{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:39:45Z","timestamp":1790206785396,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jpeds.2016.03.042","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T17:21:26Z","timestamp":1461950486000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"C","title":["Early Heart Rate Characteristics Predict Death and Morbidities in\u00a0Preterm\u00a0Infants"],"prefix":"10.1016","volume":"174","author":[{"given":"Brynne A.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"McClure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Randall","family":"Moorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2016.03.042_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1542\/peds.107.1.97","article-title":"Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel heart rate analysis","volume":"107","author":"Griffin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.03.042_bib2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1203\/01.PDR.0000064904.05313.D2","article-title":"Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness","volume":"53","author":"Griffin","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2016.03.042_bib3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1542\/peds.2004-2461","article-title":"Heart rate characteristics: novel physiomarkers to predict neonatal infection and death","volume":"116","author":"Griffin","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.03.042_bib4","doi-asserted-by":"crossref","first-page":"R789","DOI":"10.1152\/ajpregu.00069.2002","article-title":"Sample entropy analysis of neonatal heart rate variability","volume":"283","author":"Lake","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib5","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jpeds.2011.06.044","article-title":"Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial","volume":"159","author":"Moorman","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/pr.2013.136","article-title":"Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial","volume":"74","author":"Fairchild","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2016.03.042_bib7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/jp.2013.63","article-title":"Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis","volume":"33","author":"Stone","year":"2013","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jpeds.2013.11.038","article-title":"Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants","volume":"164","author":"Sullivan","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/jp.2014.18","article-title":"Abnormal heart rate characteristics are associated with abnormal neuroimaging and outcomes in extremely low birth weight infants","volume":"34","author":"Fairchild","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1203\/01.PDR.0000119366.21770.9E","article-title":"Abnormal heart rate characteristics are associated with neonatal mortality","volume":"55","author":"Griffin","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2016.03.042_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1067\/mpd.2001.109608","article-title":"SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores","volume":"138","author":"Richardson","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(03)13397-1","article-title":"CRIB II: an update of the clinical risk index for babies score","volume":"36","author":"Parry","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2016.03.042_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.jp.7210585","article-title":"SNAP-II predicts severe intraventricular hemorrhage and chronic lung disease in the neonatal intensive care unit","volume":"22","author":"Chien","year":"2002","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1471-2431-13-138","article-title":"Addition of SNAP to perinatal risk factors improves the prediction of bronchopulmonary dysplasia or death in critically ill preterm infants","volume":"13","author":"Li","year":"2013","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/14767050802046481","article-title":"Postnatal SNAP-II scores in neonatal intensive care unit patients: relationship to sepsis, necrotizing enterocolitis, and death","volume":"21","author":"Lim","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2016.03.042_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/MOP.0b013e32835e8fe6","article-title":"Predictive monitoring for early detection of sepsis in neonatal ICU patients","volume":"25","author":"Fairchild","year":"2013","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1542\/peds.91.3.617","article-title":"Score for Neonatal Acute Physiology: a physiologic severity index for neonatal intensive care","volume":"91","author":"Richardson","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2016.03.042_bib18","doi-asserted-by":"crossref","first-page":"R1019","DOI":"10.1152\/ajpregu.00132.2009","article-title":"Endotoxin depresses heart rate variability in mice: cytokine and steroid effects","volume":"297","author":"Fairchild","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1126\/scitranslmed.3001304","article-title":"Integration of early physiological responses predicts later illness severity in preterm infants","volume":"2","author":"Saria","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jpeds.2016.03.042_bib20","doi-asserted-by":"crossref","first-page":"F419","DOI":"10.1136\/adc.2003.031286","article-title":"Assessing mortality risk in very low birthweight infants: a comparison of CRIB, CRIB-II, and SNAPPE-II","volume":"89","author":"Gagliardi","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.03.042_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/14767050500072557","article-title":"Evaluating illness severity for very low birth weight infants: CRIB or CRIB-II?","volume":"17","author":"De Felice","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2016.03.042_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/adc.2008.148015","article-title":"Predicting neonatal mortality among very preterm infants: a comparison of three versions of the CRIB score","volume":"95","author":"Manktelow","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.03.042_bib23","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/jp.2009.81","article-title":"Heart rate characteristics and neurodevelopmental outcome in very low birth weight infants","volume":"29","author":"Addison","year":"2009","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2016.03.042_bib24","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1651-2227.2002.tb00105.x","article-title":"Can severity-of-illness indices for neonatal intensive care predict outcome at 4 years of age?","volume":"91","author":"Eriksson","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2016.03.042_bib25","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1136\/adc.2003.048488","article-title":"Neonatal disease severity scoring systems","volume":"90","author":"Dorling","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2016.03.042_bib26","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/nmo.12337","article-title":"Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants","volume":"26","author":"Doheny","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2016.03.042_bib27","doi-asserted-by":"crossref","first-page":"R330","DOI":"10.1152\/ajpregu.00487.2010","article-title":"Pathogen-induced heart rate changes associated with cholinergic nervous system activation","volume":"300","author":"Fairchild","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616004236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347616004236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T06:43:45Z","timestamp":1655621025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347616004236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":27,"alternative-id":["S0022347616004236"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.03.042","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Heart Rate Characteristics Predict Death and Morbidities in\u00a0Preterm\u00a0Infants","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2016.03.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}