{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:56:10Z","timestamp":1791327370186,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jpeds.2010.11.018","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T04:19:05Z","timestamp":1293769145000},"page":"919-923.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Relationship between Circulating Platelet Counts and Ductus Arteriosus Patency after Indomethacin Treatment"],"prefix":"10.1016","volume":"158","author":[{"given":"Nidhi A.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K.","family":"Hills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Waleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"McCurnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Seidner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Clyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2010.11.018_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000092870","article-title":"Mechanisms regulating the ductus arteriosus","volume":"89","author":"Clyman","year":"2006","journal-title":"Biol Neonate"},{"key":"10.1016\/j.jpeds.2010.11.018_bib2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0046-8177(81)80333-4","article-title":"The morphology of the human newborn ductus arteriosus: a reappraisal of its structure and closure with special reference to prostaglandin E1 therapy","volume":"12","author":"Silver","year":"1981","journal-title":"Hum. Pathol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-3476(95)70084-6","article-title":"Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin","volume":"127","author":"Weiss","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1203\/01.PDR.0000148278.64777.EF","article-title":"The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling","volume":"57","author":"Waleh","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.018_bib5","first-page":"R199","article-title":"VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus","volume":"282","author":"Clyman","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1203\/00006450-200202000-00017","article-title":"Vasa vasorum hypoperfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus","volume":"51","author":"Kajino","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.018_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm.2060","article-title":"Platelets contribute to postnatal occlusion of the ductus arteriosus","volume":"16","author":"Echtler","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.jpeds.2010.11.018_bib8","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1038\/bjp.2008.36","article-title":"Indomethacin promotes nitric oxide function in the ductus arteriosus in the mouse","volume":"153","author":"Sodini","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0022-3476(84)80135-3","article-title":"Prolonged bleeding time in preterm infants receiving indomethacin for PDA","volume":"105","author":"Corazza","year":"1984","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib10","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/j.1538-7836.2009.03582.x","article-title":"Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosis in vivo","volume":"7","author":"Struthmann","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.018_bib11","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1161\/CIRCULATIONAHA.106.616219","article-title":"Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction","volume":"113","author":"Gislason","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2010.11.018_bib12","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.106.181424","article-title":"Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association","volume":"115","author":"Antman","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2010.11.018_bib13","first-page":"763","article-title":"Predictors of failed closure of patent ductus arteriosus with indomethacin","volume":"47","author":"Boo","year":"2006","journal-title":"Singapore Med J"},{"key":"10.1016\/j.jpeds.2010.11.018_bib14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1542\/peds.2006-3124","article-title":"Patent ductus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity","volume":"119","author":"Chorne","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.018_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1022381506823","article-title":"1994-1996 U.S. singleton birth weight percentiles for gestational age by race, Hispanic origin, and gender","volume":"3","author":"Alexander","year":"1999","journal-title":"Matern Child Health J"},{"key":"10.1016\/j.jpeds.2010.11.018_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weight < 1500 grams","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib17","first-page":"441","article-title":"Thrombocytopenia in term infants: a population-based study","volume":"95","author":"Sainio","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/jp.2008.10","article-title":"Template bleeding times of 240 neonates born at 24 to 41 weeks gestation","volume":"28","author":"Del Vecchio","year":"2008","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-3476(05)81705-6","article-title":"A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants","volume":"123","author":"Andrew","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib20","series-title":"Primary immunodeficiency diseases: a molecular and genetic approach","article-title":"The Wiskott-Aldrich Syndrome in Primary Immunodeficiency Diseases","author":"Ochs","year":"2007"},{"key":"10.1016\/j.jpeds.2010.11.018_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/pbc.20282","article-title":"Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia","volume":"45","author":"Bussel","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpeds.2010.11.018_bib22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/sj.jp.7211509","article-title":"Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system","volume":"26","author":"Christensen","year":"2006","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0022-3476(86)81059-9","article-title":"Frequency and mechanism of neonatal thrombocytopenia","volume":"108","author":"Castle","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jpeds.2007.05.007","article-title":"Risk factors for persistent ductus arteriosus patency during indomethacin treatment","volume":"151","author":"Chorne","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.018_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1203\/PDR.0b013e3181ed8609","article-title":"Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency","volume":"68","author":"Waleh","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.018_bib26","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1164\/ajrccm.160.4.9810071","article-title":"Neonatal chronic lung disease in extremely immature baboons","volume":"160","author":"Coalson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2010.11.018_bib27","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1164\/ajrccm.162.5.9912145","article-title":"High-frequency oscillatory ventilation: effects on lung function, mechanics, and airway cytokines in the immature baboon model for neonatal chronic lung disease","volume":"162","author":"Yoder","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2010.11.018_bib28","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1164\/rccm.200502-230OC","article-title":"Effect of ductus ligation on cardiopulmonary function in premature baboons","volume":"172","author":"McCurnin","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2010.11.018_bib29","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1542\/peds.2007-2051","article-title":"Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung","volume":"121","author":"McCurnin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.018_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1203\/PDR.0b013e318163a8e4","article-title":"Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus","volume":"63","author":"Chang","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.018_bib31","doi-asserted-by":"crossref","first-page":"H2342","DOI":"10.1152\/ajpheart.2001.280.5.H2342","article-title":"Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus","volume":"280","author":"Bouayad","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jpeds.2010.11.018_bib32","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood-2002-09-2797","article-title":"Transcript profiling of human platelets using microarray and serial analysis of gene expression","volume":"101","author":"Gnatenko","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2010.11.018_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1074\/mcp.M300063-MCP200","article-title":"Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes","volume":"3","author":"McRedmond","year":"2004","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.jpeds.2010.11.018_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1538-7836.2006.01684.x","article-title":"Comparative RNA expression analyses from small-scale, single-donor platelet samples","volume":"4","author":"Hillmann","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jpeds.2010.11.018_bib35","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1161\/01.CIR.0000145159.16637.5D","article-title":"Prostaglandin E2\u2013mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control","volume":"110","author":"Waleh","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2010.11.018_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1203\/01.PDR.0000148278.64777.EF","article-title":"The role of monocyte-derived cells and inflammation in baboon ductus arteriosus remodeling","volume":"57","author":"Waleh","year":"2005","journal-title":"Pediatr Res"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347610009893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347610009893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:52:57Z","timestamp":1758358377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347610009893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0022347610009893"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2010.11.018","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between Circulating Platelet Counts and Ductus Arteriosus Patency after Indomethacin Treatment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2010.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}