{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:08:19Z","timestamp":1791101299813,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-NS042804"],"award-info":[{"award-number":["U01-NS042804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2 RR024983"],"award-info":[{"award-number":["KL2 RR024983"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jpeds.2014.01.001","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T12:02:49Z","timestamp":1392292969000},"page":"1175-1180.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Headache and Migraine in Children with Sickle Cell Disease Are Associated with Lower Hemoglobin and Higher Pain Event Rates But Not Silent Cerebral Infarction"],"prefix":"10.1016","volume":"164","author":[{"given":"Michael M.","family":"Dowling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Noetzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Rodeghier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah G.","family":"Hirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca N.","family":"Ichord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L.","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Steven","family":"Roach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenella J.","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Casella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"DeBaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2014.01.001_bib1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pediatrneurol.2005.10.017","article-title":"Trials in sickle cell disease","volume":"34","author":"Kirkham","year":"2006","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib2","first-page":"394","article-title":"Neurological complications of sickle cell anemia in Nigerian Africans: a case-control study","volume":"100","author":"Kehinde","year":"2008","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.jpeds.2014.01.001_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpeds.2007.02.015","article-title":"Headache in children with sickle cell disease: prevalence and associated factors","volume":"151","author":"Niebanck","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.001_bib4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/bmj.309.6957.765","article-title":"Prevalence of headache and migraine in schoolchildren","volume":"309","author":"Abu-Arefeh","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2014.01.001_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00043426-199611000-00017","article-title":"Skull infarction and epidural hematomas in a patient with sickle cell anemia","volume":"18","author":"Resar","year":"1996","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10245330601111912","article-title":"Skull bone infarctive crisis and deep vein thrombosis in homozygous sickle cell disease- case report and review of the literature","volume":"12","author":"Alli","year":"2007","journal-title":"Hematology"},{"key":"10.1016\/j.jpeds.2014.01.001_bib7","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1542\/peds.113.3.e265","article-title":"Pseudotumor cerebri in children with sickle cell disease: a case series","volume":"113","author":"Henry","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.01.001_bib8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0008-4182(05)80097-3","article-title":"Idiopathic intracranial hypertension and sickle cell disease: two case reports","volume":"40","author":"Segal","year":"2005","journal-title":"Can J Ophthalmol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11916-007-0224-2","article-title":"Medical causes of headache in children","volume":"11","author":"Abend","year":"2007","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.jpeds.2014.01.001_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1474-4422(04)00824-5","article-title":"Medication-overuse headache: a worldwide problem","volume":"3","author":"Diener","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0733-8619(03)00090-2","article-title":"Drug-induced headache","volume":"22","author":"Young","year":"2004","journal-title":"Neurol Clin"},{"key":"10.1016\/j.jpeds.2014.01.001_bib12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.mph.0000175408.27180.8e","article-title":"Headache symptoms in pediatric sickle cell patients","volume":"27","author":"Palermo","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1526-4610.1999.3907494.x","article-title":"Epidemiology of migraine among students from randomly selected secondary schools in Lodz","volume":"39","author":"Split","year":"1999","journal-title":"Headache"},{"key":"10.1016\/j.jpeds.2014.01.001_bib14","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.112.1.e1","article-title":"Quality of life in childhood migraines: clinical impact and comparison to other chronic illnesses","volume":"112","author":"Powers","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.01.001_bib15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0306-9877(96)90133-4","article-title":"Migraine and sickle-cell disorders: is there a cause for concern?","volume":"46","author":"Salman","year":"1996","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jpeds.2014.01.001_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for subclinical brain lesions","volume":"291","author":"Kruit","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2014.01.001_bib17","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/01.STR.28.6.1158","article-title":"Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults. The Cardiovascular Health Study","volume":"28","author":"Price","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2014.01.001_bib18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1474-4422(07)70170-9","article-title":"Silent brain infarcts: a systematic review","volume":"6","author":"Vermeer","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib19","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1001\/jama.2009.932","article-title":"Migraine headache in middle age and late-life brain