{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:03:07Z","timestamp":1791349387729,"version":"4.3.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":288,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.jpeds.2012.05.058","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T06:36:35Z","timestamp":1340778995000},"page":"763-765","source":"Crossref","is-referenced-by-count":36,"title":["Tetralogy of Fallot is an Uncommon Manifestation of Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome"],"prefix":"10.1016","volume":"161","author":[{"given":"Raffaele","family":"Badolato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Amendola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia D.","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Bachelerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Donadieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2012.05.058_bib1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM196404022701402","article-title":"\u201cMyelokathexis\u201d: a new form of chronic granulocytopenia. Report of a case","volume":"270","author":"Zuelzer","year":"1964","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2012.05.058_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/(SICI)1096-8628(20000424)91:5<368::AID-AJMG10>3.0.CO;2-9","article-title":"WHIM syndrome, an autosomal dominant disorder: clinical, haematological, and molecular studies","volume":"91","author":"Gorlin","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jpeds.2012.05.058_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/156652411795677963","article-title":"Clinical and genetic features of warts, hypogammaglobulinemia, infections and myelokathexis (WHIM) syndrome","volume":"11","author":"Dotta","year":"2011","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jpeds.2012.05.058_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng1149","article-title":"Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease","volume":"34","author":"Hernandez","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2012.05.058_bib5","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1182\/blood-2004-06-2289","article-title":"WHIM syndrome with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12","volume":"105","author":"Balabanian","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2012.05.058_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood-2007-07-102103","article-title":"CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome","volume":"112","author":"Lagane","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2012.05.058_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11882-005-0005-0","article-title":"WHIM syndrome: a defect in CXCR4 signaling","volume":"5","author":"Diaz","year":"2005","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jpeds.2012.05.058_bib8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1155\/2010\/475104","article-title":"CXCL12\/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome","volume":"29","author":"Bachelerie","year":"2010","journal-title":"Dis Markers"},{"key":"10.1016\/j.jpeds.2012.05.058_bib9","first-page":"408","article-title":"A chemokine, SDF-1\/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of haematopoiesis","volume":"72","author":"Nagasawa","year":"2000","journal-title":"Int J Haematol"},{"key":"10.1016\/j.jpeds.2012.05.058_bib10","doi-asserted-by":"crossref","first-page":"e15397","DOI":"10.1371\/journal.pone.0015397","article-title":"An essential role of the cytoplasmic tail of CXCR4 in G-protein signaling and organogenesis","volume":"5","author":"Cronshaw","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2012.05.058_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1182\/blood-2006-05-025296","article-title":"WHIM syndrome myelokathexis reproduced in the NOD\/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4","volume":"109","author":"Kawai","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2012.05.058_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/31269","article-title":"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development","volume":"393","author":"Zou","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2012.05.058_bib13","doi-asserted-by":"crossref","first-page":"14726","DOI":"10.1073\/pnas.93.25.14726","article-title":"Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor\/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin","volume":"93","author":"Nagasawa","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2012.05.058_bib14","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/S0140-6736(09)60657-7","article-title":"Tetralogy of Fallot","volume":"374","author":"Apitz","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2012.05.058_bib15","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s00268-009-0296-8","article-title":"Tetralogy of Fallot: yesterday and today","volume":"34","author":"Starr","year":"2010","journal-title":"World J Surg"},{"key":"10.1016\/j.jpeds.2012.05.058_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ahj.2010.09.015","article-title":"Patterns of cardiac and extracardiac anomalies in adults with tetralogy of Fallot","volume":"161","author":"Piran","year":"2011","journal-title":"Am Heart J"},{"key":"10.1016\/j.jpeds.2012.05.058_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1749-6632.2001.tb03933.x","article-title":"Role of chemokine SDF-1\/PBSF and its receptor CXCR4 in blood vessel development","volume":"947","author":"Nagasawa","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jpeds.2012.05.058_bib18","doi-asserted-by":"crossref","first-page":"35760","DOI":"10.1074\/jbc.M508234200","article-title":"The chemokine SDF-1\/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes","volume":"280","author":"Balabanian","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpeds.2012.05.058_bib19","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1084\/jem.20052144","article-title":"A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development","volume":"203","author":"Burns","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.jpeds.2012.05.058_bib20","doi-asserted-by":"crossref","first-page":"14759","DOI":"10.1073\/pnas.0702229104","article-title":"Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12\/SDF-1 receptor, CXCR7","volume":"104","author":"Sierro","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2012.05.058_bib21","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1582-4934.2011.01301.x","article-title":"The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells","volume":"15","author":"Dai","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jpeds.2012.05.058_bib22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/dvdy.22549","article-title":"The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling","volume":"240","author":"Yu","year":"2011","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jpeds.2012.05.058_bib23","doi-asserted-by":"crossref","first-page":"e9175","DOI":"10.1371\/journal.pone.0009175","article-title":"CXCR7 functions as a scavenger for CXCL12 and CXCL11","volume":"5","author":"Naumann","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2012.05.058_bib24","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1182\/blood-2008-12-196618","article-title":"CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling","volume":"113","author":"Levoye","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2012.05.058_bib25","doi-asserted-by":"crossref","first-page":"32188","DOI":"10.1074\/jbc.M111.277038","article-title":"CXCR7\/CXCR4 heterodimer constitutively recruits {beta}-arrestin to enhance cell migration","volume":"286","author":"Decaillot","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpeds.2012.05.058_bib26","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1182\/blood-2011-07-368084","article-title":"The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome","volume":"118","author":"McDermott","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2012.05.058_bib27","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1182\/blood-2011-06-360586","article-title":"The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome","volume":"118","author":"Dale","year":"2011","journal-title":"Blood"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347612006166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347612006166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T09:20:59Z","timestamp":1542878459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347612006166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0022347612006166"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2012.05.058","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}