{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:29:47Z","timestamp":1790101787584,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK082792A"],"award-info":[{"award-number":["K24DK082792A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.jpeds.2012.12.096","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T11:14:02Z","timestamp":1361186042000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children"],"prefix":"10.1016","volume":"163","author":[{"given":"Leonel","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2012.12.096_bib1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0016-5085(98)70012-5","article-title":"Role of impaired gastric accommodation to a meal in functional dyspepsia","volume":"115","author":"Tack","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib2","first-page":"157","article-title":"Impaired accommodation of the proximal stomach in children with recurrent abdominal pain","volume":"30","author":"Olafsdottir","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2012.12.096_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1053\/gast.2001.27180","article-title":"Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia","volume":"121","author":"Tack","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/gut.2005.089508","article-title":"Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction?","volume":"56","author":"Karamanolis","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jpeds.2012.12.096_bib5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/gut.2007.137125","article-title":"Relationship between symptoms and ingestion of a meal in functional dyspepsia","volume":"57","author":"Bisschops","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jpeds.2012.12.096_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2036.2003.01605.x","article-title":"Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans","volume":"18","author":"Lee","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2012.12.096_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-2999(97)01366-6","article-title":"Effects of ondansetron on electrically evoked contraction in rat stomach fundus: possible involvement of 5-HT2B receptors","volume":"339","author":"Amemiya","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.dld.2007.11.013","article-title":"Effect of the 5-HT3 receptor antagonist, ondansetron, on gastric size in dyspeptic patients with impaired gastric accommodation","volume":"40","author":"Marzio","year":"2008","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jpeds.2012.12.096_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-2036.2002.01152.x","article-title":"Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?","volume":"16","author":"Netzer","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2012.12.096_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2982.2010.01631.x","article-title":"Influence of ondansetron on gastric sensorimotor responses to short duodenal acid\u00a0infusion in healthy volunteers","volume":"23","author":"Vanuytsel","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2012.12.096_bib11","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1248\/bpb.30.508","article-title":"Pharmacological characterization of 5-hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach","volume":"30","author":"Komada","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jpeds.2012.12.096_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1254\/jjp.79.41","article-title":"Regional and functional differences of 5-hydroxytryptamine receptor subtypes in guinea pig stomach","volume":"79","author":"Takemura","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1474-8673.2006.00365.x","article-title":"Pharmacological characterization of 5-hydroxytryptamine\u2013induced contraction in the chicken gastrointestinal tract","volume":"26","author":"Kitazawa","year":"2006","journal-title":"Auton Autacoid Pharmacol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib14","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.bjp.0704376","article-title":"Characterization of the receptors involved in the 5-HT\u2013induced excitation of canine antral longitudinal muscle","volume":"134","author":"Prins","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jama.1962.03050240008002","article-title":"Effect of cyproheptadine on asthmatic children: study of appetite, weight gain, and linear growth","volume":"180","author":"Lavenstein","year":"1962","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2012.12.096_bib16","first-page":"270","article-title":"Appetite-stimulating properties of cyproheptadine","volume":"108","author":"Bergen","year":"1964","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpeds.2012.12.096_bib17","first-page":"1367","article-title":"Cyproheptadine for the treatment of functional abdominal pain in childhood: a double-blinded randomized placebo-controlled trial","volume":"60","author":"Sadeghian","year":"2008","journal-title":"Minerva Pediatr"},{"key":"10.1016\/j.jpeds.2012.12.096_bib18","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/j.gastro.2005.11.065","article-title":"Childhood functional gastrointestinal disorders: neonate\/toddler","volume":"130","author":"Hyman","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib19","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00006565-199910000-00006","article-title":"Cyproheptadine for serotonin syndrome in an accidental pediatric sertraline ingestion","volume":"15","author":"Horowitz","year":"1999","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jpeds.2012.12.096_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00005792-200007000-00001","article-title":"Serotonin syndrome: presentation of 2 cases and review of the literature","volume":"79","author":"Mason","year":"2000","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jpeds.2012.12.096_bib22","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/15563650801938654","article-title":"Serotonin syndrome following a single 50 mg dose of sertraline in a child","volume":"46","author":"Phan","year":"2008","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.jpeds.2012.12.096_bib23","first-page":"155","article-title":"5-Hydroxytryptamine (5-HT) and SK&F 103829 contract canine lower esophageal sphincter smooth muscle by stimulating 5-HT2 receptors","volume":"2","author":"Barnette","year":"1992","journal-title":"Receptor"},{"key":"10.1016\/j.jpeds.2012.12.096_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2011-000622","article-title":"Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with meta-analysis and mixed treatment comparison in a Bayesian framework","volume":"2","author":"Carter","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.jpeds.2012.12.096_bib25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1365-2982.2007.00988.x","article-title":"Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia: effect of the 5HT3-antagonist ondansetron","volume":"19","author":"Dizdar","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2012.12.096_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.clinthera.2012.01.007","article-title":"A network meta-analysis on the efficacy of serotonin type 3 receptor antagonists used in adults during the first 24 hours for postoperative nausea and vomiting