{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:50:04Z","timestamp":1747165804092,"version":"3.40.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA-11431","RO1-HD057100","R21-NS096525"],"award-info":[{"award-number":["AA-11431","RO1-HD057100","R21-NS096525"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jpeds.2018.01.052","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T23:06:51Z","timestamp":1521241611000},"page":"286-291.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neuroinflammation-Related Encephalopathy in an Infant Born Preterm Following Exposure to Maternal Diabetic Ketoacidosis"],"prefix":"10.1016","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-332X","authenticated-orcid":false,"given":"David E.","family":"Mandelbaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Arsenault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-7683","authenticated-orcid":false,"given":"Barbara S.","family":"Stonestreet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-3210","authenticated-orcid":false,"given":"Stefan","family":"Kostadinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"de la Monte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2018.01.052_bib0010","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1001\/jama.1984.03340380025017","article-title":"Obstetric complications as risk factors for cerebral palsy or seizure disorders","volume":"251","author":"Nelson","year":"1984","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/adc.65.2.201","article-title":"Cerebral palsy in very low birthweight infants","volume":"65","author":"Cooke","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(90)90002-Z","article-title":"White matter damage in preterm newborns\u2014an epidemiologic perspective","volume":"24","author":"Leviton","year":"1990","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0025","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/adc.65.6.602","article-title":"Birthweight specific trends in cerebral palsy","volume":"65","author":"Pharoah","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0378-3782(94)90035-3","article-title":"The aetiology of cerebral palsy","volume":"36","author":"Stanley","year":"1994","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0035","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1067\/mob.2003.204","article-title":"Temporal and demographic trends in cerebral palsy\u2014fact and fiction","volume":"188","author":"Clark","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0002-9378(98)70387-4","article-title":"Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight","volume":"179","author":"Nelson","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1542\/peds.64.2.225","article-title":"Neonatal signs as predictors of cerebral palsy","volume":"64","author":"Nelson","year":"1979","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0050","first-page":"1333","article-title":"The asymptomatic newborn and risk of cerebral palsy","volume":"141","author":"Nelson","year":"1987","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1071-9091(98)80034-X","article-title":"Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant","volume":"5","author":"Dammann","year":"1998","journal-title":"Semin Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-3476(00)90004-0","article-title":"Brain damage in preterm newborns: biological response modification as a strategy to reduce disabilities","volume":"136","author":"Dammann","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.31887\/DCNS.2014.16.3\/jbolton","article-title":"Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms","volume":"16","author":"Bolton","year":"2014","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00726-017-2495-1","article-title":"Taurine counteracts the neurotoxic effects of streptozotocin-induced diabetes in rats","volume":"50","author":"Caletti","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0080","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2015.06.063","article-title":"Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring","volume":"303","author":"Chandna","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0085","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1055\/s-0036-1582397","article-title":"Inflammation in complicated pregnancy and its outcome","volume":"33","author":"Kalagiri","year":"2016","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0090","doi-asserted-by":"crossref","first-page":"6219730","DOI":"10.1155\/2016\/6219730","article-title":"Effect of associated autoimmune diseases on type 1 diabetes mellitus incidence and metabolic control in children and adolescents","volume":"2016","author":"Krzewska","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0095","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.tem.2016.08.007","article-title":"Immune and pancreatic beta cell interactions in type 1 diabetes","volume":"27","author":"Boldison","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0100","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.2337\/diacare.26.11.2990","article-title":"French multicentric survey of outcome of pregnancy in women with pregestational diabetes","volume":"26","author":"Boulot","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/bmj.315.7103.275","article-title":"Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study","volume":"315","author":"Casson","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0110","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/bmj.38043.583160.EE","article-title":"Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study in the Netherlands","volume":"328","author":"Evers","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/bmj.315.7103.279","article-title":"Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994","volume":"315","author":"Hawthorne","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1471-0528.2003.02067.x","article-title":"Outcomes of pregnancies in women with type 1 diabetes in Scotland: a national population-based study","volume":"110","author":"Penney","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.1464-5491.2002.00756.x","article-title":"Congenital anomalies and first life year surveillance in type 1 diabetic births","volume":"19","author":"Vaarasmaki","year":"2002","journal-title":"Diabet Med"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0130","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/pmj.79.934.454","article-title":"Diabetic