{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:57:58Z","timestamp":1778511478311,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007172","name":"Cincinnati Children&apos;s Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008728","name":"Japan Research Foundation for Clinical Pharmacology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HD069054"],"award-info":[{"award-number":["5T32HD069054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jpeds.2015.08.032","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T11:55:35Z","timestamp":1442058935000},"page":"1214-1220.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study"],"prefix":"10.1016","volume":"167","author":[{"given":"Jason R.","family":"Wiles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Isemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith E.","family":"Tabangin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura P.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Akinbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Vinks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2015.08.032_bib1","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.08.032_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.pcl.2012.07.006","article-title":"Pharmacologic management of the opioid neonatal abstinence syndrome","volume":"59","author":"Kraft","year":"2012","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jpeds.2015.08.032_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jpeds.2014.05.010","article-title":"Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure","volume":"165","author":"Wiles","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.08.032_bib4","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1001\/jama.2012.4526","article-title":"Epidemic of prescription opiate abuse and neonatal abstinence","volume":"307","author":"Hayes","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2015.08.032_bib5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/pds.1626","article-title":"Recent changes in drug poisoning mortality in the United States by urban-rural status and by drug type","volume":"17","author":"Paulozzi","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jpeds.2015.08.032_bib6","doi-asserted-by":"crossref","first-page":"259.e1","DOI":"10.1016\/j.ajog.2010.12.050","article-title":"Current trends in narcotic use in pregnancy and neonatal outcomes","volume":"204","author":"Kellogg","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib7","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009","volume":"307","author":"Patrick","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2015.08.032_bib8","first-page":"563","article-title":"Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines\u2014United States, 2012","volume":"63","author":"Paulozzi","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jpeds.2015.08.032_bib9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.annepidem.2013.05.017","article-title":"Increasing pregnancy-related use of prescribed opioid analgesics","volume":"23","author":"Epstein","year":"2013","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib10","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1542\/peds.2014-3299","article-title":"Prescription opioid epidemic and infant outcomes","volume":"135","author":"Patrick","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.08.032_bib11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jp.2015.36","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012","volume":"35","author":"Patrick","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib12","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1056\/NEJMoa1005359","article-title":"Neonatal abstinence syndrome after methadone or buprenorphine exposure","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2015.08.032_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5055\/jom.2009.0006","article-title":"The opioid exposed newborn: assessment and pharmacologic management","volume":"5","author":"Jansson","year":"2009","journal-title":"J Opioid Manag"},{"key":"10.1016\/j.jpeds.2015.08.032_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.clp.2013.05.004","article-title":"Management of neonatal abstinence syndrome from opioids","volume":"40","author":"Grim","year":"2013","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.jp.7211427","article-title":"Management of neonatal abstinence syndrome in neonatal intensive care units: a national survey","volume":"26","author":"Sarkar","year":"2006","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib16","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1542\/peds.2013-4036","article-title":"A Multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome","volume":"134","author":"Hall","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.08.032_bib17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/jp.2014.114","article-title":"Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004-2011","volume":"34","author":"Patrick","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/jp.2014.194","article-title":"Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial","volume":"35","author":"Brown","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpeds.2012.08.034","article-title":"Federal legislation and the advancement of neonatal drug studies","volume":"162","author":"Wiles","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.08.032_bib20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1365-2125.2004.02079.x","article-title":"Population pharmacokinetics of (R)-, (S)-, and rac-methadone in methadone maintenance patients","volume":"57","author":"Foster","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/pan.12021","article-title":"The pharmacokinetics of methadone in adolescents\u00a0undergoing posterior spinal fusion","volume":"23","author":"Stemland","year":"2013","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.jpeds.2015.08.032_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/pan.12385","article-title":"The pharmacokinetics of methadone and its metabolites in neonates, infants, and children","volume":"24","author":"Ward","year":"2014","journal-title":"Pediatr Anesth"},{"key":"10.1016\/j.jpeds.2015.08.032_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/ANC.0b013e318241bd73","article-title":"Implementing practice guidelines and education to improve care of infants with neonatal abstinence syndrome","volume":"12","author":"Lucas","year":"2012","journal-title":"Adv Neonatal Care"},{"key":"10.1016\/j.jpeds.2015.08.032_bib24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00216-011-4775-z","article-title":"A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry","volume":"400","author":"Clavijo","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jpeds.2015.08.032_bib25","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1002\/jssc.201100422","article-title":"A low blood volume LC-MS\/MS assay for the quantification\u00a0of fentanyl and its major metabolites norfentanyl and despropionyl\u00a0fentanyl in children","volume":"34","author":"Clavijo","year":"2011","journal-title":"J Sep Sci"},{"key":"10.1016\/j.jpeds.2015.08.032_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpba.2013.04.007","article-title":"Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry","volume":"83","author":"Taylor","year":"2013","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.jpeds.2015.08.032_bib27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1399-6576.2008.01597.x","article-title":"Clinical pharmacology\u00a0of methadone for pain","volume":"52","author":"Fredheim","year":"2008","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jpeds.2015.08.032_bib28","first-page":"485","article-title":"Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model","volume":"33","author":"Yang","year":"2006","journal-title":"J Pharmacokinet\u00a0Pharmacodyn"},{"key":"10.1016\/j.jpeds.2015.08.032_bib29","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1177\/0091270011422812","article-title":"Clarification on precision criteria to derive sample size when designing pediatric pharmacokinetic studies","volume":"52","author":"Wang","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib30","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1038\/psp.2012.4","article-title":"Basic concepts in population modeling, simulation and model-based drug development","volume":"1","author":"Mould","year":"2012","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1365-2125.1999.00974.x","article-title":"Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes","volume":"48","author":"Rostami-Hodjegan","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1177\/0091270009356572","article-title":"Practical, individualized dosing: 21st century therapeutics and the clinical pharmacometrician","volume":"50","author":"Neely","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2133\/dmpk.24.25","article-title":"Mechanistic basis of using body size and maturation to predict clearance in humans","volume":"24","author":"Anderson","year":"2009","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1016\/j.jpeds.2015.08.032_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/j.1552-4604.1997.tb04326.x","article-title":"Stability and performance of a population pharmacokinetic model","volume":"37","author":"Ette","year":"1997","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jpeds.2015.08.032_bib36","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1038\/psp.2013.24","article-title":"Modeling and simulation workbench for NONMEM: tutorial on Pirana, PsN and Xpose","volume":"2","author":"Keizer","year":"2013","journal-title":"CPT Pharmacometrics Syst Pharmacol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615008951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615008951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:57:43Z","timestamp":1758358663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347615008951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0022347615008951"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.08.032","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.09.047","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}