{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:13:55Z","timestamp":1790702035679,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Wilhelmina Children's Hospital Research Fund","award":["10-427"],"award-info":[{"award-number":["10-427"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jpeds.2015.09.083","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T02:41:07Z","timestamp":1446604867000},"page":"41-49.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Effects of Posthemorrhagic Ventricular Dilatation in the Preterm Infant\u00a0on\u00a0Brain Volumes and White Matter Diffusion Variables at\u00a0Term-Equivalent Age"],"prefix":"10.1016","volume":"168","author":[{"given":"Margaretha J.","family":"Brouwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina J.","family":"Kersbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas E.","family":"van der Aa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-8255","authenticated-orcid":false,"given":"Annemieke J.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A.","family":"Viergever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"I\u0161gum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo S.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon J.N.L.","family":"Benders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2015.09.083_bib1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/0883073809338067","article-title":"Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important","volume":"24","author":"Volpe","year":"2009","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.clp.2009.07.014","article-title":"Intracranial hemorrhage in the preterm infant: understanding it, preventing it","volume":"36","author":"Bassan","year":"2009","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00334666","article-title":"Neuropathological changes caused by hydrocephalus","volume":"85","author":"Del Bigio","year":"1993","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1651-2227.2012.02686.x","article-title":"Impaired brain growth and neurodevelopment in preterm infants with posthaemorrhagic ventricular dilatation","volume":"101","author":"Jary","year":"2012","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ejpn.2007.11.003","article-title":"Preterm birth and disruptive cerebellar development: assessment of perinatal risk factors","volume":"12","author":"Messerschmidt","year":"2008","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jpeds.2010.09.005","article-title":"Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth","volume":"158","author":"Tam","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib8","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1542\/peds.2004-0500","article-title":"Uncomplicated intraventricular hemorrhage is followed by reduced cortical volume at near-term age","volume":"114","author":"Vasileiadis","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.09.083_bib9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jpeds.2013.04.001","article-title":"Hydrocortisone treatment for bronchopulmonary dysplasia and brain volumes in preterm infants","volume":"163","author":"Kersbergen","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00234-015-1487-7","article-title":"Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging","volume":"57","author":"Morita","year":"2015","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jpeds.2015.09.083_bib11","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.3174\/ajnr.A3988","article-title":"Impaired white matter development in extremely low-birth-weight infants with previous brain hemorrhage","volume":"35","author":"Ou","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1203\/PDR.0b013e3181a1fb3d","article-title":"Cerebellar development in the preterm neonate: effect of supratentorial brain injury","volume":"66","author":"Tam","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib14","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/adc.56.12.900","article-title":"Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound","volume":"56","author":"Levene","year":"1981","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2015.09.083_bib15","doi-asserted-by":"crossref","first-page":"F218","DOI":"10.1136\/fn.82.3.F218","article-title":"Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates","volume":"82","author":"Davies","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2015.09.083_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(05)80189-5","article-title":"The spectrum of leukomalacia using cranial ultrasound","volume":"49","author":"de Vries","year":"1992","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.earlhumdev.2009.09.008","article-title":"New Dutch reference curves for birthweight by gestational age","volume":"85","author":"Visser","year":"2009","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2015.09.083_bib18","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2015.09.083_bib19","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.3174\/ajnr.A3521","article-title":"New MR imaging assessment tool to define brain abnormalities in very preterm infants at term","volume":"34","author":"Kidokoro","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1203\/PDR.0b013e31815ed071","article-title":"Probabilistic brain tissue segmentation in neonatal magnetic resonance imaging","volume":"63","author":"Anbeek","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib21","doi-asserted-by":"crossref","first-page":"e89061","DOI":"10.1371\/journal.pone.0089061","article-title":"Unmyelinated white matter loss in the preterm brain is associated with early increased levels of end-tidal carbon monoxide","volume":"9","author":"Blok","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2015.09.083_bib22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1469-8749.2011.04168.x","article-title":"Cerebellar volume and proton magnetic resonance spectroscopy at term, and neurodevelopment at 2 years of age in preterm infants","volume":"54","author":"Van Kooij","year":"2012","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib23","doi-asserted-by":"crossref","first-page":"e109556","DOI":"10.1371\/journal.pone.0109556","article-title":"Sequential cranial ultrasound and cerebellar diffusion weighted imaging contribute to the early prognosis of neurodevelopmental outcome in preterm infants","volume":"9","author":"Brouwer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2015.09.083_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ana.21171","article-title":"Early