{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:16:50Z","timestamp":1787159810603,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jpeds.2010.11.059","type":"journal-article","created":{"date-parts":[[2011,1,16]],"date-time":"2011-01-16T04:11:32Z","timestamp":1295151092000},"page":"897-903.e5","source":"Crossref","is-referenced-by-count":93,"title":["The Relationship between Early Concentrations of 25 Blood Proteins and Cerebral White Matter Injury in Preterm Newborns: The ELGAN Study"],"prefix":"10.1016","volume":"158","author":[{"given":"Alan","family":"Leviton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kuban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michael","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Paneth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raina","family":"Fichorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth N.","family":"Allred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2010.11.059_bib1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.clp.2008.07.011","article-title":"Cytokines and perinatal brain damage","volume":"35","author":"Dammann","year":"2008","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.earlhumdev.2009.08.060","article-title":"The ELGAN Study of the brain and related disorders in extremely low gestational age newborns","volume":"85","author":"O\u2019Shea","year":"2009","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2010.11.059_bib3","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00247-007-0605-z","article-title":"Observer variability assessing US scans of the preterm brain: the ELGAN Study","volume":"37","author":"Kuban","year":"2007","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1542\/peds.74.3.358","article-title":"Rationale for grading intracranial hemorrhage in premature infants","volume":"74","author":"Kuban","year":"1984","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib5","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1128\/IAI.00631-06","article-title":"Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells","volume":"74","author":"Fichorova","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jpeds.2010.11.059_bib6","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1021\/ac702628q","article-title":"Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study","volume":"80","author":"Fichorova","year":"2008","journal-title":"Anal Chem"},{"key":"10.1016\/j.jpeds.2010.11.059_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1469-8749.1991.tb05092.x","article-title":"The epidemiology of germinal matrix hemorrhage during the first half-day of life","volume":"33","author":"Leviton","year":"1991","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1542\/peds.91.6.1083","article-title":"Antenatal corticosteroids appear to reduce the risk of postnatal germinal matrix hemorrhage in intubated low birth weight newborns","volume":"91","author":"Leviton","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib9","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0022-3476(99)70285-4","article-title":"Hypothyroxinemia of prematurity and the risk of cerebral white matter damage","volume":"134","author":"Leviton","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.059_bib10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0002-9378(99)70344-3","article-title":"Antenatal corticosteroids and cranial ultrasound abnormalities","volume":"181","author":"Leviton","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1203\/00006450-199911000-00013","article-title":"Maternal infection, fetal inflammatory response, and brain damage in very low birthweight infants","volume":"46","author":"Leviton","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.059_bib12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1542\/peds.2004-0667","article-title":"Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents","volume":"115","author":"Laptook","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.2274","article-title":"The immunology of sepsis","volume":"214","author":"Sriskandan","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ajem.2007.10.031","article-title":"The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome","volume":"26","author":"Wang","year":"2008","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jpeds.2010.11.059_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-065X.2008.00721.x","article-title":"Systems biology of innate immunity","volume":"227","author":"Zak","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jpeds.2010.11.059_bib16","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1203\/01.PDR.0000182592.76702.E8","article-title":"Circulating interferon-gamma and white matter brain damage in preterm infants","volume":"58","author":"Hansen-Pupp","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.059_bib17","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(01)06723-X","article-title":"Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions","volume":"358","author":"Duggan","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2010.11.059_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1203\/01.PDR.0000148286.53572.95","article-title":"The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn","volume":"57","author":"Ellison","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.059_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1203\/PDR.0b013e3181bf5fab","article-title":"Microbiologic and histologic characteristics of the extremely preterm infant\u2019s placenta predict white matter damage and later cerebral palsy: the ELGAN Study","volume":"67","author":"Leviton","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.059_bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/oxfordjournals.aje.a112340","article-title":"Multivariate analysis of risk of perinatal telencephalic leucoencephalopathy","volume":"104","author":"Leviton","year":"1976","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1067\/S0022-3476(03)00357-3","article-title":"Defining the nature of the cerebral abnormalities in the premature infant: a qualitative magnetic resonance imaging study","volume":"143","author":"Inder","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.059_bib22","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1001\/jama.292.19.2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection","volume":"292","author":"Stoll","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2010.11.059_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpeds.2008.02.033","article-title":"Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term","volume":"153","author":"Shah","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.11.059_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1542\/peds.2007-2184","article-title":"Recurrent postnatal infections are associated with progressive white matter injury in premature infants","volume":"122","author":"Glass","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1203\/PDR.0b013e3181fed334","article-title":"The relationship between neonatal blood protein profiles and placenta histologic characteristics in ELGANs","volume":"69","author":"Hecht","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2010.11.059_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1651-2227.2007.00097.x","article-title":"Persistent neuro-inflammation in cerebral palsy: a therapeutic window of opportunity?","volume":"96","author":"Dammann","year":"2007","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2010.11.059_bib27","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1172\/JCI41911","article-title":"Trafficking of immune cells in the central nervous system","volume":"120","author":"Wilson","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpeds.2010.11.059_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0887-8994(96)00157-9","article-title":"Ventriculomegaly, delayed myelination, white matter hypoplasia, and \u201cperiventricular\u201d leukomalacia: how are they related?","volume":"15","author":"Leviton","year":"1996","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-2002-37089","article-title":"Adult stroke and perinatal brain damage: like grandparent, like grandchild?","volume":"33","author":"Leviton","year":"2002","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1586\/ern.09.151","article-title":"Clinical application of blood biomarkers in cerebrovascular disease","volume":"10","author":"El Husseini","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.jpeds.2010.11.059_bib31","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.2741\/2897","article-title":"Clinical significance of acute phase reaction in stroke patients","volume":"13","author":"Dziedzic","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jpeds.2010.11.059_bib32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nurt.2009.10.016","article-title":"Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury","volume":"7","author":"Ziebell","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jpeds.2010.11.059_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1742-2094-5-28","article-title":"Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury","volume":"5","author":"Lloyd","year":"2008","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jpeds.2010.11.059_bib34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/WCO.0b013e32832b4db3","article-title":"Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options","volume":"22","author":"Kleinig","year":"2009","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib35","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.4049\/jimmunol.0990015","article-title":"The unexpected pleiotropic activities of RANTES","volume":"182","author":"Levy","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jpeds.2010.11.059_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/00365540310015935","article-title":"Cytokine cascade in sepsis","volume":"35","author":"Cavaillon","year":"2003","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jpeds.2010.11.059_bib37","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.4049\/jimmunol.177.8.5077","article-title":"RANTES modulates TLR4-induced cytokine secretion in human peripheral blood monocytes","volume":"177","author":"Shahrara","year":"2006","journal-title":"J Immunol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761001053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761001053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T17:59:52Z","timestamp":1685901592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234761001053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S002234761001053X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2010.11.059","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}