{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:27Z","timestamp":1786993227939,"version":"build-2736575974"},"reference-count":16,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.jpeds.2011.12.031","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T03:43:06Z","timestamp":1327981386000},"page":"929-935.e1","source":"Crossref","is-referenced-by-count":88,"title":["Timing of Patent Ductus Arteriosus Treatment and Respiratory Outcome in Premature Infants: A Double-Blind Randomized Controlled Trial"],"prefix":"10.1016","volume":"160","author":[{"given":"Ilene R.S.","family":"Sosenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Florencia","family":"Fajardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Claure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bancalari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2011.12.031_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000092870","article-title":"Mechanisms regulating the ductus arteriosus","volume":"89","author":"Clyman","year":"2006","journal-title":"Biol Neonate"},{"key":"10.1016\/j.jpeds.2011.12.031_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/jp.2010.3","article-title":"Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?","volume":"30","author":"Benitz","year":"2010","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2011.12.031_bib3","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0022-3476(78)80382-5","article-title":"Bronchopulmonary dysplasia: possible relationship to pulmonary edema","volume":"92","author":"Brown","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2011.12.031_bib4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0022-3476(95)70362-4","article-title":"Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease","volume":"126","author":"Rojas","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2011.12.031_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0022-3476(96)70356-6","article-title":"Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 g or less","volume":"128","author":"Gonzalez","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2011.12.031_bib6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-3476(96)80123-5","article-title":"Recommendations for the postnatal use of indomethacin: an analysis of four separate treatment strategies","volume":"128","author":"Clyman","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2011.12.031_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1067\/mpd.2001.110528","article-title":"Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome","volume":"138","author":"Van Overmeire","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2011.12.031_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2307\/2530245","article-title":"A multiple testing procedure for clinical trials","volume":"35","author":"O\u2019Brien","year":"1979","journal-title":"Biometrics"},{"key":"10.1016\/j.jpeds.2011.12.031_bib9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1542\/peds.2005-1528","article-title":"Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 g or less","volume":"117","author":"Koch","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2011.12.031_bib10","doi-asserted-by":"crossref","first-page":"L222","DOI":"10.1152\/ajplung.00388.2002","article-title":"Expression of VEGF and its receptors Flt-1 and Flk-1\/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension","volume":"285","author":"Mata-Greenwood","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpeds.2011.12.031_bib11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1542\/peds.2007-2051","article-title":"Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung","volume":"121","author":"McCurnin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2011.12.031_bib12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0046-8177(98)90280-5","article-title":"Pathology of arrested acinar development in postsurfactant bronchopulmonary dysplasia","volume":"29","author":"Husain","year":"1998","journal-title":"Human Pathol"},{"key":"10.1016\/j.jpeds.2011.12.031_bib13","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","article-title":"Bronchopulmonary dysplasia: where have all the vessels gone? Role of angiogenic growth factors in chronic lung disease","volume":"175","author":"Thebaud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2011.12.031_bib14","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","article-title":"the TIPP investigators. Long term effects of indomethacin prophylaxis in extremely low birth weight infants","volume":"344","author":"Schmidt","year":"2001","journal-title":"New Engl J Med"},{"key":"10.1016\/j.jpeds.2011.12.031_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0029-1243371","article-title":"Safety and\u00a0effectiveness of indomethacin versus ibuprofen for treatment of the patent ductus arteriosus","volume":"27","author":"Katakam","year":"2010","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2011.12.031_bib16","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1136\/adc.2009.168682","article-title":"Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants","volume":"96","author":"Jones","year":"2011","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611013163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347611013163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T13:55:11Z","timestamp":1543240511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347611013163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0022347611013163"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2011.12.031","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}