{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:23:54Z","timestamp":1792797834122,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jpeds.2014.08.041","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:07:40Z","timestamp":1411690060000},"page":"1154-1160.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns"],"prefix":"10.1016","volume":"165","author":[{"given":"Youyou","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2014.08.041_bib1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/archpedi.1990.02150270114039","article-title":"Laboratory evaluation of jaundice in newborns: frequency, cost, and yield","volume":"144","author":"Newman","year":"1990","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpeds.2014.08.041_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1542\/peds.94.4.558","article-title":"Practice parameter: management of hyperbilirubinemia in the healthy term newborn","volume":"94","author":"American Academy of Pediatrics, Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib3","doi-asserted-by":"crossref","first-page":"e864","DOI":"10.1542\/peds.2007-1214","article-title":"Readmission for neonatal jaundice in California, 1991-2000: trends and implications","volume":"121","author":"Burgos","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-3476(98)70356-7","article-title":"Gilbert syndrome accelerates development of neonatal jaundice","volume":"132","author":"Bancroft","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.08.041_bib5","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1542\/peds.103.6.1224","article-title":"Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism","volume":"103","author":"Maruo","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib6","doi-asserted-by":"crossref","first-page":"e868","DOI":"10.1542\/peds.2009-0460","article-title":"Complex multifactorial nature of significant hyperbilirubinemia in neonates","volume":"124","author":"Watchko","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000209851","article-title":"UGT1A1 haplotype mutation among Asians in Singapore","volume":"96","author":"Zhou","year":"2009","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2014.08.041_bib8","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrg2670","article-title":"Common disorders are quantitative traits","volume":"10","author":"Plomin","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics, Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib10","series-title":"Practical neonatology","year":"1997"},{"key":"10.1016\/j.jpeds.2014.08.041_bib11","series-title":"Practical pediatrics","year":"1996"},{"key":"10.1016\/j.jpeds.2014.08.041_bib12","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(95)90702-5","article-title":"Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome","volume":"345","author":"Aono","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2014.08.041_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1086\/302729","article-title":"Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema","volume":"66","author":"Yamada","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/FPC.0b013e328328f818","article-title":"Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population","volume":"19","author":"Lin","year":"2009","journal-title":"Pharmacogenet Genom"},{"key":"10.1016\/j.jpeds.2014.08.041_bib16","doi-asserted-by":"crossref","first-page":"e104251","DOI":"10.1371\/journal.pone.0104251","article-title":"Association of UGT1A1 variants and hyperbilirubinemia in breast-fed full-term Chinese infants","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2014.08.041_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2307\/2532296","article-title":"Performing the exact test of Hardy-Weinberg proportion for multiple alleles","volume":"48","author":"Guo","year":"1992","journal-title":"Biometrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B"},{"key":"10.1016\/j.jpeds.2014.08.041_bib19","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","article-title":"Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism","volume":"95","author":"Beutler","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2014.08.041_bib20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/humu.20895","article-title":"Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations","volume":"30","author":"Lin","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jpeds.2014.08.041_bib21","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1542\/peds.2005-0744","article-title":"Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation","volume":"117","author":"Maisels","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib22","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1542\/peds.2009-0403","article-title":"Transcutaneous bilirubin levels for the first 120 postnatal hours in healthy neonates","volume":"125","author":"Fouzas","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2014.08.041_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00431-010-1281-9","article-title":"Transcutaneous bilirubin nomogram for predicting neonatal hyperbilirubinemia in healthy term and late-preterm Chinese infants","volume":"170","author":"Yu","year":"2011","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2014.08.041_bib24","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1006\/bbrc.1993.2610","article-title":"Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II","volume":"197","author":"Aono","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jpeds.2014.08.041_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1203\/PDR.0b013e31820263d2","article-title":"211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice","volume":"69","author":"Chou","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2014.08.041_bib26","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jpeds.2012.11.042","article-title":"UGT1A1 genetic analysis as a diagnostic aid for individuals with unconjugated hyperbilirubinemia","volume":"162","author":"Skierka","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2014.08.041_bib27","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1093\/hmg\/ddp202","article-title":"Genome-wide association meta-analysis for total serum bilirubin levels","volume":"18","author":"Johnson","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib28","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/hmg\/ddp203","article-title":"Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia","volume":"18","author":"Sanna","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib29","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1093\/hmg\/ddq281","article-title":"Genome-wide association of serum bilirubin levels in a Korean population","volume":"19","author":"Kang","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib30","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ejhg.2011.206","article-title":"UGT1A1 is a major locus influencing bilirubin levels in African Americans","volume":"20","author":"Chen","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.clpt.2004.01.010","article-title":"UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer","volume":"75","author":"Sai","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2014.08.041_bib32","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1469-1809.2010.00638.x","article-title":"Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations","volume":"75","author":"Horsfall","year":"2011","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.jpeds.2014.08.041_bib33","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1373\/clinchem.2003.024174","article-title":"Haplotype structure of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and its relationship to serum total bilirubin concentration in a male Korean population","volume":"49","author":"Ki","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.jpeds.2014.08.041_bib34","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/CIRCULATIONAHA.106.633206","article-title":"Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study","volume":"114","author":"Lin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2014.08.041_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/bj1960257","article-title":"The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver","volume":"196","author":"Kawade","year":"1981","journal-title":"Biochem J"},{"key":"10.1016\/j.jpeds.2014.08.041_bib36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0026-895X(25)10133-8","article-title":"The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes","volume":"34","author":"Coughtrie","year":"1988","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jpeds.2014.08.041_bib37","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1073\/pnas.0913290107","article-title":"Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus","volume":"107","author":"Fujiwara","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpeds.2014.08.041_bib38","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1651-2227.2009.01678.x","article-title":"Prolonged unconjugated hyperbilirubinaemia associated with the haem oxygenase-1 gene promoter polymorphism","volume":"99","author":"Bozkaya","year":"2010","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2014.08.041_bib39","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1542\/peds.2005-0590","article-title":"Bilirubin measurement for neonates: comparison of 9 frequently used methods","volume":"117","author":"Grohmann","year":"2006","journal-title":"Pediatrics"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347614007884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347614007884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:57:25Z","timestamp":1758358645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347614007884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0022347614007884"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.08.041","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2014.08.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}