{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:02:50Z","timestamp":1784350970171,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fondation Rumsey-Cartier"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jpeds.2010.12.050","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T09:33:02Z","timestamp":1298626382000},"page":"127-132.e1","source":"Crossref","is-referenced-by-count":51,"title":["Giant Cell Hepatitis with Autoimmune Hemolytic Anemia in Early Childhood: Long-Term Outcome in 16 Children"],"prefix":"10.1016","volume":"159","author":[{"given":"Giuseppe","family":"Maggiore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sciveres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Pacifico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Resti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Choulot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jacquemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2010.12.050_bib1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s100249900134","article-title":"Infantile liver giant cells: immunohistological study of their proliferative state and possible mechanisms of formation","volume":"2","author":"Koukoulis","year":"1999","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib2","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/jcp.2008.058560","article-title":"Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV\/HIV co-infection","volume":"61","author":"Micchelli","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJM199102143240705","article-title":"Syncytial giant-cell hepatitis: sporadic hepatitis with distinctive pathological features, a severe clinical course, and paramyxoviral features","volume":"324","author":"Phillips","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jpeds.2010.12.050_bib4","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1007\/s10620-006-9698-8","article-title":"Postinfantile giant cell hepatitis due to Hepatitis E virus along with the presence of autoantibodies","volume":"52","author":"Harmanci","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jpeds.2010.12.050_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa074479","article-title":"HHV-6A in syncytial giant-cell hepatitis","volume":"359","author":"Potenza","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2010.12.050_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/adc.56.1.64","article-title":"HBsAg-positive giant cell hepatitis with cirrhosis in a 10-month-old infant","volume":"56","author":"Shinozaki","year":"1981","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2010.12.050_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1600-0676.1996.tb00743.x","article-title":"Post-infantile giant cell hepatitis in patients with primary sclerosing cholangitis and autoimmune hepatitis","volume":"16","author":"Protzer","year":"1996","journal-title":"Liver"},{"key":"10.1016\/j.jpeds.2010.12.050_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1572-0241.2000.01863.x","article-title":"Syncytial giant-cell hepatitis due to autoimmune hepatitis type II (LKM1+) presenting as subfulminant hepatitis","volume":"95","author":"Ben-Ari","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0168-8278(00)80289-5","article-title":"Adult syncytial giant cell chronic hepatitis due to herbal remedy","volume":"33","author":"Fraquelli","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib10","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/hep.23539","article-title":"ATP8B1 and ABCB11 analysis in 62 children with normal gamma-glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): phenotypic differences between PFIC1 and PFIC2 and natural history","volume":"51","author":"Davit-Spraul","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jpeds.2010.12.050_bib11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0168-8278(97)80440-0","article-title":"Subfulminant syncytial giant cell hepatitis: recurrence after liver transplantation treated with ribavirin","volume":"26","author":"Durand","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1432-2277.1998.tb00980.x","article-title":"Recurrent postinfantile syncytial giant cell hepatitis after orthotopic liver transplantation","volume":"11","author":"Lerut","year":"1998","journal-title":"Transpl Int"},{"key":"10.1016\/j.jpeds.2010.12.050_bib13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/00004836-200105000-00024","article-title":"Recurrent, progressive giant cell hepatitis in two consecutive liver allografts in a middle-aged woman","volume":"32","author":"Nair","year":"2001","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1155\/2000\/807681","article-title":"A\u00a0case of giant cell hepatitis recurring after liver transplantation and treated with ribavirin","volume":"14","author":"Hassoun","year":"2000","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0022-3476(81)80388-5","article-title":"Severe giant cell hepatitis with autoimmune haemolytic anemia in early childhood","volume":"99","author":"Bernard","year":"1981","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1651-2227.1986.tb10339.x","article-title":"Plasma exchange: an important part of the therapeutic procedure in a child with autoimmune hemolytic anemia","volume":"75","author":"Imgrueth","year":"1986","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.jpeds.2010.12.050_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF01955929","article-title":"Coombs-positive giant cell hepatitis of infancy: effect of steroids and azathioprine therapy","volume":"150","author":"Brichard","year":"1991","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00005176-199310000-00015","article-title":"Early steroid therapy for the treatment of giant cell hepatitis with autoimmune hemolytic anemia","volume":"17","author":"Weinstein","year":"1993","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/15513819409022027","article-title":"Coombs-positive autoimmune hemolytic anemia and postinfantile giant cell hepatitis in children","volume":"14","author":"Perez-Atayde","year":"1994","journal-title":"Pediatr Pathol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib20","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/00000478-199408000-00007","article-title":"Recurrent and de novo giant cell hepatitis after orthotopic liver transplantation","volume":"18","author":"Pappo","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/adc.77.3.249","article-title":"Liver transplant for giant cell hepatitis with autoimmune haemolytic anaemia","volume":"77","author":"Melendez","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2010.12.050_bib22","first-page":"565","article-title":"Combination of steroid with azathioprine in treatment of giant cell autoimmune hepatitis","volume":"39","author":"Ero\u011flu","year":"1997","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/adc.78.4.e395","article-title":"Coombs positive giant cell hepatitis: a new feature of Evans\u2019 syndrome","volume":"78","author":"Hadzic","year":"1998","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2010.12.050_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00005176-200103000-00020","article-title":"Giant cell hepatitis with autoimmune hemolytic anemia and hemophagocytosis","volume":"32","author":"Hartman","year":"2001","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib25","first-page":"837","article-title":"Autoimmune hemolytic anemia with giant cell hepatitis: case report and review of the literature","volume":"26","author":"Gorelik","year":"2004","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib26","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.dld.2005.09.013","article-title":"Life -saving cyclophosphamide treatment in a girl with giant cell hepatitis and autoimmune haemolytic anaemia: case report and up-to-date on therapeutical options","volume":"38","author":"Vajro","year":"2006","journal-title":"Dig Liv Dis"},{"key":"10.1016\/j.jpeds.2010.12.050_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajh.20414","article-title":"Autoimmune haemolytic anemia in an infant with giant cell hepatitis","volume":"81","author":"Kashyap","year":"2006","journal-title":"Am J Haematol"},{"key":"10.1016\/j.jpeds.2010.12.050_bib28","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/MPG.0b013e31802e9739","article-title":"Giant cell hepatitis and autoimmune hemolytic anemia success-fully treated with Rituximab","volume":"44","author":"Miloh","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/MPG.0b013e318033169f","article-title":"Alemtuzumab for giant cell hepatitis with autoimmune hemolytic anemia","volume":"45","author":"Rovelli","year":"2007","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib30","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/lt.20930","article-title":"Bullous pemphigoid after liver transplantation for liver failure","volume":"12","author":"Kerkar","year":"2006","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jpeds.2010.12.050_bib31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0022-3476(84)80477-1","article-title":"Treatment of autoimmune chronic active hepatitis in childhood","volume":"104","author":"Maggiore","year":"1984","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2010.12.050_bib32","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0140-6736(01)06573-4","article-title":"Treatment of childhood autoimmune haemolytic anemia with rituximab","volume":"358","author":"Quartier","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2010.12.050_bib33","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S1542-3565(04)00354-4","article-title":"Features and outcome of autoimmune hepatitis type 2 presenting with isolated positivity for anti-liver cytosol antibody","volume":"2","author":"Bridoux-Henno","year":"2004","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611000059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611000059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T14:53:44Z","timestamp":1543935224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347611000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0022347611000059"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2010.12.050","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}