ketoacidosis in pregnancy","volume":"79","author":"Kamalakannan","year":"2003","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11892-013-0457-x","article-title":"Inpatient management of women with gestational and pregestational diabetes in pregnancy","volume":"14","author":"Garrison","year":"2014","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0140","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2337\/diacare.26.3.958","article-title":"Pregnancy complicated by diabetic ketoacidosis: maternal and fetal outcomes","volume":"26","author":"Schneider","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000457617","article-title":"Effects of prolonged fetal hyperinsulinemia on plasma catecholamines, circulation and oxygen metabolism in utero","volume":"15","author":"Stonestreet","year":"1990","journal-title":"Dev Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0150","first-page":"H1098","article-title":"Circulatory and metabolic effects of beta-adrenergic blockade in the hyperinsulinemic ovine fetus","volume":"265","author":"Stonestreet","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1203\/00006450-199507000-00012","article-title":"Circulatory and metabolic effects of hypoxia in the hyperinsulinemic ovine fetus","volume":"38","author":"Stonestreet","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0160","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1203\/00006450-198208000-00013","article-title":"Arterial hypoxemia and hyperinsulinemia in the chronically hyperglycemic fetal lamb","volume":"16","author":"Philips","year":"1982","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2007-994692","article-title":"Outcome of pregnancy in diabetic ketoacidosis","volume":"10","author":"Montoro","year":"1993","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0170","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/14767058.2012.714643","article-title":"Multiple organ failure syndrome in the newborn: morphological and immunohistochemical data","volume":"25","author":"Faa","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clp.2013.09.007","article-title":"Pathogenesis and prevention of intraventricular hemorrhage","volume":"41","author":"Ballabh","year":"2014","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11064-016-2099-2","article-title":"beta-hydroxybutyrate in the brain: one molecule, multiple mechanisms","volume":"42","author":"Achanta","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0185","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1203\/01.PDR.0000139415.96985.BF","article-title":"Effects of exogenous glucose on brain ischemia in ovine fetuses","volume":"56","author":"Petersson","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0190","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jpeds.2010.11.059","article-title":"The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN study","volume":"158","author":"Leviton","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0195","first-page":"435","article-title":"Plasma C-reactive protein levels in severe diabetic ketoacidosis","volume":"33","author":"Dalton","year":"2003","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0200","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/PCC.0b013e31816c7082","article-title":"Cerebral edema in diabetic ketoacidosis","volume":"9","author":"Levin","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0205","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1464-5491.2005.01453.x","article-title":"Insights into the acute cerebral metabolic changes associated with childhood diabetes","volume":"22","author":"Cameron","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0210","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF00856852","article-title":"Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances: II","volume":"6","author":"Trachtman","year":"1992","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0215","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3171\/jns.1976.44.4.0409","article-title":"Nonketotic hyperglycemic hyperosmolar coma. Report of neurosurgical cases with a review of mechanisms and treatment","volume":"44","author":"Park","year":"1976","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0220","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/jcbfm.2011.114","article-title":"Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs","volume":"32","author":"Stonestreet","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2013.04.012","article-title":"Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring","volume":"33","author":"Mandal","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0230","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/dneu.22052","article-title":"Maternal and fetal antibrain antibodies in development and disease","volume":"72","author":"Fox","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0235","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nm.1892","article-title":"Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus","volume":"15","author":"Lee","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0240","doi-asserted-by":"crossref","first-page":"F355","DOI":"10.1136\/adc.2010.195099","article-title":"Cerebral ultrasound abnormalities in infants born to mothers with autoimmune disease","volume":"96","author":"Motta","year":"2011","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2018.01.052_bib0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archpedi.157.4.397","article-title":"Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children","volume":"157","author":"Ross","year":"2003","journal-title":"Arch Pediatr Adolesc Med"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618301306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618301306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T06:56:47Z","timestamp":1660633007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347618301306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":48,"alternative-id":["S0022347618301306"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.01.052","relation":{},"ISSN":["0022-3476"],"issn-type":[{"type":"print","value":"0022-3476"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinflammation-Related Encephalopathy in an Infant Born Preterm Following Exposure to Maternal Diabetic Ketoacidosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.01.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}