prophylaxis","volume":"34","author":"Tang","year":"2012","journal-title":"Clin Ther"},{"key":"10.1016\/j.jpeds.2012.12.096_bib27","first-page":"1609","article-title":"Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study","volume":"19","author":"Boccia","year":"2011","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jpeds.2012.12.096_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02849860","article-title":"Effect of cyproheptadine on serum leptin levels","volume":"22","author":"Calka","year":"2005","journal-title":"Adv Ther"},{"key":"10.1016\/j.jpeds.2012.12.096_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pediatrneurol.2009.04.019","article-title":"Prophylactic drugs and cytokine and leptin levels in children with migraine","volume":"41","author":"Hirfanoglu","year":"2009","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1136\/gut.51.6.781","article-title":"SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication: single photon emission computed tomography","volume":"51","author":"Bouras","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jpeds.2012.12.096_bib31","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S1542-3565(03)00130-7","article-title":"Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms","volume":"1","author":"Bredenoord","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib32","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1007\/s10620-006-9632-0","article-title":"Drinking capacity and severity of dyspeptic symptoms during a water load test after Nissen fundoplication","volume":"52","author":"Remes-Troche","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jpeds.2012.12.096_bib33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1053\/j.gastro.2005.10.019","article-title":"Association of the predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia","volume":"130","author":"Karamanolis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib34","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1365-2982.2009.01374.x","article-title":"Relationship between symptom pattern, assessed by the PAGI-SYM questionnaire, and gastric sensorimotor dysfunction in functional dyspepsia","volume":"21","author":"Kindt","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2012.12.096_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2982.2006.00850.x","article-title":"Assessment of gastric sensorimotor function in paediatric patients with unexplained dyspeptic symptoms and poor weight gain","volume":"19","author":"Hoffman","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2012.12.096_bib36","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ajg.2010.58","article-title":"Differences in gastrointestinal symptoms according to gender in Rome II-positive IBS and dyspepsia in a Latin American population","volume":"105","author":"Schmulson","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 3","key":"10.1016\/j.jpeds.2012.12.096_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1440-1746.2011.06645.x","article-title":"Functional gastrointestinal disorders in New Zealand","volume":"26","author":"Wyeth","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/j.gastro.2010.10.015","article-title":"Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity","volume":"140","author":"Parkman","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2012.12.096_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1550-8579(06)80192-0","article-title":"Gender-related differences in dyspepsia: a qualitative systematic review","volume":"3","author":"Ahlawat","year":"2006","journal-title":"Gender Med"},{"key":"10.1016\/j.jpeds.2012.12.096_bib40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2982.2008.01241.x","article-title":"The placebo response in functional dyspepsia: reanalysis of trial data","volume":"21","author":"Enck","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2012.12.096_bib41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1365-2036.2006.02845.x","article-title":"Predictors of the placebo response in functional dyspepsia","volume":"23","author":"Talley","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2012.12.096_bib42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ppul.20265","article-title":"Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis","volume":"40","author":"Homnick","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpeds.2012.12.096_bib43","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/00004583-199806000-00018","article-title":"Case study: cyproheptadine and aggression in a five-year-old boy","volume":"37","author":"Strayhorn","year":"1998","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpeds.2012.12.096_bib44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1515\/JPEM.2009.22.5.459","article-title":"Childhood virilization and adrenal suppression after ingestion of methandienone and cyproheptadine","volume":"22","author":"Poomthavorn","year":"2009","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2012.12.096_bib45","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0022-3476(87)80310-4","article-title":"Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy","volume":"110","author":"Kaplowitz","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2012.12.096_bib46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0736-4679(85)90004-6","article-title":"Central anticholinergic syndrome in a child: a case report","volume":"3","author":"Richmond","year":"1985","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jpeds.2012.12.096_bib47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00006565-198609000-00009","article-title":"An unusual case of cyproheptadine (Periactin) overdose in an adolescent female","volume":"2","author":"Baehr","year":"1986","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jpeds.2012.12.096_bib48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00006565-199508000-00012","article-title":"Cyproheptadine-induced central anticholinergic syndrome in a child: a case report","volume":"11","author":"Blaustein","year":"1995","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jpeds.2012.12.096_bib49","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/15563650.2011.602085","article-title":"Review of the epidemiology and characteristics of intentional cyproheptadine overdose in Hong Kong","volume":"49","author":"Chu","year":"2011","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.jpeds.2012.12.096_bib50","first-page":"123","article-title":"Toxicity of cyproheptadine: side effects and accidental overdosage","volume":"126","author":"von Muhlendahl","year":"1978","journal-title":"Monatsschr Kinderheilkd"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347613000085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347613000085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:56:17Z","timestamp":1758358577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347613000085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0022347613000085"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2012.12.096","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and Efficacy of Cyproheptadine for Treating Dyspeptic Symptoms in Children","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2012.12.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}