{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:08:54Z","timestamp":1760249334105,"version":"3.40.5"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.jpeds.2015.04.005","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T19:56:25Z","timestamp":1430596585000},"page":"103-107.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Implications of a Multivariate Stratification Model for the Estimation of Prognosis in Ventricular Septal Defect"],"prefix":"10.1016","volume":"167","author":[{"given":"David A.","family":"Danford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameeta B.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Danford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-0979","authenticated-orcid":false,"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2015.04.005_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jtcvs.2012.11.032","article-title":"Contemporary outcomes of surgical ventricular septal defect closure","volume":"145","author":"Anderson","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpeds.2015.04.005_bib2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2010.03.085","article-title":"Changing mortality in congenital heart disease","volume":"56","author":"Khairy","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib3","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(87)91685-0","article-title":"Qualms about QALYs","volume":"1","author":"Smith","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2015.04.005_bib4","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1001\/jama.2011.566","article-title":"What next for QALYs?","volume":"305","author":"Neumann","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2015.04.005_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCOUTCOMES.108.812321","article-title":"The limits of cost-effectiveness analysis","volume":"2","author":"Weintraub","year":"2009","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jpeds.2015.04.005_bib6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00246-009-9496-0","volume":"30","author":"Jacobs","year":"2009","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jtcvs.2009.03.071","article-title":"An empirically based tool for analyzing mortality associated with congenital heart disease","volume":"138","author":"O\u2019Brien","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpeds.2015.04.005_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jtcvs.2008.11.073","article-title":"Lesion-specific outcomes in neonates undergoing congenital heart surgery are related predominantly to patient and management factors rather than institution or surgeon experience: a Congenital Heart Surgeons Society Study","volume":"139","author":"Karamlou","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpeds.2015.04.005_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1058-9813(01)00126-6","article-title":"Natural history and decision-making in patients with ventricular septal defect","volume":"14","author":"Gersony","year":"2001","journal-title":"Prog Pediatr Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib10","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/0002-8703(95)90147-7","article-title":"Quantitation of echocardiographic predictors of outcome in infants with isolated ventricular septal defect","volume":"130","author":"Shirali","year":"1995","journal-title":"Am Heart J"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2015.04.005_bib11","first-page":"I56","article-title":"Clinical course in ventricular septal defect","volume":"56","author":"Weidman","year":"1977","journal-title":"Circulation"},{"issue":"Suppl 2","key":"10.1016\/j.jpeds.2015.04.005_bib12","first-page":"I38","article-title":"Second natural history study of congenital heart defects. Results of treatment of patients with ventricular septal defects","volume":"87","author":"Kidd","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2015.04.005_bib13","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/0002-8703(84)90759-2","article-title":"Natural history of subarterial infundibular ventricular septal defect","volume":"108","author":"Momma","year":"1984","journal-title":"Am Heart J"},{"key":"10.1016\/j.jpeds.2015.04.005_bib14","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1161\/01.CIR.55.6.908","article-title":"Natural history of ventricular septal defect","volume":"55","author":"Corone","year":"1977","journal-title":"Circulation"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2015.04.005_bib15","first-page":"I78","article-title":"Clinical course in adults with ventricular septal defect","volume":"56","author":"Weidman","year":"1977","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2015.04.005_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002469900291","article-title":"The natural course of isolated ventricular septal defect during adolescence","volume":"19","author":"Onat","year":"1998","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/01.CIR.38.1.129","article-title":"Prognosis for patients with ventricular septal defect and severe pulmonary vascular obstructive disease","volume":"38","author":"Clarkson","year":"1968","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2015.04.005_bib18","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/hrt.59.4.480","article-title":"Correlations of lung morphology, pulmonary vascular resistance, and outcome in children with congenital heart disease","volume":"59","author":"Bush","year":"1988","journal-title":"Br Heart J"},{"key":"10.1016\/j.jpeds.2015.04.005_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/path.1711520304","article-title":"Pulmonary vascular disease in ventricular septal defect: structural and functional correlations in lung biopsies from 85 patients, with outcome of intracardiac