{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:58:48Z","timestamp":1790218728719,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jpeds.2016.02.064","type":"journal-article","created":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T15:50:47Z","timestamp":1459698647000},"page":"62-68.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"special_numbering":"C","title":["Risk Factors for Neonatal Arterial Ischemic Stroke: The Importance of the Intrapartum Period"],"prefix":"10.1016","volume":"173","author":[{"given":"Miriam","family":"Martinez-Biarge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanie L.Y.","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Diez-Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly M.S.","family":"Dubowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2016.02.064_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1542\/peds.2007-0336","article-title":"Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke","volume":"120","author":"Raju","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib2","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1161\/01.STR.31.10.2437","article-title":"Symptomatic ischemic stroke in full-term neonates: role of acquired and genetic prothrombotic risk factors","volume":"31","author":"G\u00fcnther","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2016.02.064_bib3","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1542\/peds.107.6.1400","article-title":"Prothrombotic disorders and abnormal neurodevelopmental outcome in infants with neonatal cerebral infarction","volume":"107","author":"Mercuri","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib4","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1161\/01.STR.0000103745.03393.39","article-title":"Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study","volume":"34","author":"Kurnik","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2016.02.064_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pediatrneurol.2007.04.007","article-title":"Risk factors for perinatal arterial stroke: a study of 60 mother-child pairs","volume":"37","author":"Curry","year":"2007","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/STROKEAHA.108.527283","article-title":"Factor V Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke","volume":"40","author":"Simchen","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2016.02.064_bib7","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.109.913673","article-title":"Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies","volume":"121","author":"Kenet","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2016.02.064_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1001\/jama.293.6.723","article-title":"Maternal and infant characteristics associated with perinatal arterial stroke in the infant","volume":"293","author":"Lee","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2016.02.064_bib9","doi-asserted-by":"crossref","first-page":"e1402","DOI":"10.1542\/peds.2011-1148","article-title":"Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study","volume":"128","author":"Kirton","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib10","doi-asserted-by":"crossref","first-page":"F411","DOI":"10.1136\/archdischild-2011-300973","article-title":"Risk factors for perinatal arterial ischaemic stroke in full-term infants: a case-control study","volume":"97","author":"Harteman","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.02.064_bib11","doi-asserted-by":"crossref","first-page":"e1220","DOI":"10.1542\/peds.2014-1520","article-title":"Incidence and outcomes of symptomatic neonatal arterial ischemic stroke","volume":"135","author":"Grunt","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib12","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/STROKEAHA.111.642181","article-title":"Antenatal factors associated with perinatal arterial ischemic stroke","volume":"43","author":"Darmency-Stamboul","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2016.02.064_bib13","doi-asserted-by":"crossref","first-page":"e90106","DOI":"10.1371\/journal.pone.0090106","article-title":"Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2016.02.064_bib14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1177\/0883073807304200","article-title":"Neonatal arterial ischemic stroke and sinovenous thrombosis associated with meningitis","volume":"22","author":"Fitzgerald","year":"2007","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib15","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.STR.0000247941.41234.90","article-title":"Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects","volume":"38","author":"McQuillen","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jpeds.2016.02.064_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/dmcn.12055","article-title":"Neonatal posterior cerebral artery stroke: clinical presentation, MRI findings, and outcome","volume":"55","author":"van der Aa","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(03)12658-X","article-title":"Origin and timing of brain lesions in term infants with neonatal encephalopathy","volume":"361","author":"Cowan","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2016.02.064_bib18","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1212\/01.WNL.0000129909.77753.C4","article-title":"Perinatal stroke in term infants with neonatal encephalopathy","volume":"62","author":"Ramaswamy","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2016.02.064_bib19","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1651-2227.2009.01461.x","article-title":"Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration","volume":"98","author":"Govaert","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2016.02.064_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-2008-1073018","article-title":"Early detection of cerebral infarction and hypoxic-ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging","volume":"25","author":"Cowan","year":"1994","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib21","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3174\/ajnr.A1480","article-title":"Evolution of unilateral perinatal arterial ischemic stroke on conventional and diffusion-weighted MR imaging","volume":"30","author":"Dudink","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib22","doi-asserted-by":"crossref","first-page":"F128","DOI":"10.1136\/fn.82.2.F128","article-title":"Cranial ultrasound abnormalities in full term infants in a postnatal ward: outcome at 12 and 18 months","volume":"82","author":"Haataja","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.02.064_bib23","doi-asserted-by":"crossref","first-page":"e952","DOI":"10.1542\/peds.2013-0511","article-title":"Antepartum and intrapartum factors preceding neonatal hypoxic-ischemic encephalopathy","volume":"132","author":"Martinez-Biarge","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1542\/peds.103.1.39","article-title":"Early prognostic indicators of outcome in infants with neonatal cerebral infarction: a clinical, electroencephalogram, and magnetic resonance imaging study","volume":"103","author":"Mercuri","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.02.064_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/STROKEAHA.108.521203","article-title":"International Pediatric Stroke Study Group. Male predominance in childhood ischemic stroke: findings from the international pediatric stroke study","volume":"40","author":"Golomb","year":"2009","journal-title":"Stroke"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2016.02.064_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2016.02.064_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(99)70172-9","article-title":"Fetal heart rate patterns in term labor vary with sex, gestational age, epidural analgesia, and fetal weight","volume":"180","author":"Dawes","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000077967","article-title":"Gender does matter in perinatal medicine","volume":"19","author":"Sheiner","year":"2004","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.jpeds.2016.02.064_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejogrb.2014.11.035","article-title":"Gender specific intrapartum and neonatal outcomes for term babies","volume":"185","author":"Dunn","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib30","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/bmj.317.7172.1549","article-title":"Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study","volume":"317","author":"Badawi","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2016.02.064_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.OGX.0000066802.19138.AE","article-title":"Cesarean delivery for fetal distress: rate and risk factors","volume":"58","author":"Chauhan","year":"2003","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.jpeds.2016.02.064_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/mrdd.10005","article-title":"Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm","volume":"8","author":"Dammann","year":"2002","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.jpeds.2016.02.064_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.1997.03550030047032","article-title":"Maternal infection and cerebral palsy in infants of normal birthweight","volume":"278","author":"Grether","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2016.02.064_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1471-0528.2002.01019.x","article-title":"Synergy between antenatal exposure to infection and intrapartum events in causation of perinatal brain injury at term","volume":"109","author":"Peebles","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.jpeds.2016.02.064_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.clp.2013.06.002","article-title":"The association between epidural labor analgesia and maternal fever","volume":"40","author":"Arendt","year":"2013","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2016.02.064_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1542\/peds.2006-2791","article-title":"Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging","volume":"119","author":"Fullerton","year":"2007","journal-title":"Pediatrics"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616002869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616002869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T14:53:14Z","timestamp":1536850394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347616002869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":36,"alternative-id":["S0022347616002869"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.02.064","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Factors for Neonatal Arterial Ischemic Stroke: The Importance of the Intrapartum Period","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.02.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}