{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:35:59Z","timestamp":1792812959840,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 108160"],"award-info":[{"award-number":["R01 108160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jpeds.2015.12.038","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T17:52:27Z","timestamp":1453398747000},"page":"73-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation"],"prefix":"10.1016","volume":"171","author":[{"given":"Wendy","family":"Whiteside","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard E.","family":"Ostlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunkyung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Rocchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2015.12.038_bib1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1161\/CIRCULATIONAHA.114.005341","article-title":"Late consequences of the Fontan operation","volume":"130","author":"Rychik","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2015.12.038_bib2","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jpeds.2012.11.073","article-title":"Low total, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol levels in patients with complex congenital heart disease after Fontan palliation","volume":"162","author":"Whiteside","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2015.12.038_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/oxfordjournals.aje.a115479","article-title":"Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population","volume":"131","author":"Miettinen","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jpeds.2015.12.038_bib4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.numecd.2011.05.005","article-title":"The role of serum non-cholesterol sterols as surrogate markers of absolute cholesterol synthesis and absorption","volume":"21","author":"Miettinen","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jpeds.2015.12.038_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/ajcn\/43.1.92","article-title":"Serum plant sterols and their relation to cholesterol absorption","volume":"43","author":"Tilvis","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jpeds.2015.12.038_bib6","doi-asserted-by":"crossref","first-page":"e0116912","DOI":"10.1371\/journal.pone.0116912","article-title":"Plasma biomarker of dietary phytosterol intake","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2015.12.038_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0026-0495(89)90252-7","article-title":"Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men","volume":"38","author":"Miettinen","year":"1989","journal-title":"Metabolism"},{"key":"10.1016\/j.jpeds.2015.12.038_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.atherosclerosis.2007.08.003","article-title":"The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes","volume":"197","author":"Simonen","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jpeds.2015.12.038_bib9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1017\/S0007114507811998","article-title":"Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men","volume":"99","author":"Nissinen","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jpeds.2015.12.038_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0022-2275(20)43088-3","article-title":"The interaction of cholesterol absorption and cholesterol synthesis in man","volume":"10","author":"Grundy","year":"1969","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jpeds.2015.12.038_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1747-0803.2011.00504.x","article-title":"Liver disease in the Patient with Fontan Circulation","volume":"6","author":"Wu","year":"2011","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jpeds.2015.12.038_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/hrt.82.1.40","article-title":"Abnormalities in liver function and coagulation profile following the Fontan procedure","volume":"82","author":"van Nieuwenhuizen","year":"1999","journal-title":"Heart"},{"key":"10.1016\/j.jpeds.2015.12.038_bib13","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1136\/hrt.2010.201772","article-title":"Late hepatic complications after Fontan operation; non-invasive markers of hepatic fibrosis and risk factors","volume":"96","author":"Baek","year":"2010","journal-title":"Heart"},{"key":"10.1016\/j.jpeds.2015.12.038_bib14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/hrt.2006.094516","article-title":"Hepatic changes in the failing Fontan circulation","volume":"93","author":"Kiesewetter","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.jpeds.2015.12.038_bib15","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00246-012-0315-7","article-title":"The precarious state of the liver after a Fontan operation: summary of a multidisciplinary symposium","volume":"33","author":"Rychik","year":"2012","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jpeds.2015.12.038_bib16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/jcp.2007.052365","article-title":"Hepatic fibrosis and cirrhosis in the Fontan circulation: a detailed morphological study","volume":"61","author":"Kendall","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jpeds.2015.12.038_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijcard.2011.06.062","article-title":"Structural and functional uncoupling of liver performance in the Fontan circulation","volume":"164","author":"Guha","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jpeds.2015.12.038_bib18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.athoracsur.2006.02.048","article-title":"Protein-losing enteropathy after fontan operation: investigations into possible pathophysiologic mechanisms","volume":"82","author":"Ostrow","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jpeds.2015.12.038_bib19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1017\/S1047951113001650","article-title":"End-organ consequences of the Fontan operation: liver fibrosis, protein-losing enteropathy and plastic bronchitis","volume":"23","author":"Rychik","year":"2013","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jpeds.2015.12.038_bib20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated circulating levels of tumor necrosis factor in severe chronic heart failure","volume":"323","author":"Levine","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2015.12.038_bib21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11926-012-0269-z","article-title":"Lipid paradox in rheumatoid arthritis: changes with rheumatoid arthritis therapies","volume":"14","author":"Amezaga Urruela","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jpeds.2015.12.038_bib22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/ard.2008.101964","article-title":"Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions","volume":"68","author":"Choy","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jpeds.2015.12.038_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S1542-3565(04)00622-6","article-title":"High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics","volume":"3","author":"Habib","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jpeds.2015.12.038_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1001\/jama.291.4.451","article-title":"Association between cholesterol level and mortality in dialysis patients","volume":"291","author":"Liu","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2015.12.038_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1054\/jcaf.2002.0804216","article-title":"Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure","volume":"8","author":"Horwich","year":"2002","journal-title":"J Card Fail"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615016261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347615016261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T21:03:07Z","timestamp":1617570187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347615016261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":25,"alternative-id":["S0022347615016261"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.12.038","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2015.12.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}