{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:17:50Z","timestamp":1793614670949,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP #93596"],"award-info":[{"award-number":["MOP #93596"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["84290"],"award-info":[{"award-number":["84290"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jpeds.2018.04.051","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T22:04:32Z","timestamp":1527113072000},"page":"50-57.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Cardiopulmonary Adaptation During First Day of Life in Human Neonates"],"prefix":"10.1016","volume":"200","author":[{"given":"Amish","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakesh S.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.W.","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif","family":"EL-Khuffash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Jankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2018.04.051_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.105.1.14","article-title":"Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes","volume":"105","author":"Walsh-Sukys","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0015","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1515\/jpm-2015-0210","article-title":"Clinical characteristics and factors associated with term and late preterm infants that do not respond to inhaled nitric oxide (iNO)","volume":"44","author":"Morel","year":"2016","journal-title":"J Perinat Med"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0020","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1067\/mpd.2002.122730","article-title":"Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide","volume":"140","author":"Lipkin","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1542\/peds.28.1.28","article-title":"Pulmonary vascular adjustments in the neonatal period","volume":"28","author":"Rudolph","year":"1961","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0030","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.echo.2014.08.018","article-title":"Comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and Z scores","volume":"27","author":"Jain","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0035","article-title":"Left ventricular function in healthy term neonates during the transitional period","volume":"182","author":"Jain","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0050","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.echo.2011.03.008","article-title":"Pulmonary artery acceleration time provides an accurate estimate of systolic pulmonary arterial pressure during transthoracic echocardiography","volume":"24","author":"Yared","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0055","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.echo.2016.08.013","article-title":"Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children","volume":"29","author":"Levy","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0060","doi-asserted-by":"crossref","first-page":"H691","DOI":"10.1152\/ajpheart.00653.2002","article-title":"Echocardiographic measurement of cardiac output in rats","volume":"284","author":"Slama","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0065","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0735-1097(10)80076-2","article-title":"Doppler echocardiographic measurement of pulmonary artery pressure from ductal Doppler velocities in the newborn","volume":"15","author":"Musewe","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jpeds.2006.10.056","article-title":"Functional echocardiography: an emerging clinical tool for the neonatologist","volume":"150","author":"Kluckow","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0075","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1055\/s-0037-1603733","article-title":"Management of the third stage of labor: how delayed umbilical cord clamping can affect neonatal outcome","volume":"34","author":"Kresch","year":"2017","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/japplphysiol.01358.2013","article-title":"Ventilation\/perfusion mismatch during lung aeration at birth","volume":"117","author":"Lang","year":"2014","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0085","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1113\/JP270926","article-title":"Increase in pulmonary blood flow at birth: role of oxygen and lung aeration","volume":"594","author":"Lang","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0090","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1113\/jphysiol.2009.174870","article-title":"Dynamic changes in the direction of blood flow through the ductus arteriosus at birth","volume":"587","author":"Crossley","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0095","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/aogs.13060","article-title":"Placental pulsatility index: a new, more sensitive parameter for predicting adverse outcome in pregnancies suspected of fetal growth restriction","volume":"96","author":"Gudmundsson","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000368880","article-title":"The influence of crying on the ductus arteriosus shunt and left ventricular output at birth","volume":"107","author":"van Vonderen","year":"2015","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0105","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0002-9149(86)90076-7","article-title":"Factors affecting use of the Doppler-determined time from flow onset to maximal pulmonary artery velocity for measurement of pulmonary artery pressure in children","volume":"58","author":"Serwer","year":"1986","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0735-1097(87)80047-5","article-title":"Comparison of three Doppler ultrasound methods in the prediction of pulmonary artery pressure","volume":"9","author":"Chan","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0115","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/0002-9149(84)90646-5","article-title":"Doppler echocardiographic prediction of pulmonary arterial hypertension in congenital heart disease","volume":"53","author":"Kosturakis","year":"1984","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0120","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0002-9149(99)80419-6","article-title":"Noninvasive assessment of myocardial contractility, preload, and afterload in healthy newborn infants","volume":"75","author":"Rowland","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0033-0620(72)90006-0","article-title":"The intrinsic physiologic properties of the developing heart","volume":"15","author":"Friedman","year":"1972","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000240225","article-title":"Cardiac output in newborn infants","volume":"15","author":"Emmanouilides","year":"1970","journal-title":"Biol Neonate"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0135","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1542\/peds.36.5.752","article-title":"Hemodynamic adaptations in the newborn infant","volume":"36","author":"Gessner","year":"1965","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0140","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jpeds.2011.12.008","article-title":"Transitional changes in cardiac and cerebral hemodynamics in term neonates at birth","volume":"160","author":"Noori","year":"2012","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0145","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000330052","article-title":"Noninvasive assessment of the early transitional circulation in healthy term infants","volume":"101","author":"Popat","year":"2012","journal-title":"Neonatology."},{"key":"10.1016\/j.jpeds.2018.04.051_bib0150","first-page":"213","article-title":"Non-invasive evaluation of the adaptations of cardiac function in the neonatal period: a comparison of healthy infants delivered by vaginal route and caesarean section","volume":"55","author":"Coskun","year":"2001","journal-title":"Acta Med Okayama"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0155","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/adc.64.10_Spec_No.1374","article-title":"Left ventricular output during postnatal circulatory adaptation in healthy infants born at full term","volume":"64","author":"Winberg","year":"1989","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0160","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/01.CIR.103.12.1662","article-title":"Cardiac output and central distribution of blood flow in the human fetus","volume":"103","author":"Mielke","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0165","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1651-2227.1996.tb13922.x","article-title":"Pulmonary artery pressure in term and preterm neonates","volume":"85","author":"Randala","year":"1996","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0170","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0022-3476(87)80263-9","article-title":"Two-dimensional Doppler echocardiographic assessment of closure of the ductus arteriosus in normal newborn infants","volume":"111","author":"Hiraishi","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0175","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0022-3476(81)80719-6","article-title":"Pulsed Doppler echocardiographic determination of time of ductal closure in normal newborn infants","volume":"98","author":"Gentile","year":"1981","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0180","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0022-3476(88)80333-0","article-title":"Duration of ductal shunting in healthy preterm infants: an echocardiographic color flow Doppler study","volume":"112","author":"Reller","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0185","doi-asserted-by":"crossref","first-page":"F408","DOI":"10.1136\/archdischild-2014-306033","article-title":"Non-invasive measurements of ductus arteriosus flow directly after birth","volume":"99","author":"van Vonderen","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0190","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/01.RES.57.6.811","article-title":"Distribution and regulation of blood flow in the fetal and neonatal lamb","volume":"57","author":"Rudolph","year":"1985","journal-title":"Circ Res"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1113\/jphysiol.1952.sp004769","article-title":"The effect of ventilation of the foetal lungs upon the pulmonary circulation","volume":"118","author":"Ardran","year":"1952","journal-title":"J Physiol"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0200","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0022-3476(64)80395-4","article-title":"Pulmonary arterial pressure changes in human newborn infants from birth to 3 days of age","volume":"65","author":"Emmanouilides","year":"1964","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2018.04.051_bib0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1515\/JPM.2000.011","article-title":"Fetal venous circulation\u2014an update on hemodynamics","volume":"28","author":"Kiserud","year":"2000","journal-title":"J Perinat Med"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761830605X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234761830605X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:01:58Z","timestamp":1758358918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234761830605X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":40,"alternative-id":["S002234761830605X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.04.051","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiopulmonary Adaptation During First Day of Life in Human Neonates","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.04.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}