infarcts","volume":"301","author":"Scher","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2014.01.001_bib20","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/archneur.61.9.1366","article-title":"Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis","volume":"61","author":"Swartz","year":"2004","journal-title":"Arch Neurol"},{"issue":"Suppl A100","key":"10.1016\/j.jpeds.2014.01.001_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1747-4949.2012.00925.x","article-title":"International Paediatric Stroke Study: stroke associated with cardiac disorders","volume":"8","author":"Dowling","year":"2013","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jpeds.2014.01.001_bib22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1468-2982.2006.01092.x","article-title":"Migraine-mimicking headache and sickle cell disease: a transcranial Doppler study","volume":"26","author":"Silva","year":"2006","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpeds.2014.01.001_bib23","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1177\/0883073811405054","article-title":"Laboratory and clinical correlates for magnetic resonance imaging (MRI) abnormalities in pediatric sickle cell anemia","volume":"26","author":"Lebensburger","year":"2011","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1365-2141.2009.07753.x","article-title":"Silent infarcts in young children with sickle cell disease","volume":"146","author":"Kwiatkowski","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib25","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2014.01.001_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/08880010903360367","article-title":"Design of the silent cerebral infarct transfusion (SIT) trial","volume":"27","author":"Casella","year":"2010","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib27","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2011-05-349621","article-title":"Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2014.01.001_bib28","first-page":"9","article-title":"The International Classification of Headache Disorders, 2nd edition","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpeds.2014.01.001_bib29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1468-2982.2000.00103.x","article-title":"Migraine without aura and migrainous disorder in children; International Headache Society (IHS) and revised IHS criteria","volume":"20","author":"Cano","year":"2000","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpeds.2014.01.001_bib30","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1468-2982.2005.00954.x","article-title":"Critical analysis of the International Classification of Headache Disorders diagnostic criteria (ICHD I-1988) and (ICHD II-2004), for migraine in children and adolescents","volume":"25","author":"Lima","year":"2005","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jpeds.2014.01.001_bib31","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1526-4610.2005.00260.x","article-title":"Use of the ICHD-II criteria in the diagnosis of pediatric migraine","volume":"45","author":"Hershey","year":"2005","journal-title":"Headache"},{"key":"10.1016\/j.jpeds.2014.01.001_bib32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1474-4422(10)70005-3","article-title":"Current practice and future directions in the prevention and acute management of migraine","volume":"9","author":"Goadsby","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1055\/s-0030-1249224","article-title":"Diagnosis and management of chronic daily headache","volume":"30","author":"Garza","year":"2010","journal-title":"Semin Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0065-3101(24)00141-5","article-title":"Neurologic complications of sickle cell disease","volume":"36","author":"Pavlakis","year":"1989","journal-title":"Adv Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.001_bib35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jpeds.2011.02.009","article-title":"Central nervous system events in children with sickle cell disease presenting acutely with headache","volume":"159","author":"Hines","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.001_bib36","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1212\/WNL.59.4.490","article-title":"Practice parameter: evaluation of children and adolescents with recurrent headaches. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society","volume":"59","author":"Lewis","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2014.01.001_bib37","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.hoc.2004.07.004","article-title":"Risk factors and prediction of outcomes in children and adolescents who have sickle cell anemia","volume":"18","author":"Quinn","year":"2004","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.jpeds.2014.01.001_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.wco.0000169750.52406.a2","article-title":"Comorbidity of migraine","volume":"18","author":"Scher","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.jpeds.2014.01.001_bib39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/01.wnl.0000193630.03650.19","article-title":"Analgesic overuse among adolescents with headache: the Head-HUNT-Youth Study","volume":"66","author":"Dyb","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2014.01.001_bib40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2141.2009.07652.x","article-title":"Haemoglobin oxygen saturation is a determinant of cerebral artery blood flow velocity in children with sickle cell anaemia","volume":"145","author":"Quinn","year":"2009","journal-title":"Br J Haematol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761400002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761400002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:20:08Z","timestamp":1777432808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234761400002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S002234761400002X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.01.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718278433.793491766","asserted-by":"object"}]},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Headache and Migraine in Children with Sickle Cell Disease Are Associated with Lower Hemoglobin and Higher Pain Event Rates But Not Silent Cerebral Infarction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}