{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:52:15Z","timestamp":1789825935325,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.jpeds.2010.11.011","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T09:16:45Z","timestamp":1295083005000},"page":"e35-e39","source":"Crossref","is-referenced-by-count":39,"special_numbering":"S","title":["Hemostasis and Platelet Dysfunction in Asphyxiated Neonates"],"prefix":"10.1016","volume":"158","author":[{"given":"Mary E.","family":"Bauman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Patricia","family":"Massicotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2010.11.011_bib1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1126\/science.145.3638.1310","article-title":"Waterfall Sequence For Intrinsic Blood Clotting","volume":"145","author":"Davie","year":"1964","journal-title":"Science"},{"key":"10.1016\/j.jpeds.2010.11.011_bib2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/202498a0","article-title":"An Enzyme Cascade In The Blood Clotting Mechanism, And It\u2019s Function As A Biochemical Amplifier","volume":"202","author":"Macfarlane","year":"1964","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2010.11.011_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11239-005-3118-3","article-title":"Cell-based models of coagulation: a paradigm in evolution","volume":"20","author":"Becker","year":"2005","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.jpeds.2010.11.011_bib4","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1055\/s-0037-1615947","article-title":"A cell-based model of hemostasis","volume":"85","author":"Hoffman","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib5","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1046\/j.1538-7836.2003.00260.x","article-title":"Von Willebrand factor, platelets and endothelial cell interactions","volume":"1","author":"Ruggeri","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/09537100120068170","article-title":"The platelet release reaction: Granules\u2019 constituents, secretion and functions","volume":"12","author":"Rendu","year":"2001","journal-title":"Platelets"},{"key":"10.1016\/j.jpeds.2010.11.011_bib7","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","article-title":"Development of the human coagulation system in the healthy premature infant","volume":"72","author":"Andrew","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2010.11.011_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood.V70.1.165.165","article-title":"Development of the human coagulation system in the full-term infant","volume":"70","author":"Andrew","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2010.11.011_bib9","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"Andrew","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2010.11.011_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ppedcard.2005.09.002","article-title":"Maturation of the coagulation system during childhood","volume":"21","author":"Kuhle","year":"2005","journal-title":"Progress in Pediatric Cardiology"},{"key":"10.1016\/j.jpeds.2010.11.011_bib11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1055\/s-0038-1648971","article-title":"Thrombin regulation in children differs from adults in the absence and presence of heparin","volume":"72","author":"Andrew","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-0038-1645680","article-title":"Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin","volume":"63","author":"Andrew","year":"1990","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib13","doi-asserted-by":"crossref","unstructured":"Puckett RM, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane database of systematic reviews (Online) 2000.","DOI":"10.1002\/14651858.CD002776"},{"key":"10.1016\/j.jpeds.2010.11.011_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00043426-198722000-00002","article-title":"Mean platelet volume and platelet distribution width in the neonate","volume":"9","author":"Patrick","year":"1987","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpeds.2010.11.011_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/09537100400016862","article-title":"Neonatal platelets from cord blood and peripheral blood","volume":"16","author":"Sitaru","year":"2005","journal-title":"Platelets"},{"key":"10.1016\/j.jpeds.2010.11.011_bib16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1203\/00006450-199905010-00014","article-title":"Impaired signal transduction in neonatal platelets","volume":"45","author":"Israels","year":"1999","journal-title":"Pediatric Research"},{"key":"10.1016\/j.jpeds.2010.11.011_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-2003-42587","article-title":"Neonatal platelet function","volume":"29","author":"Israels","year":"2003","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2007-996049","article-title":"Platelet function in the newborn","volume":"24","author":"Michelson","year":"1998","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"10.1016\/j.jpeds.2010.11.011_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000155613","article-title":"Collagen\/endogenous thrombin-induced platelet aggregation in cord versus adult whole blood","volume":"95","author":"Cvirn","year":"2009","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2010.11.011_bib20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s004310050748","article-title":"Hyporeactivity of neonatal platelets is not caused by preactivation during birth","volume":"156","author":"Grosshaupt","year":"1997","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.011_bib21","doi-asserted-by":"crossref","first-page":"20A","DOI":"10.1016\/j.amjcard.2008.11.019","article-title":"Methods for the measurement of platelet function","volume":"103","author":"Michelson","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2010.11.011_bib22","series-title":"Child Health and Development: Health of the Newborn. In: World Health Organization; 1991","year":"1991"},{"key":"10.1016\/j.jpeds.2010.11.011_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1651-2227.1997.tb08839.x","article-title":"Plasma thrombomodulin level in newborn infants with and without perinatal asphyxia.