{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:27Z","timestamp":1786993227804,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jpeds.2014.01.028","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T12:15:21Z","timestamp":1393330521000},"page":"999-1004.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1016","volume":"164","author":[{"given":"Ori","family":"Hochwald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jabr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Osiovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal M.","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2014.01.028_bib1","first-page":"409","article-title":"No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths","volume":"83","author":"Lawn","year":"2005","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jpeds.2014.01.028_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00431-007-0437-8","article-title":"Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review","volume":"166","author":"van Handel","year":"2007","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib3","doi-asserted-by":"crossref","first-page":"F454","DOI":"10.1136\/adc.2005.092445","article-title":"Does perinatal asphyxia impair cognitive function without cerebral palsy?","volume":"91","author":"Gonzalez","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2014.01.028_bib4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/adc.2011.214205","article-title":"Cardiovascular dysfunction in infants with neonatal encephalopathy","volume":"97","author":"Armstrong","year":"2012","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2014.01.028_bib5","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2014.01.028_bib6","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpeds.2014.01.028_bib7","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1136\/adc.2005.071787","article-title":"Therapeutic hypothermia following perinatal asphyxia","volume":"91","author":"Edwards","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"Pt\u00a01","key":"10.1016\/j.jpeds.2014.01.028_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(05)72459-8","article-title":"Vasoparalysis associated with brain damage in asphyxiated term infants","volume":"117","author":"Pryds","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.braindev.2008.06.003","article-title":"Changes in\u00a0cerebral hemodynamics and amplitude integrated EEG in an asphyxiated newborn during and after cool cap treatment","volume":"31","author":"Ancora","year":"2009","journal-title":"Brain Dev"},{"key":"10.1016\/j.jpeds.2014.01.028_bib10","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1542\/peds.2004-1587","article-title":"Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming","volume":"117","author":"Gebauer","year":"2006","journal-title":"Pediatrics"},{"issue":"Pt 1","key":"10.1016\/j.jpeds.2014.01.028_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1542\/peds.106.1.92","article-title":"Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy","volume":"106","author":"Thoresen","year":"2000","journal-title":"Pediatrics"},{"issue":"Suppl","key":"10.1016\/j.jpeds.2014.01.028_bib12","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.jpeds.2010.11.007","article-title":"Functional echocardiography in assessment of the cardiovascular system in asphyxiated neonates","volume":"158","author":"Kluckow","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib13","doi-asserted-by":"crossref","first-page":"F182","DOI":"10.1136\/fn.82.3.F182","article-title":"Superior vena cava flow in newborn infants: a novel marker of systemic blood flow","volume":"82","author":"Kluckow","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2014.01.028_bib14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress.\u00a0A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jpeds.2014.01.028_bib15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2014.01.028_bib16","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.echo.2006.06.006","article-title":"Left ventricular Tei index in children: comparison of tissue Doppler imaging, pulsed wave Doppler, and M-mode echocardiography normal values","volume":"19","author":"Cui","year":"2006","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib17","first-page":"135","article-title":"New non-invasive index for combined systolic and diastolic ventricular function","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"},{"key":"10.1016\/j.jpeds.2014.01.028_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ejechocard\/jer181","article-title":"Targeted neonatal echocardiography in the neonatal intensive care unit: practice guidelines and recommendations for training","volume":"12","author":"Mertens","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1542\/peds.2008-0283","article-title":"Comparison of computer tomography and magnetic resonance imaging scans on the third day of life in term newborns with neonatal encephalopathy","volume":"123","author":"Chau","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.01.028_bib20","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1553-2712.1999.tb00114.x","article-title":"A prospective evaluation of the electrocardiographic manifestations of hypothermia","volume":"6","author":"Vassallo","year":"1999","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jpeds.2014.01.028_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2014.01.028_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jpeds.2005.06.033","article-title":"Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome","volume":"147","author":"Miller","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.01.028_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.earlhumdev.2012.10.011","article-title":"Correlation between echocardiographic superior vena cava flow and short-term outcome in infants with asphyxia","volume":"89","author":"Kumagai","year":"2013","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2014.01.028_bib24","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3174\/ajnr.A2708","article-title":"Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia","volume":"32","author":"Wintermark","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2014.01.028_bib25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1212\/WNL.49.4.1035","article-title":"Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome","volume":"49","author":"Rosenbaum","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2014.01.028_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/jcbfm.2011.164","article-title":"Mild hypoxemia during initial reperfusion alleviates the severity of secondary energy failure and protects brain in neonatal mice with hypoxic-ischemic injury","volume":"32","author":"Niatsetskaya","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jpeds.2014.01.028_bib27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.braindev.2012.10.007","article-title":"Cerebral blood volume combined with amplitude-integrated EEG can be a suitable guide to control hypoxic\/ischemic insult in a piglet model","volume":"35","author":"Nakamura","year":"2013","journal-title":"Brain Dev"},{"key":"10.1016\/j.jpeds.2014.01.028_bib28","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2014.01.028_bib29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347614000560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347614000560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:56:04Z","timestamp":1758358564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347614000560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0022347614000560"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.01.028","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}