repair","volume":"152","author":"Haworth","year":"1987","journal-title":"J Pathol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1136\/bmj.2.5099.755","article-title":"The Eisenmenger syndrome","volume":"2","author":"Wood","year":"1958","journal-title":"Br Med J"},{"key":"10.1016\/j.jpeds.2015.04.005_bib21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0002-9149(88)91079-X","article-title":"The association of ventricular septal defect and anomalous right ventricular muscle bundles with fixed subaortic stenosis: an echocardiographic study of 36 patients","volume":"61","author":"Vogel","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/0002-9149(83)90583-0","article-title":"Ventricular septal defect and subaortic stenosis: an analysis of 41 patients","volume":"52","author":"Vogel","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0002-9149(69)90411-1","article-title":"Concomitant development of infundibular pulmonary stenosis and spontaneous closure of ventricular septal defect. An unusual variant in the natural history of ventricular septal defect","volume":"24","author":"Jain","year":"1969","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-5223(19)41314-7","article-title":"Ventricular septal defect associated with left ventricular outflow obstruction below the defect","volume":"75","author":"Dirksen","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpeds.2015.04.005_bib25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/0735-1097(94)90120-1","article-title":"Long-term follow-up after surgical closure of ventricular septal defect in infancy and childhood","volume":"24","author":"Meijboom","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib26","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0002-9149(91)90284-R","article-title":"Late results (30 to 35 years) after operative closure of isolated ventricular septal defect from 1954 to 1960","volume":"68","author":"Moller","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/hrt.47.4.305","article-title":"Conduction defects, ventricular arrhythmias, and late death after surgical closure of ventricular septal defect","volume":"47","author":"Blake","year":"1982","journal-title":"Br Heart J"},{"key":"10.1016\/j.jpeds.2015.04.005_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0735-1097(98)00187-9","article-title":"A population-based prospective evaluation of risk of sudden cardiac death after operation for common congenital heart defects","volume":"32","author":"Silka","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib29","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0022-3476(78)81268-2","article-title":"Apparent sex difference in spontaneous closure of ventricular septal defect","volume":"93","author":"Farina","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.04.005_bib30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0022-3476(79)80694-0","article-title":"Sex difference in rates of spontaneous closure in ventricular septal defect","volume":"95","author":"Cook","year":"1979","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.04.005_bib31","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1161\/CIRCULATIONAHA.106.618124","article-title":"Ventricular septal defects","volume":"114","author":"Minette","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2015.04.005_bib32","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0197-2456(03)00072-2","article-title":"On the use and utility of the Weibull model in the analysis of survival data","volume":"24","author":"Carroll","year":"2003","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jpeds.2015.04.005_bib33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/EDE.0b013e3181c30fb2","article-title":"Assessing the performance of prediction models. A framework for traditional and novel measures","volume":"21","author":"Steyerberg","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.jpeds.2015.04.005_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002469900502","article-title":"Congenital heart disease among 815,569 children born between 1980 and 1990 and their 15-year survival: a prospective Bohemia survival study","volume":"20","author":"Samanek","year":"1999","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jpeds.2015.04.005_bib35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1017\/S1047951100007174","article-title":"Spontaneous closure of muscular ventricular septal defect identified by echocardiography in neonates","volume":"8","author":"Du","year":"1998","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jpeds.2015.04.005_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/hrt.73.1.49","article-title":"Haemodynamic, and clinical variables as predictors for management of isolated ventricular septal defect","volume":"73","author":"van den Heuval","year":"1995","journal-title":"Br Heart J"},{"key":"10.1016\/j.jpeds.2015.04.005_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1058-9813(01)00128-X","article-title":"Large ventricular septal defects in infants","volume":"14","author":"Talner","year":"2001","journal-title":"Prog Pediatr Cardiol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615003662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615003662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T18:50:12Z","timestamp":1598986212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347615003662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0022347615003662"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.04.005","relation":{},"ISSN":["0022-3476"],"issn-type":[{"type":"print","value":"0022-3476"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Implications of a Multivariate Stratification Model for the Estimation of Prognosis in Ventricular Septal Defect","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}