{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:06:21Z","timestamp":1770440781115,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.jpeds.2013.11.065","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T20:16:07Z","timestamp":1389298567000},"page":"801-806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Skeletal Maturation in Children with Cushing Syndrome Is Not Consistently Delayed: The Role of Corticotropin, Obesity, and Steroid Hormones, and the Effect of Surgical Cure"],"prefix":"10.1016","volume":"164","author":[{"given":"Maya B.","family":"Lodish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Gourgari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninet","family":"Sinaii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvimol","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Libuit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Mastroyannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Keil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia L.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2013.11.065_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2265.2005.02244.x","article-title":"Final adult height and body mass index after cure of paediatric Cushing's disease","volume":"62","author":"Davies","year":"2005","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib2","first-page":"3262","article-title":"Linear growth and final height after treatment for Cushing's disease in childhood","volume":"85","author":"Lebrethon","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib3","first-page":"131","article-title":"Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure","volume":"78","author":"Magiakou","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib4","first-page":"207","article-title":"Growth retardation in Cushing's syndrome","volume":"123","author":"Strickland","year":"1972","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpeds.2013.11.065_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0303-7207(02)00276-9","article-title":"Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes","volume":"197","author":"Koedam","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib6","first-page":"15","article-title":"Androgens and the skeleton","volume":"30","author":"Lindberg","year":"2005","journal-title":"Minerva Endocrinol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib7","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1365-2265.2007.02822.x","article-title":"Abnormal puberty in paediatric Cushing's disease: relationship with adrenal androgen, sex hormone binding globulin and gonadotrophin concentrations","volume":"66","author":"Dupuis","year":"2007","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1056\/NEJM195604052541402","article-title":"Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children","volume":"254","author":"Blodgett","year":"1956","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2013.11.065_bib9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0889-8529(05)70348-0","article-title":"Growth suppression by glucocorticoid therapy","volume":"25","author":"Allen","year":"1996","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jpeds.2013.11.065_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1203\/00006450-197507000-00005","article-title":"Growth and skeletal maturation in asthmatic children: effect of corticosteroid treatment","volume":"9","author":"Morris","year":"1975","journal-title":"Pediatr Res"},{"issue":"Suppl 2","key":"10.1016\/j.jpeds.2013.11.065_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/rheumatology\/32.suppl_2.39","article-title":"Dose-dependent effects of deflazacort and prednisone on growth and skeletal maturation","volume":"32","author":"Aicardi","year":"1993","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF00856538","article-title":"Alternate-day steroids affect carpal maturation more than radius, ulna and short bones","volume":"8","author":"Polito","year":"1994","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jpeds.2013.11.065_bib13","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJM199409083311002","article-title":"Cushing's syndrome in children and adolescents: presentation, diagnosis, and therapy","volume":"331","author":"Magiakou","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2013.11.065_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11102-010-0246-3","article-title":"Bone age and factors affecting skeletal maturation at diagnosis of paediatric Cushing's disease","volume":"13","author":"Acharya","year":"2010","journal-title":"Pituitary"},{"key":"10.1016\/j.jpeds.2013.11.065_bib15","first-page":"231","article-title":"Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease","volume":"68","author":"Peters","year":"2007","journal-title":"Horm Res"},{"key":"10.1016\/j.jpeds.2013.11.065_bib16","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1542\/peds.2006-2402","article-title":"Diagnostic tests for children who are referred for the investigation of Cushing syndrome","volume":"120","author":"Batista","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2013.11.065_bib17","series-title":"Radiographic atlas of skeletal development of the hand and wrist","author":"Greulich","year":"1959"},{"key":"10.1016\/j.jpeds.2013.11.065_bib18","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1373\/clinchem.2010.143222","article-title":"Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervals","volume":"56","author":"Kushnir","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.jpeds.2013.11.065_bib19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1515\/cclm.2002.202","volume":"40","author":"Elmlinger","year":"2002","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jpeds.2013.11.065_bib20","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1210\/jcem.86.12.8117","article-title":"Reference values for IGF-I throughout childhood and adolescence: a model that accounts simultaneously for the effect of gender, age, and puberty","volume":"86","author":"Lofqvist","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00774-004-0544-9","article-title":"The relationships between pubertal development, IGF-1 axis, and bone formation in healthy adolescents","volume":"23","author":"Kanbur","year":"2005","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib22","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0140-6736(84)91873-7","article-title":"Dissociation between plasma adrenal androgens and cortisol in Cushing's disease and ectopic ACTH-producing tumour: relation to adrenarche","volume":"1","author":"Hauffa","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2013.11.065_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.clnu.2011.11.007","article-title":"Anthropometric measures and fasting insulin levels in children before and after cure of Cushing syndrome","volume":"31","author":"Keil","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jpeds.2013.11.065_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1067\/mpd.2001.119446","article-title":"The relation between skeletal maturation and adiposity in African American and Caucasian children","volume":"139","author":"Russell","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2013.11.065_bib25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ijo.2011.238","article-title":"Patterns of linear growth and skeletal maturation from birth to 18 years of age in overweight young adults","volume":"36","author":"Johnson","year":"2012","journal-title":"Int J Obes (Lond)"},{"issue":"Suppl 2","key":"10.1016\/j.jpeds.2013.11.065_bib26","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1515\/jpem-2001-s204","article-title":"Factors determining final height in congenital adrenal hyperplasia","volume":"14","author":"New","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib27","first-page":"1082","article-title":"Final stature in patients with endogenous Cushing's syndrome","volume":"79","author":"Magiakou","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2013.11.065_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1373\/clinchem.2003.023325","article-title":"Immunoassay of estradiol: unanticipated suppression by unconjugated estriol","volume":"50","author":"Cao","year":"2004","journal-title":"Clin Chem"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761301500X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761301500X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:56:07Z","timestamp":1758358567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234761301500X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S002234761301500X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2013.11.065","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal Maturation in Children with Cushing Syndrome Is Not Consistently Delayed: The Role of Corticotropin, Obesity, and Steroid Hormones, and the Effect of Surgical Cure","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2013.11.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Mosby, Inc.","name":"copyright","label":"Copyright"}]}}