{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:57:50Z","timestamp":1792598270309,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"(National Institutes of Health","doi-asserted-by":"crossref","award":["R01NS062756"],"award-info":[{"award-number":["R01NS062756"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"crossref","award":["M01-RR13297"],"award-info":[{"award-number":["M01-RR13297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jpeds.2011.03.057","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T05:52:47Z","timestamp":1306043567000},"page":"152-154.e3","source":"Crossref","is-referenced-by-count":62,"title":["Pharmacokinetics of Levetiracetam in Neonates with Seizures"],"prefix":"10.1016","volume":"159","author":[{"given":"Stephanie L.","family":"Merhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt R.","family":"Schibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Sherwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jareen","family":"Meinzen-Derr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Balmakund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Vinks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2011.03.057_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pediatrneurol.2007.04.003","article-title":"Neonatal seizures: multicenter variability in current treatment practices","volume":"37","author":"Bartha","year":"2007","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2011.03.057_bib2","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.222550499","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","author":"Bittigau","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2011.03.057_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1056\/NEJM199002083220604","article-title":"Phenobarbital for febrile seizures\u2014effects on intelligence and on seizure recurrence","volume":"322","author":"Farwell","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2011.03.057_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.seizure.2007.02.004","article-title":"Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy","volume":"16","author":"Grosso","year":"2007","journal-title":"Seizure"},{"key":"10.1016\/j.jpeds.2011.03.057_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.seizure.2005.02.004","article-title":"Efficacy and safety of levetiracetam: an add-on trial in children with refractory epilepsy","volume":"14","author":"Grosso","year":"2005","journal-title":"Seizure"},{"key":"10.1016\/j.jpeds.2011.03.057_bib6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1046\/j.1528-1157.2002.13101.x","article-title":"Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial","volume":"43","author":"Glauser","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2011.03.057_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/0883073809348795","article-title":"Intravenous levetiracetam in children with seizures: a prospective safety study","volume":"25","author":"Ng","year":"2010","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2011.03.057_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/0883073807299973","article-title":"Levetiracetam for the treatment of neonatal seizures","volume":"22","author":"Shoemaker","year":"2007","journal-title":"J.Child Neurol"},{"key":"10.1016\/j.jpeds.2011.03.057_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.seizure.2010.01.003","article-title":"Levetiracetam in the treatment of neonatal seizures: a pilot study","volume":"19","author":"Furwentsches","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.jpeds.2011.03.057_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpn.2010.10.003","article-title":"Levetiracetam: safety and efficacy in neonatal seizures","volume":"15","author":"Ramantani","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jpeds.2011.03.057_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cca.2006.06.022","article-title":"Determination of levetiracetam in human plasma\/serum\/saliva by liquid chromatography-electrospray tandem mass spectrometry","volume":"375","author":"Guo","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jpeds.2011.03.057_bib12","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1046\/j.1528-1157.2001.41300.x","article-title":"Pharmacokinetic study of levetiracetam in children","volume":"42","author":"Pellock","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2011.03.057_bib13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1528-1167.2007.01090.x","article-title":"Pharmacokinetics of levetiracetam in infants and young children with epilepsy","volume":"48","author":"Glauser","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2011.03.057_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00003088-200443110-00002","article-title":"Clinical pharmacokinetics of levetiracetam","volume":"43","author":"Patsalos","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jpeds.2011.03.057_bib15","first-page":"25","article-title":"Mechanistic basis of using body size and maturation to predict clearance in humans. Drug Metab","volume":"24","author":"Anderson","year":"2009","journal-title":"Pharmacokinet"},{"key":"10.1016\/j.jpeds.2011.03.057_bib16","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1528-1167.2008.01981.x","article-title":"Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures","volume":"50","author":"Pina-Garza","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2011.03.057_bib17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF01113502","article-title":"The importance of modeling interoccasion variability in population pharmacokinetic analyses","volume":"21","author":"Karlsson","year":"1993","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1016\/j.jpeds.2011.03.057_bib18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00431-006-0189-x","article-title":"Population clinical pharmacology of children: modelling covariate effects","volume":"165","author":"Anderson","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2011.03.057_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpeds.2011.03.057_bib20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/j.1552-4604.1997.tb04326.x","article-title":"Stability and performance of a population pharmacokinetic model","volume":"37","author":"Ette","year":"1997","journal-title":"J Clin Pharmacol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611003490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611003490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T12:25:00Z","timestamp":1543753500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347611003490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0022347611003490"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2011.03.057","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}