{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:01:24Z","timestamp":1792645284584,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jpeds.2017.04.041","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T08:45:46Z","timestamp":1495529146000},"page":"34-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age"],"prefix":"10.1016","volume":"187","author":[{"given":"Janne Helen","family":"Skranes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro","family":"L\u00f8haugen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Margrethe","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damjan","family":"Osredkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Server","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances Mary","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Stiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drude","family":"Fugelseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Thoresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2017.04.041_bib0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/ana.23647","article-title":"Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy","volume":"72","author":"Volpe","year":"2012","journal-title":"Ann Neurol"},{"issue":"16 Suppl 2","key":"10.1016\/j.jpeds.2017.04.041_bib0015","doi-asserted-by":"crossref","first-page":"S516","DOI":"10.1161\/CIRCULATIONAHA.110.971127","article-title":"Part 11: neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"122","author":"Perlman","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomized controlled trial","volume":"8","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0030","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0035","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jpeds.2017.04.041_bib0040","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0045","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole- body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0050","doi-asserted-by":"crossref","first-page":"e771","DOI":"10.1542\/peds.2009-2441","article-title":"Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT","volume":"126","author":"Simbruner","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0055","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0060","first-page":"21","article-title":"Keeping a cool head","volume":"29","author":"Skranes","year":"2011","journal-title":"Paidos"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0065","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0070","series-title":"Atlas of procedures in neonatology","article-title":"Brain and whole body cooling","author":"Chakkarapani","year":"2012"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0075","article-title":"Rectal temperature in the first five hours after hypoxia-ischaemia critically affects neuropathological outcomes in neonatal rats","author":"Wood","year":"2017","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pediatrneurol.2004.09.014","article-title":"Electroencephalography in neonatal seizures: comparison of a reduced and a full 10\/20 montage","volume":"32","author":"Tekgul","year":"2005","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1542\/peds.2004-0863","article-title":"Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy","volume":"115","author":"Osredkar","year":"2005","journal-title":"Pediatrics"},{"issue":"6 Pt 1","key":"10.1016\/j.jpeds.2017.04.041_bib0090","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1542\/peds.103.6.1263","article-title":"Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography","volume":"103","author":"al Naqeeb","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0095","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1136\/fn.72.1.F34","article-title":"Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants","volume":"72","author":"Hellstrom-Westas","year":"1995","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0100","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1136\/fn.81.1.F19","article-title":"Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy","volume":"81","author":"Toet","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0105","series-title":"Atlas of amplitude-integrated EEGs in the newborn","author":"Hellstrom-Westas","year":"2008"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/archdischild-2013-305676","article-title":"How to use: amplitude-integrated EEG (aEEG)","volume":"100","author":"Shah","year":"2015","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0115","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/apa.13016","article-title":"Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth","volume":"104","author":"Skranes","year":"2015","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomized controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0125","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/j.1651-2227.2012.02778.x","article-title":"Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathy","volume":"101","author":"Thoresen","year":"2012","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0130","series-title":"Bayley scales of infant and toddler development","author":"Bayley","year":"2006"},{"issue":"2 Pt 1","key":"10.1016\/j.jpeds.2017.04.041_bib0135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-3476(99)70016-8","article-title":"Optimality score for the neurologic examination of the infant at 12 and 18 months of age","volume":"135","author":"Haataja","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0140","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/apa.12310","article-title":"Effect of primary language on developmental testing in children born extremely preterm","volume":"102","author":"Lowe","year":"2013","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0145","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/jp.2014.67","article-title":"Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III","volume":"34","author":"Chalak","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/pr.2014.47","article-title":"Maternal or neonatal infection: association with neonatal encephalopathy outcomes","volume":"76","author":"Jenster","year":"2014","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0155","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.2832","article-title":"Chi-squared and Fisher-Irwin tests of two-by-two tables with small sample recommendations","volume":"26","author":"Campbell","year":"2007","journal-title":"Stat Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0160","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude- integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.siny.2015.01.001","article-title":"Seizures and hypothermia: importance of electroencephalographic monitoring and considerations for treatment","volume":"20","author":"Boylan","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0170","doi-asserted-by":"crossref","first-page":"F267","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: an observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0175","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.siny.2014.10.006","article-title":"Prediction of outcome methods assessing short- and long-term outcome after therapeutic hypothermia","volume":"20","author":"Sabir","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0185","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.earlhumdev.2010.08.013","article-title":"Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy","volume":"86","author":"Martinez-Biarge","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0190","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jpeds.2012.04.054","article-title":"White matter and cortical injury in hypoxic-ischemic encephalopathy: antecedent factors and 2-year outcome","volume":"161","author":"Martinez-Biarge","year":"2012","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0195","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s00247-006-0164-8","article-title":"Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome","volume":"36","author":"Rutherford","year":"2006","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jpeds.2017.04.041_bib0200","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpeds.2015.12.023","article-title":"Brain volumes at term-equivalent age in preterm infants: imaging biomarkers for neurodevelopmental outcome through early school age","volume":"172","author":"Keunen","year":"2016","journal-title":"J Pediatr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347617305887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347617305887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T17:06:16Z","timestamp":1617555976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347617305887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":39,"alternative-id":["S0022347617305887"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2017.04.041","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2017.04.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}