growth in brain volume is preserved in the majority of preterm infants","volume":"62","author":"Boardman","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/brain\/awl277","article-title":"Perinatal risk factors altering regional brain structure in the preterm infant","volume":"130","author":"Thompson","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jpeds.2015.09.083_bib26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-200010000-00005","article-title":"Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus","volume":"48","author":"Soul","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib27","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/brain\/awr052","article-title":"Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage","volume":"134","author":"Del Bigio","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jpeds.2015.09.083_bib28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1651-2227.2002.tb02834.x","article-title":"Cytokine response in cerebrospinal fluid from preterm infants with posthaemorrhagic ventricular dilatation","volume":"91","author":"Savman","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1203\/00006450-200102000-00013","article-title":"Nonprotein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation","volume":"49","author":"Savman","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1203\/01.pdr.0000220324.27597.f0","article-title":"Reduction in cerebellar volumes in preterm infants: relationship to white matter injury and neurodevelopment at two years of age","volume":"60","author":"Shah","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib31","series-title":"Neurology of the newborn","author":"Volpe","year":"2008"},{"key":"10.1016\/j.jpeds.2015.09.083_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuroimage.2006.03.029","article-title":"Abnormal deep grey matter development following preterm birth detected using deformation-based morphometry","volume":"32","author":"Boardman","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.jpeds.2015.09.083_bib33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1542\/peds.2006-2508","article-title":"Quantification of deep gray matter in preterm infants at term-equivalent age using manual volumetry of 3-tesla magnetic resonance images","volume":"119","author":"Srinivasan","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.09.083_bib34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.expneurol.2006.02.113","article-title":"Brain damage in neonatal rats following kaolin induction of hydrocephalus","volume":"200","author":"Khan","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib35","first-page":"573","article-title":"Smaller cerebellar volumes in very preterm infants at term-equivalent age are associated with the presence of supratentorial lesions","volume":"27","author":"Srinivasan","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib36","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1542\/peds.2004-1169","article-title":"Late gestation cerebellar growth is rapid and impeded by premature birth","volume":"115","author":"Limperopoulos","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2015.09.083_bib37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jmri.10205","article-title":"Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury","volume":"16","author":"Miller","year":"2002","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jpeds.2015.09.083_bib38","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00005072-199709000-00010","article-title":"Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible","volume":"56","author":"Del Bigio","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1750-3639.2004.tb00071.x","article-title":"Cellular damage and prevention in childhood hydrocephalus","volume":"14","author":"Del Bigio","year":"2004","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib40","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1203\/01.PDR.0000119370.21770.AC","article-title":"CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics","volume":"55","author":"Soul","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2015.09.083_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.braindev.2007.03.011","article-title":"Cerebral hemodynamics and oxygenation after serial CSF drainage in infants with PHVD","volume":"29","author":"van Alfen-van der Velden","year":"2007","journal-title":"Brain Dev"},{"key":"10.1016\/j.jpeds.2015.09.083_bib42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/apa.12942","article-title":"Decompressing posthaemorrhagic ventricular dilatation significantly improves regional cerebral oxygen saturation in preterm infants","volume":"104","author":"Norooz","year":"2015","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib43","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1651-2227.2010.01830.x","article-title":"Ultrasound measurements of the lateral ventricles in neonates: why, how and when? A systematic review","volume":"99","author":"Brouwer","year":"2010","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2015.09.083_bib44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pediatrneurol.2004.06.008","article-title":"Volumetric analysis of regional cerebral development in preterm children","volume":"31","author":"Kesler","year":"2004","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2015.09.083_bib45","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1001\/jama.284.15.1939","article-title":"Regional brain volume abnormalities and long-term cognitive outcome in preterm infants","volume":"284","author":"Peterson","year":"2000","journal-title":"JAMA"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615011579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615011579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:00:16Z","timestamp":1758358816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347615011579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":45,"alternative-id":["S0022347615011579"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.09.083","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Posthemorrhagic Ventricular Dilatation in the Preterm Infant\u00a0on\u00a0Brain Volumes and White Matter Diffusion Variables at\u00a0Term-Equivalent Age","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.09.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}