{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:57:04Z","timestamp":1776459424851,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jpeds.2016.02.033","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T15:33:51Z","timestamp":1458142431000},"page":"76-83.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia"],"prefix":"10.1016","volume":"173","author":[{"given":"An N.","family":"Massaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Zaniletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"DiGeronimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.V.","family":"Dizon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon E.G.","family":"Hamrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit M.","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Dykes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Sysyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Coghill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramasubbareddy","family":"Dhanireddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanzeema","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Reber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmin","family":"Savani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Brion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Grover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautham","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Pallotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Joe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"D'Harlingue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquelyn","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Padula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Brozanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"McKay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Speziale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billie","family":"Short","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Di Geronimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Uhing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Meskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Grebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Wadhawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Asselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Dykes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquelyn","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Padula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Pallotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Reber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billie Lou","family":"Short","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2016.02.033_bib1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global,\u00a0regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2016.02.033_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJM198201283060404","article-title":"Identifying the sources of the recent decline in perinatal mortality rates in California","volume":"306","author":"Williams","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2016.02.033_bib3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1542\/peds.102.4.893","article-title":"Declining severity adjusted mortality: evidence of improving neonatal intensive care","volume":"102","author":"Richardson","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.033_bib4","first-page":"28","article-title":"How plans can improve outcomes and cut costs for preterm infant care","volume":"19","author":"Kornhauser","year":"2010","journal-title":"Manag Care"},{"key":"10.1016\/j.jpeds.2016.02.033_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1001\/jamapediatrics.2014.3566","article-title":"A risk-adjusted, composite outcomes score and resource utilization metrics for very low-birth-weight infants","volume":"169","author":"Kaempf","year":"2015","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jpeds.2016.02.033_bib6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/1471-0528.13515","article-title":"Economic costs associated with moderate and late preterm birth: a prospective population-based study","volume":"122","author":"Khan","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.jpeds.2016.02.033_bib7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/08830738010160110201","article-title":"Long-term developmental outcome of asphyxiated term neonates","volume":"16","author":"Dilenge","year":"2001","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","article-title":"Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants","volume":"25","author":"Shankaran","year":"1991","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2016.02.033_bib9","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2016.02.033_bib10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2016.02.033_bib11","doi-asserted-by":"crossref","first-page":"e1261","DOI":"10.1542\/peds.2010-2972A","article-title":"Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"126","author":"Kleinman","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.033_bib12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jp.2014.190","article-title":"Short-term outcomes after perinatal hypoxic ischemic encephalopathy: a report from the Children's Hospitals Neonatal Consortium HIE focus group","volume":"35","author":"Massaro","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib13","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/jp.2014.26","article-title":"The Children's Hospitals Neonatal Database: an overview of patient complexity, outcomes and variation in care","volume":"34","author":"Murthy","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib14","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.ahj.2010.08.010","article-title":"Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population","volume":"160","author":"Pasquali","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.jpeds.2016.02.033_bib15","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1001\/jama.299.17.2048","article-title":"Corticosteroids and mortality in children with bacterial meningitis","volume":"299","author":"Mongelluzzo","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2016.02.033_bib16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1001\/archpediatrics.2012.1266","article-title":"Prioritization of comparative effectiveness research topics in hospital pediatrics","volume":"166","author":"Keren","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2016.02.033_bib17","doi-asserted-by":"crossref","first-page":"F398","DOI":"10.1136\/archdischild-2011-301524","article-title":"Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy","volume":"97","author":"Shankaran","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.02.033_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archpediatrics.2012.284","article-title":"Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial","volume":"166","author":"Cheong","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2016.02.033_bib20","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1111\/j.1469-8749.2009.03550.x","article-title":"The predictive value of early neurological examination in neonatal hypoxic-ischaemic encephalopathy and neurodevelopmental outcome at 24 months","volume":"52","author":"Murray","year":"2010","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib21","doi-asserted-by":"crossref","first-page":"e553","DOI":"10.1542\/peds.2013-2870","article-title":"Variation in congenital heart surgery costs across hospitals","volume":"133","author":"Pasquali","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.033_bib22","article-title":"Relationship between severity of illness and length of stay on costs incurred during a pediatric critical care hospitalization","volume":"68","author":"Hsu","year":"2015","journal-title":"S D Med"},{"key":"10.1016\/j.jpeds.2016.02.033_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1017\/S0266462300009399","article-title":"Models for determining cost of care and length of stay in neonatal intensive care units","volume":"12","author":"Khoshnood","year":"1996","journal-title":"Int J Technol Assess Health Care"},{"issue":"Suppl 3","key":"10.1016\/j.jpeds.2016.02.033_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/dmcn.12727","article-title":"The long-term health, social, and financial burden of hypoxic-ischaemic encephalopathy","volume":"57","author":"Eunson","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1469-8749.2008.03190.x","article-title":"Lifetime costs of cerebral palsy","volume":"51","author":"Kruse","year":"2009","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib26","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ridd.2011.12.001","article-title":"Medical expenditures attributable to cerebral palsy and intellectual disability among Medicaid-enrolled children","volume":"33","author":"Kancherla","year":"2012","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jpeds.2016.02.033_bib27","first-page":"57","article-title":"Economic costs associated with mental retardation, cerebral palsy, hearing loss, and vision impairment\u2014United States, 2003","volume":"53","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jpeds.2016.02.033_bib28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1524-4733.2010.00731.x","article-title":"Cost-effectiveness of therapeutic hypothermia to treat neonatal encephalopathy","volume":"13","author":"Regier","year":"2010","journal-title":"Value Health"},{"key":"10.1016\/j.jpeds.2016.02.033_bib29","doi-asserted-by":"crossref","first-page":"e1181","DOI":"10.1542\/peds.2010-3742","article-title":"Inpatient costs and charges for surgical treatment of hypoplastic left heart syndrome","volume":"128","author":"Dean","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.033_bib30","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.AOG.0000445580.65983.d2","article-title":"Executive Summary. Neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists' Task Force on Neonatal Encephalopathy","volume":"123","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/WNP.0b013e31823e96d7","article-title":"The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates","volume":"28","author":"Shellhaas","year":"2011","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.jpeds.2016.02.033_bib32","doi-asserted-by":"crossref","first-page":"e38504","DOI":"10.1371\/journal.pone.0038504","article-title":"Implementation and conduct of therapeutic hypothermia for perinatal asphyxial encephalopathy in the UK\u2014analysis of national data","volume":"7","author":"Azzopardi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2016.02.033_bib33","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/apa.12830","article-title":"Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low-technology methods: a systematic review and meta-analysis","volume":"104","author":"Rossouw","year":"2015","journal-title":"Acta Paediatr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616001979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616001979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:54:47Z","timestamp":1536915287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347616001979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":33,"alternative-id":["S0022347616001979"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.02.033","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intercenter Cost Variation for Perinatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.03.018","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}