{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:37:51Z","timestamp":1764603471964,"version":"3.44.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01NS092764","1U01NS077953"],"award-info":[{"award-number":["1U01NS092764","1U01NS077953"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jpeds.2017.08.031","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T17:44:33Z","timestamp":1507830273000},"page":"22-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Neuroprotective Strategies in Neonatal Brain Injury"],"prefix":"10.1016","volume":"192","author":[{"given":"Pratik","family":"Parikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-3639","authenticated-orcid":false,"given":"Sandra E.","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2017.08.031_bib0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0015","doi-asserted-by":"crossref","first-page":"e49023","DOI":"10.1371\/journal.pone.0049023","article-title":"Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damage","volume":"7","author":"Brehmer","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0020","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1442-200X.2010.03290.x","article-title":"New insights into the pathogenesis of perinatal hypoxic-ischemic brain injury","volume":"53","author":"Vasiljevic","year":"2011","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0025","first-page":"278","article-title":"Follow-up of the term infant after hypoxic-ischemic encephalopathy","volume":"11","author":"Robertson","year":"2006","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0030","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis","volume":"385","author":"Liu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0035","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1523\/JNEUROSCI.21-06-01931.2001","article-title":"Delayed neurodegeneration in neonatal rat thalamus after hypoxia- ischemia is apoptosis","volume":"21","author":"Northington","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0040","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/00006250-200512000-00056","article-title":"Inappropriate use of the terms fetal distress and birth asphyxia. Committee Opinion No. 326","volume":"106","author":"American College of Obstetricians and Gynecologists","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0045","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.AOG.0000445580.65983.d2","article-title":"Executive summary: neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists' Task Force on Neonatal Encephalopathy","volume":"123","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0050","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0055","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jpeds.2011.07.015","article-title":"Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy","volume":"159","author":"Glass","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0060","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1212\/WNL.0b013e31821f442d","article-title":"Predicting motor outcome and death in term hypoxic-ischemic encephalopathy","volume":"76","author":"Martinez-Biarge","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0065","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.earlhumdev.2010.08.013","article-title":"Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy","volume":"86","author":"Martinez-Biarge","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0070","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/02699052.2016.1231344","article-title":"Head injury serum markers for assessing response to trauma: design of the HeadSMART study","volume":"31","author":"Peters","year":"2017","journal-title":"Brain Inj"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jocn.2016.12.009","article-title":"Plasma micro-RNA biomarkers for diagnosis and prognosis after traumatic brain injury: a pilot study","volume":"38","author":"Mitra","year":"2017","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0080","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cca.2015.08.021","article-title":"Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid","volume":"450","author":"Lv","year":"2015","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000370147","article-title":"Serial plasma metabolites following hypoxic-ischemic encephalopathy in a nonhuman primate model","volume":"37","author":"Chun","year":"2015","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0090","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.chroma.2011.01.086","article-title":"Application of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry method to identify potential biomarkers of perinatal asphyxia in a non-human primate model","volume":"1218","author":"Beckstrom","year":"2011","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0095","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.3390\/molecules20047000","article-title":"Perinatal asphyxia: a review from a metabolomics perspective","volume":"20","author":"Fattuoni","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0100","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1021\/pr400617m","article-title":"1H NMR derived metabolomic profile of neonatal asphyxia in umbilical cord serum: implications for hypoxic ischemic encephalopathy","volume":"12","author":"Reinke","year":"2013","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000446556","article-title":"Early cord metabolite index and outcome in perinatal asphyxia and hypoxic-ischaemic encephalopathy","volume":"110","author":"Ahearne","year":"2016","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2011.30","article-title":"Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy","volume":"71","author":"Guillet","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0115","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpeds.2016.11.019","article-title":"Safety and short-term outcomes of therapeutic hypothermia in preterm neonates 34-35 weeks gestational age with hypoxic-ischemic encephalopathy","volume":"183","author":"Rao","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0130","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1001\/jama.2014.16058","article-title":"Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial","volume":"312","author":"Shankaran","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0135","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12098-016-2266-0","article-title":"Therapeutic hypothermia for birth asphyxia in neonates","volume":"84","author":"Datta","year":"2017","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0145","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02253360","article-title":"Actions of melatonin in the reduction of oxidative stress. A review","volume":"7","author":"Reiter","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0150","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1096\/fj.10-154450","article-title":"Melatonin signaling and cell protection