-title":"Patent foramen ovale and unexplained ischemic cerebrovascular events in children","volume":"70","author":"Benedik","year":"2007","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.jpeds.2009.10.012_bib7","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1182\/blood.V83.11.3107.3107","article-title":"Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia","volume":"83","author":"Vichinsky","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2009.10.012_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0887-8994(94)00108-E","article-title":"Nontraumatic fat embolism syndrome in sickle cell anemia","volume":"12","author":"Horton","year":"1995","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4065\/81.5.615","article-title":"Paradoxical emboli in children and young adults: role of atrial septal defect and patent foramen ovale device closure","volume":"81","author":"Bartz","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jpeds.2009.10.012_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7326\/0003-4819-134-1-200101020-00009","article-title":"Relation between directly detected patent foramen ovale and ischemic brain lesions in sport divers","volume":"134","author":"Schwerzmann","year":"2001","journal-title":"Ann Internal Med"},{"key":"10.1016\/j.jpeds.2009.10.012_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.echo.2007.08.030","article-title":"Sensitivity for detection of patent foramen ovale increased with increasing number of contrast injections: a descriptive study with contrast transesophageal echocardiography","volume":"21","author":"Johansson","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2009.10.012_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2009.10.012_bib13","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1526-4610.2005.00260.x","article-title":"Use of ICHD-II criteria in the diagnosis of pediatric migraine","volume":"45","author":"Hershey","year":"2005","journal-title":"Headache"},{"key":"10.1016\/j.jpeds.2009.10.012_bib14","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1212\/WNL.57.11.2034","article-title":"PedMIDAS: development of a questionnaire to assess disability of migraines in children","volume":"75","author":"Hershey","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0025-6196(12)60336-X","article-title":"Incidence and size of patent foramen ovale during first 10 decades of life: an autopsy study of 965 normal hearts","volume":"59","author":"Hagen","year":"1984","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jpeds.2009.10.012_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccl.2004.10.006","article-title":"Patent foramen ovale and its relationship to stroke","volume":"23","author":"Cramer","year":"2005","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.jpeds.2009.10.012_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2006-923936","article-title":"Cryptogenic stroke in children: possible role of patent foramen ovale","volume":"37","author":"Agnetti","year":"2006","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.jpeds.2009.10.012_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ana.10423","article-title":"Investigation of risk factors in children with arterial ischemic stroke","volume":"53","author":"Ganesan","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib19","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1378\/chest.107.6.1504","article-title":"The incidence of patent foramen ovale in 1000 consecutive patients: a contrast transesophageal echocardiography study","volume":"107","author":"Fisher","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.jpeds.2009.10.012_bib20","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.amjcard.2003.11.031","article-title":"An echocardiographic survey of primary school children for bicuspid aortic valve","volume":"93","author":"Basso","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00008506-199801000-00002","article-title":"Doppler color-flow imaging: screeing of a patent foramen ovale in children scheduled for neurosurgery in the sitting position","volume":"10","author":"Fuchs","year":"1998","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/adc.2006.110098","article-title":"When to close a patent foramen ovale","volume":"93","author":"Kenny","year":"2008","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2009.10.012_bib23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.103.3.640","article-title":"Silent cerebral infarcts in sickle cell anemia: a risk factor analysis","volume":"103","author":"Kinney","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2009.10.012_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2141.2006.06417.x","article-title":"Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease","volume":"136","author":"Machado","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1540-8183.2003.08001.x","article-title":"Transcatheter closure of patent foramen ovale: a new migraine treatment?","volume":"16","author":"Morandi","year":"2003","journal-title":"J Intervent Cardiol"},{"key":"10.1016\/j.jpeds.2009.10.012_bib26","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1212\/01.WNL.0000120756.25236.37","article-title":"Closure of a patent foramen ovale is associated with a decrease in prevalence of migraine","volume":"62","author":"Post","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib27","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1212\/01.WNL.0000120677.64217.A9","article-title":"Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks","volume":"62","author":"Schwerzmann","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2009.10.012_bib28","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.echo.2007.06.001","article-title":"Evaluation of 107 patients with sickle cell anemia through tissue Doppler and myocardial performance index","volume":"21","author":"Caldas","year":"2008","journal-title":"J Am Soc Echocardiogr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347609010269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347609010269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:52:25Z","timestamp":1758358345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347609010269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0022347609010269"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2009.10.012","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10905958.11833059","asserted-by":"object"}]},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of Intracardiac Shunting in Children with Sickle Cell Disease and Stroke","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2009.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}