{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:17:49Z","timestamp":1793089069231,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1K23HD060040-01"],"award-info":[{"award-number":["1K23HD060040-01"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R18AE000028-01"],"award-info":[{"award-number":["1R18AE000028-01"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jpeds.2012.01.053","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T17:21:18Z","timestamp":1331918478000},"page":"264-269.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Empiric Antifungal Therapy and Outcomes in Extremely Low Birth Weight Infants with Invasive Candidiasis"],"prefix":"10.1016","volume":"161","author":[{"given":"Rachel G.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Daniel K.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie G.","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Cotten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo J.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetha","family":"Shankaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary D.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy J.","family":"Auten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbot R.","family":"Laptook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar A.","family":"Carlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil N.","family":"Finer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz","family":"Duara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Schibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Ehrenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa P.","family":"Van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Ivan D.","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L.","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda B.","family":"Poindexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michael","family":"O'Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi L.","family":"Watterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Brian","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2 Pt 1","key":"10.1016\/j.jpeds.2012.01.053_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.110.2.285","article-title":"Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network","volume":"110","author":"Stoll","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.106.4.712","article-title":"When to suspect fungal infection in neonates: a clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia","volume":"106","author":"Benjamin","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib3","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1056\/NEJMoa010494","article-title":"Fluconazole prophylaxis against fungal colonization and infection in preterm infants","volume":"345","author":"Kaufman","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1542\/peds.109.1.34","article-title":"Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey","volume":"109","author":"Makhoul","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1542\/peds.2004-2292","article-title":"Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months","volume":"117","author":"Benjamin","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00005792-198205000-00003","article-title":"Fever in the pediatric and young adult patient with cancer: a prospective study of 1001 episodes","volume":"61","author":"Pizzo","year":"1982","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jpeds.2012.01.053_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0002-9343(82)90594-0","article-title":"Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia","volume":"72","author":"Pizzo","year":"1982","journal-title":"Am J Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib8","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/archinte.1988.00380120094019","article-title":"Hospital-acquired candidemia: the attributable mortality and excess length of stay","volume":"148","author":"Wey","year":"1988","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0732-8893(93)90020-8","article-title":"Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis: disseminated versus single-organ infection","volume":"17","author":"Berenguer","year":"1993","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jpeds.2012.01.053_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00006454-198201000-00005","article-title":"Systemic candidiasis: a study of 109 fatal cases","volume":"1","author":"Hughes","year":"1982","journal-title":"Pediatr Infect Dis"},{"key":"10.1016\/j.jpeds.2012.01.053_bib11","first-page":"321","article-title":"Fungal infections in iatrogenically compromised hosts","volume":"43","author":"Rex","year":"1998","journal-title":"Adv Intern Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib12","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF02185855","article-title":"Fungal blood cultures","volume":"8","author":"Telenti","year":"1989","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jpeds.2012.01.053_bib13","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/jac\/31.6.809","article-title":"Early diagnosis of systemic candidal infection","volume":"31","author":"Matthews","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jpeds.2012.01.053_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3476(96)70254-8","article-title":"Volume of blood required to detect common neonatal pathogens","volume":"129","author":"Schelonka","year":"1996","journal-title":"J Pediatr"},{"issue":"6 Pt 1","key":"10.1016\/j.jpeds.2012.01.053_bib15","first-page":"668","article-title":"Empiric antifungal therapy in febrile granulocytopenic patients","volume":"86","year":"1989","journal-title":"Am J Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib16","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1086\/597395","article-title":"Empiric versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial","volume":"48","author":"Cordonnier","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2012.01.053_bib17","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.ejca.2008.06.040","article-title":"Empiric antifungal therapy for patients with neutropenia and persistent fever: systematic review and meta-analysis","volume":"44","author":"Goldberg","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jpeds.2012.01.053_bib18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jac\/dkm212","article-title":"Adequacy of empiric antifungal therapy and effect on outcome among patients with invasive Candida species infections","volume":"60","author":"Parkins","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jpeds.2012.01.053_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1542\/peds.107.1.61","article-title":"Review of 49 neonates with acquired fungal sepsis: further characterization","volume":"107","author":"Makhoul","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00431-006-0088-1","article-title":"Empiric guidelines for treatment of Candida infection in high-risk neonates","volume":"165","author":"Procianoy","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2012.01.053_bib21","doi-asserted-by":"crossref","first-page":"e865","DOI":"10.1542\/peds.2009-3412","article-title":"Neonatal candidiasis: epidemiology, risk factors, and clinical judgment","volume":"126","author":"Benjamin","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib22","series-title":"Bayley Scales of Infant and Toddler Development","author":"Bayley","year":"1993"},{"key":"10.1016\/j.jpeds.2012.01.053_bib23","series-title":"Bayley Scales of Infant and Toddler Development","author":"Bayley","year":"2006"},{"issue":"8 Pt 2","key":"10.1016\/j.jpeds.2012.01.053_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.7326\/0003-4819-127-8_Part_2-199710151-00064","article-title":"Estimating causal effects from large data sets using propensity scores","volume":"127","author":"Rubin","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1542\/peds.99.3.489","article-title":"Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection","volume":"99","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/596757","article-title":"Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America","volume":"48","author":"Pappas","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2012.01.053_bib27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s15010-006-5113-9","article-title":"A prospective, randomized multicenter trial of the empiric addition of antifungal therapy for febrile neutropenic cancer patients: results of the Paul Ehrlich Society for Chemotherapy (PEG) Multicenter Trial II","volume":"34","author":"Schiel","year":"2006","journal-title":"Infection"},{"key":"10.1016\/j.jpeds.2012.01.053_bib28","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","article-title":"Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality","volume":"49","author":"Morrell","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jpeds.2012.01.053_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1086\/502469","article-title":"Antimicrobial use and the influence of inadequate empiric antimicrobial therapy on the outcomes of nosocomial bloodstream infections in a neonatal intensive care unit","volume":"25","author":"Apisarnthanarak","year":"2004","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jpeds.2012.01.053_bib30","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00006454-199806000-00014","article-title":"Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases","volume":"17","author":"Kossoff","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jpeds.2012.01.053_bib31","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa065733","article-title":"A multicenter, randomized trial of prophylactic fluconazole in preterm neonates","volume":"356","author":"Manzoni","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2012.01.053_bib32","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1542\/peds.2008-3008","article-title":"Antifungal prophylaxis: identification of preterm neonates at highest risk for invasive fungal infection","volume":"123","author":"Vendettuoli","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2012.01.053_bib33","doi-asserted-by":"crossref","first-page":"F429","DOI":"10.1136\/adc.2008.157123","article-title":"Oral nystatin prophylaxis and neonatal fungal infections","volume":"94","author":"Howell","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2012.01.053_bib34","doi-asserted-by":"crossref","first-page":"F275","DOI":"10.1136\/adc.2008.145359","article-title":"Prophylactic oral nystatin for preterm babies under 33 weeks gestation decreases fungal colonisation and invasive fungaemia","volume":"94","author":"Ganesan","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2012.01.053_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00006454-200203000-00013","article-title":"Infections diagnosed in the first year after pediatric stem cell transplantation","volume":"21","author":"Benjamin","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jpeds.2012.01.053_bib36","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/adc.2009.160283","article-title":"The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997","volume":"95","author":"Roberts","year":"2010","journal-title":"Arch Dis Child"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347612001114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347612001114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:54:13Z","timestamp":1758358453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347612001114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0022347612001114"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2012.01.053","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Empiric Antifungal Therapy and Outcomes in Extremely Low Birth Weight Infants with Invasive Candidiasis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2012.01.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}