function","volume":"24","author":"Luchetti","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0155","doi-asserted-by":"crossref","first-page":"9379","DOI":"10.3390\/ijms14059379","article-title":"Neuroprotective effect of melatonin: a novel therapy against perinatal hypoxia-ischemia","volume":"14","author":"Alonso-Alconada","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0160","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/dmcn.12415","article-title":"Is melatonin ready to be used in preterm infants as a neuroprotectant?","volume":"56","author":"Biran","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0165","first-page":"771","article-title":"Histological study of the protective effect of melatonin on neural cells after neonatal hypoxia-ischemia","volume":"27","author":"Alonso-Alconada","year":"2012","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0170","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1442-200x.2005.02085.x","article-title":"The protective role of melatonin in experimental hypoxic brain damage","volume":"47","author":"Tutunculer","year":"2005","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0175","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1600-079X.2008.00639.x","article-title":"Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin","volume":"46","author":"Signorini","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-079X.2007.00503.x","article-title":"Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats","volume":"44","author":"Carloni","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0185","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/bpa.12272","article-title":"Antioxidant treatments recover the alteration of auditory-evoked potentials and reduce morphological damage in the inferior colliculus after perinatal asphyxia in rat","volume":"26","author":"Revuelta","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0190","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/jp.2014.186","article-title":"Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study","volume":"35","author":"Aly","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0200","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.1998.tb00550.x","article-title":"Maternal-fetal transfer of melatonin in pregnant women near term","volume":"25","author":"Okatani","year":"1998","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1600-079X.1988.tb00787.x","article-title":"Plasma, cerebrospinal fluid, and brain distribution of 14C-melatonin in rat: a biochemical and autoradiographic study","volume":"5","author":"Vitte","year":"1988","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0210","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/24525","article-title":"How does xenon produce anaesthesia?","volume":"396","author":"Franks","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0215","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/01.anes.0000264762.48920.80","article-title":"Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain","volume":"106","author":"Ma","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0220","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jnr.23178","article-title":"Hypothermia and xenon: novel noble guardians in hypoxic-ischemic encephalopathy?","volume":"91","author":"Lobo","year":"2013","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0225","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(15)00347-6","article-title":"Moderate hypothermia within 6\u2009h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial","volume":"15","author":"Azzopardi","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0230","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/nbdi.2000.0371","article-title":"Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis","volume":"8","author":"Northington","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0235","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1097\/CCM.0b013e3182452164","article-title":"The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*","volume":"40","author":"Zhuang","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0240","doi-asserted-by":"crossref","first-page":"e113575","DOI":"10.1371\/journal.pone.0113575","article-title":"Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets","volume":"9","author":"Alderliesten","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0245","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3727\/000000006783982034","article-title":"Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury","volume":"15","author":"Yasuhara","year":"2006","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2009.03.003","article-title":"Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes","volume":"61","author":"van Velthoven","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0255","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1203\/PDR.0b013e3181bf594b","article-title":"Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model","volume":"67","author":"Lee","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0260","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0265","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1523\/JNEUROSCI.1835-10.2010","article-title":"Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function","volume":"30","author":"van Velthoven","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0270","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbi.2011.03.021","article-title":"Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain","volume":"25","author":"van Velthoven","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0275","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1634\/stemcells.2005-0614","article-title":"Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells","volume":"24","author":"Rivera","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0280","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbi.2009.10.017","article-title":"Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration","volume":"24","author":"van Velthoven","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0285","doi-asserted-by":"crossref","first-page":"e0120893","DOI":"10.1371\/journal.pone.0120893","article-title":"Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy","volume":"10","author":"Park","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0290","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/stem.1304","article-title":"Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial","volume":"31","author":"Min","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0295","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy","volume":"164","author":"Cotten","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0300","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.129.2.505","article-title":"Erythropoietin receptor signalling is required for normal brain development","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0305","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2007.03.001","article-title":"Role