[see comment]","volume":"86","author":"Nako","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2010.11.011_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14767050701232596","article-title":"Nucleated red blood cell and platelet counts in asphyxiated neonates sufficient to result in permanent neurologic impairment","volume":"20","author":"Phelan","year":"2007","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2010.11.011_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0022-3476(86)81059-9","article-title":"Frequency and mechanism of neonatal thrombocytopenia","volume":"108","author":"Castle","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.011_bib26","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1542\/peds.99.5.672","article-title":"Number and activation of circulating polymorphonuclear leukocytes and platelets are associated with neonatal respiratory distress syndrome severity","volume":"99","author":"Brus","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.011_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000241182","article-title":"Electrokinetic behaviour of cord blood platelets in acidosis: an in vitro study","volume":"35","author":"Kosztolanyi","year":"1979","journal-title":"Biol Neonate"},{"key":"10.1016\/j.jpeds.2010.11.011_bib28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1203\/01.pdr.0000214894.18097.c4","article-title":"Platelet dysfunction in asphyxiated newborn piglets resuscitated with 21% and 100% oxygen","volume":"59","author":"Cheung","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.011_bib29","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.shk.0000245028.47106.92","article-title":"Temporal platelet aggregatory function in hypoxic newborn piglets reoxygenated with 18%, 21%, and 100% oxygen","volume":"27","author":"Postma","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.jpeds.2010.11.011_bib30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.jp.7211287","article-title":"Thrombopoietin level is increased in the serum of asphyxiated neonates: a prospective controlled study","volume":"25","author":"Aly","year":"2005","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2010.11.011_bib31","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1651-2227.1997.tb14816.x","article-title":"Coagulation and fibrinolytic systems in the ill preterm newborn","volume":"86","author":"Mautone","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2010.11.011_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-0038-1642563","article-title":"The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbit","volume":"59","author":"Castle","year":"1988","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib33","first-page":"643","article-title":"[Neonatal hypoxia and hemocoagulative changes]","volume":"11","author":"Fichera","year":"1989","journal-title":"Pediatr Med Chir"},{"key":"10.1016\/j.jpeds.2010.11.011_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1055\/s-2007-996040","article-title":"Hypercoagulability and DIC in high-risk infants","volume":"24","author":"Suzuki","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jpeds.2010.11.011_bib35","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"NEJM"},{"key":"10.1016\/j.jpeds.2010.11.011_bib36","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1213\/ane.0b013e31817340ad","article-title":"Hypothermia and acidosis synergistically impair coagulation in human whole blood","volume":"106","author":"Dirkmann","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jpeds.2010.11.011_bib37","doi-asserted-by":"crossref","first-page":"H2680","DOI":"10.1152\/ajpheart.00425.2005","article-title":"Sustained hypothermia accelerates microvascular thrombus formation in mice","volume":"289","author":"Lindenblatt","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jpeds.2010.11.011_bib38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0140-6736(05)79127-3","article-title":"Inhaled nitric oxide and inhibition of platelet aggregation in critically ill neonates","volume":"351","author":"Cheung","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2010.11.011_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/SHK.0b013e318164e6c4","article-title":"The effect of dobutamine on platelet aggregatory function in newborn piglets with hypoxia and reoxygenation","volume":"30","author":"Al-Salam","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.jpeds.2010.11.011_bib40","doi-asserted-by":"crossref","first-page":"645S","DOI":"10.1378\/chest.08-0762","article-title":"Antithrombotic therapy in neonates and children: the Eighth ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"133","author":"Monagle","year":"2008","journal-title":"Chest"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347610009637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347610009637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T17:29:59Z","timestamp":1592242199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347610009637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0022347610009637"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2010.11.011","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}