{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:30:49Z","timestamp":1776058249037,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jpeds.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T01:06:56Z","timestamp":1530493616000},"page":"320-323.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Diagnostic Delay in Erythropoietic Protoporphyria"],"prefix":"10.1016","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-7465","authenticated-orcid":false,"given":"Sajel M.","family":"Lala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hetanshi","family":"Naik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-5011","authenticated-orcid":false,"given":"Manisha","family":"Balwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2018.06.001_bib0010","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"Erythropoietic protoporphyria, autosomal recessive","author":"Balwani","year":"2012"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0015","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"X-linked protoporphyria","author":"Balwani","year":"2013"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0020","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/jamadermatol.2017.1557","article-title":"Clinical, biochemical, and genetic characterization of North American patients with erythropoietic protoporphyria and X-linked protoporphyria","volume":"153","author":"Balwani","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0025","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/bjd.13598","article-title":"Long-term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria","volume":"172","author":"Biolcati","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0030","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1373\/clinchem.2015.245456","article-title":"Pitfalls in erythrocyte protoporphyrin measurement for diagnosis and monitoring of protoporphyrias","volume":"61","author":"Gou","year":"2015","journal-title":"Clin Chem"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0035","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1365-2133.2006.07472.x","article-title":"Erythropoietic protoporphyria in the U.K.: clinical features and effect on quality of life","volume":"155","author":"Holme","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40257-016-0184-6","article-title":"Afamelanotide: a review in erythropoietic protoporphyria","volume":"17","author":"Kim","year":"2016","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/TACG.S122030","article-title":"Advances in the management of erythropoietic protoporphyria\u2014role of afamelanotide","volume":"9","author":"Lane","year":"2016","journal-title":"Appl Clin Genet"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1172-4-19","article-title":"Erythropoietic protoporphyria","volume":"4","author":"Lecha","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0055","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/0006-2952(84)90565-3","article-title":"Effect of cimetidine on \u03b4-aminolevulinic acid synthase and microsomal heme oxygenase in rat liver","volume":"33","author":"Marcus","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/jamadermatol.2016.4049","article-title":"Insufficient evidence of cimetidine benefit in protoporphyria","volume":"153","author":"Langendonk","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0065","first-page":"84","article-title":"A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria","volume":"55","author":"Minder","year":"2009","journal-title":"Cell Mol Biol (Noisy-Le-Grand)"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0070","first-page":"44","article-title":"Erythropoietic protoporphyria: a case report and literature review","volume":"3","author":"Michaels","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0075","series-title":"Psychosocial issues in erythropoietic protoporphyria: the perspectives of parents, children, and young adults","author":"Naik","year":"2017"},{"key":"10.1016\/j.jpeds.2018.06.001_bib0080","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2006-0833","article-title":"Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria","author":"Rand","year":"2006","journal-title":"Pediatrics"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618307704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618307704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T04:11:34Z","timestamp":1543896694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347618307704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":15,"alternative-id":["S0022347618307704"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.06.001","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic Delay in Erythropoietic Protoporphyria","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}