of erythropoietin in the brain","volume":"64","author":"Noguchi","year":"2007","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0310","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/pr.2013.155","article-title":"Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury","volume":"74","author":"Jantzie","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0315","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/cercor\/bhu066","article-title":"Postnatal erythropoietin mitigates impaired cerebral cortical development following subplate loss from prenatal hypoxia-ischemia","volume":"25","author":"Jantzie","year":"2015","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0320","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0325","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1203\/pdr.0b013e3180332cec","article-title":"A comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats","volume":"61","author":"Kellert","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0330","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000232558","article-title":"Erythropoietin sustains cognitive function and brain volume after neonatal stroke","volume":"31","author":"Gonzalez","year":"2009","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0335","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2016.04.006","article-title":"Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke","volume":"93","author":"Larpthaveesarp","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0340","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1542\/peds.2007-2711","article-title":"A phase I\/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety","volume":"122","author":"Juul","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0345","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2012-0498","article-title":"Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics","volume":"130","author":"Wu","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0350","doi-asserted-by":"crossref","first-page":"e20160191","DOI":"10.1542\/peds.2016-0191","article-title":"High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: a phase II trial","volume":"137","author":"Wu","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0355","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1542\/peds.2008-3553","article-title":"Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy","volume":"124","author":"Zhu","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0360","doi-asserted-by":"crossref","first-page":"e1135","DOI":"10.1542\/peds.2009-2268","article-title":"Human recombinant erythropoietin in asphyxia neonatorum: pilot trial","volume":"125","author":"Elmahdy","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0365","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/jp.2017.17","article-title":"Erythropoietin monotherapy in perinatal asphyxia with moderate to severe encephalopathy: a randomized placebo-controlled trial","volume":"37","author":"Malla","year":"2017","journal-title":"J Perinatol"},{"issue":"suppl 1","key":"10.1016\/j.jpeds.2017.08.031_bib0370","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1054\/bjoc.2001.1746","article-title":"Development and characterization of novel erythropoiesis stimulating protein (NESP)","volume":"84","author":"Egrie","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0375","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","article-title":"The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid","volume":"6","author":"Aruoma","year":"1989","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0380","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jnr.20087","article-title":"Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke","volume":"76","author":"Khan","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0385","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ana.21066","article-title":"N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury","volume":"61","author":"Wang","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0390","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1203\/01.pdr.0000215045.91122.44","article-title":"Combination of systemic hypothermia and n-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats","volume":"59","author":"Jatana","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/967087","article-title":"Protective effects of N-acetyl-L-cysteine in human oligodendrocyte progenitor cells and restoration of motor function in neonatal rats with hypoxic-ischemic encephalopathy","volume":"2015","author":"Park","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0400","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neures.2016.01.008","article-title":"Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia","volume":"108","author":"Nie","year":"2016","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0405","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00134-007-0880-z","article-title":"Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain","volume":"34","author":"Lee","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0410","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2015.07.009","article-title":"Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury","volume":"214","author":"Nance","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0415","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1073\/pnas.0937423100","article-title":"Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia\/reperfusion model","volume":"100","author":"Ren","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0420","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuropharm.2007.06.020","article-title":"Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia","volume":"53","author":"Yan","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0425","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1073\/pnas.96.15.8745","article-title":"Lithium activates the serine\/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons","volume":"96","author":"Chalecka-Franaszek","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0430","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.0022-3042.2001.00728.x","article-title":"Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation","volume":"80","author":"Hashimoto","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0435","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1074\/jbc.274.10.6039","article-title":"Long term lithium treatment suppresses p53 and bax expression but increases Bcl-2 Expression: a prominent role in neuroprotection against excitotoxicity","volume":"274","author":"Chen","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0440","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/WNF.0000000000000028","article-title":"The effect of lithium in post-stroke motor