{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:42:21Z","timestamp":1781739741701,"version":"3.54.5"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jpeds.2018.07.061","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:51:53Z","timestamp":1536886313000},"page":"185-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome"],"prefix":"10.1016","volume":"203","author":[{"given":"Veeral N.","family":"Tolia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-9663","authenticated-orcid":false,"given":"Karna","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-8543","authenticated-orcid":false,"given":"Rachel G.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Brian","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2018.07.061_bib0010","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009","volume":"307","author":"Patrick","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0015","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jp.2015.36","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012","volume":"35","author":"Patrick","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0020","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1056\/NEJMsa1500439","article-title":"Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs","volume":"372","author":"Tolia","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0025","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3835","article-title":"Improving care for neonatal abstinence syndrome","volume":"137","author":"Patrick","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0030","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0035","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/jp.2014.194","article-title":"Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial","volume":"35","author":"Brown","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0040","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/jp.2014.114","article-title":"Variation in treatment of neonatal abstinence syndrome in US children's hospitals, 2004-2011","volume":"34","author":"Patrick","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0045","doi-asserted-by":"crossref","first-page":"e527","DOI":"10.1542\/peds.2013-4036","article-title":"A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome","volume":"134","author":"Hall","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clp.2010.01.016","article-title":"The Pediatrix BabySteps Data Warehouse and the Pediatrix QualitySteps improvement project system\u2013tools for \u201cmeaningful use\u201d in continuous quality improvement","volume":"37","author":"Spitzer","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0055","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.0006-341X.2000.00645.x","article-title":"A note on robust variance estimation for cluster-correlated data","volume":"56","author":"Williams","year":"2000","journal-title":"Biometrics"},{"issue":"10 Suppl 2","key":"10.1016\/j.jpeds.2018.07.061_bib0060","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1097\/MLR.0b013e31806518ac","article-title":"Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases","volume":"45","author":"Curtis","year":"2007","journal-title":"Med Care"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0065","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1056\/NEJMoa1005359","article-title":"Neonatal abstinence syndrome after methadone or buprenorphine exposure","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/AOG.0000000000000640","article-title":"Buprenorphine and naloxone compared with methadone treatment in pregnancy","volume":"125","author":"Wiegand","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/jp.2017.157","article-title":"Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome","volume":"38","author":"Tolia","year":"2018","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0080","doi-asserted-by":"crossref","first-page":"e547","DOI":"10.1542\/peds.2013-3524","article-title":"Neonatal abstinence syndrome","volume":"134","author":"Kocherlakota","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1542\/hpeds.2017-0077","article-title":"Hospital variation in neonatal abstinence syndrome incidence, treatment modalities, resource use, and costs across pediatric hospitals in the United States, 2013 to 2016","volume":"8","author":"Milliren","year":"2018","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0090","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.pcl.2012.07.006","article-title":"Pharmacologic management of the opioid neonatal abstinence syndrome","volume":"59","author":"Kraft","year":"2012","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0095","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3520","article-title":"Incidence and costs of neonatal abstinence syndrome among infants with Medicaid: 2004-2014","volume":"141","author":"Winkelman","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0100","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-2929","article-title":"Rooming-in to treat neonatal abstinence syndrome: improved family-centered care at lower cost","volume":"137","author":"Holmes","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2018.07.061_bib0105","series-title":"Morphine vs. methadone for the treatment of neonatal abstinence syndrome","author":"Davis","year":"2018"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618309673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347618309673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T05:03:12Z","timestamp":1542690192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347618309673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":20,"alternative-id":["S0022347618309673"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.07.061","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2018.07.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}