recovery","volume":"37","author":"Mohammadianinejad","year":"2014","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0445","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1038\/cddis.2010.33","article-title":"Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia","volume":"1","author":"Li","year":"2010","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0450","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/138945011794182764","article-title":"Lithium and its neuroprotective and neurotrophic effects: potential treatment for post-ischemic stroke sequelae","volume":"12","author":"Gold","year":"2011","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0455","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1038\/jcbfm.2011.75","article-title":"Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem\/progenitor cells","volume":"31","author":"Li","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0460","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mcn.2012.07.002","article-title":"Lithium reduced neural progenitor apoptosis in the hippocampus and ameliorated functional deficits after irradiation to the immature mouse brain","volume":"51","author":"Huo","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0465","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.4161\/cbt.6.12.5161","article-title":"New enlightenment of French Paradox: resveratrol's potential for cancer chemoprevention and anti-cancer therapy","volume":"6","author":"Liu","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0470","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2013.03.015","article-title":"Resveratrol protects spinal cord dorsal column from hypoxic injury by activating Nrf-2","volume":"241","author":"Kesherwani","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0475","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejphar.2011.05.015","article-title":"Ischemic insult induced apoptotic changes in PC12 cells: protection by trans resveratrol","volume":"666","author":"Agrawal","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0480","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2006.06.096","article-title":"Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus","volume":"1111","author":"Gao","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0485","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000105477","article-title":"Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury","volume":"29","author":"West","year":"2007","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0490","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3345\/kjp.2008.51.10.1102","article-title":"Neuroprotective effects of resveratrol via anti-apoptosis on hypoxic-ischemic brain injury in neonatal rats","volume":"51","author":"Shin","year":"2008","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0495","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2011.09.044","article-title":"Resveratrol ameliorates hypoxia\/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain","volume":"1425","author":"Karalis","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0500","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1203\/01.PDR.0000157722.07810.15","article-title":"Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury","volume":"57","author":"Loren","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0505","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.placenta.2012.01.012","article-title":"Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia","volume":"33","author":"Bourque","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0510","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","article-title":"Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia","volume":"1282","author":"Yang","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0515","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1002\/anie.201107724","article-title":"Curcumin-from molecule to biological function","volume":"51","author":"Esatbeyoglu","year":"2012","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0520","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-0-387-46401-5_10","article-title":"Molecular targets of curcumin","volume":"595","author":"Lin","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0525","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1742-2094-11-59","article-title":"Curcumin attenuates acute inflammatory injury by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway in experimental traumatic brain injury","volume":"11","author":"Zhu","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0530","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/187152006776930918","article-title":"Biological effects of curcumin and its role in cancer chemoprevention and therapy","volume":"6","author":"Singh","year":"2006","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0535","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11064-009-0065-y","article-title":"Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats","volume":"35","author":"Zhao","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0540","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbr.2008.06.012","article-title":"Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat","volume":"193","author":"Dohare","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0545","first-page":"1","article-title":"Curcumin protects neuron against cerebral ischemia-induced inflammation through improving PPAR-gamma function","volume":"2013","author":"Liu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0550","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3109\/10799893.2015.1006331","article-title":"Protection of curcumin against amyloid-beta-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+elevation","volume":"35","author":"Huang","year":"2015","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0555","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt\/\u03b2-catenin pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpeds.2017.08.031_bib0560","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejpb.2013.02.005","article-title":"Curcumin loaded solid lipid nanoparticles: an efficient formulation approach for cerebral ischemic reperfusion injury in rats","volume":"85","author":"Kakkar","year":"2013","journal-title":"Eur J Pharm Biopharm"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347617310910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347617310910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:58:44Z","timestamp":1758358724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347617310910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":111,"alternative-id":["S0022347617310910"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2017.08.031","relation":{},"ISSN":["0022-3476"],"issn-type":[{"type":"print","value":"0022-3476"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective Strategies in Neonatal Brain Injury","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2017.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2017.07.050","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}