{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:03:56Z","timestamp":1787497436623,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Cerus Corporation"},{"name":"Cerus Corporation"},{"DOI":"10.13039\/100006432","name":"Terumo BCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006432","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grifols Diagnostics"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jpeds.2019.01.046","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T09:27:49Z","timestamp":1552642069000},"page":"220-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Blood Utilization and Transfusion Reactions in Pediatric Patients Transfused with Conventional or Pathogen Reduced Platelets"],"prefix":"10.1016","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-4028","authenticated-orcid":false,"given":"Wade L.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"McPadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Gehrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-7973","authenticated-orcid":false,"given":"Burak","family":"Bahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gokhale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan R.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.jpeds.2019.01.046_bib1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/trf.14165","article-title":"Continued decline in blood collection and transfusion in the United States-2015","volume":"57","author":"Ellingson","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1046\/j.1537-2995.2002.00203.x","article-title":"Blood collection and transfusion in the United States in 1997","volume":"42","author":"Sullivan","year":"2002","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-3148.2009.00933.x","article-title":"The EASTR Study: indications for transfusion and estimates of transfusion recipient numbers in hospitals supplied by the National Blood Service","volume":"19","author":"Wells","year":"2009","journal-title":"Transfus Med"},{"key":"10.1016\/j.jpeds.2019.01.046_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/tme.12283","article-title":"Transfusion in children: epidemiology and 10-year survival of transfusion recipients","volume":"26","author":"Morley","year":"2016","journal-title":"Transfus Med"},{"key":"10.1016\/j.jpeds.2019.01.046_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1423-0410.2010.01378.x","article-title":"Survival after transfusion in the Netherlands","volume":"100","author":"Borkent-Raven","year":"2011","journal-title":"Vox Sang"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2019.01.046_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/14767058.2011.607586","article-title":"Blood transfusion in infants: techniques and adverse events","volume":"24","author":"Fanaro","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2019.01.046_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.siny.2015.11.001","article-title":"Thrombocytopenia and platelet transfusion in the neonate","volume":"21","author":"Cremer","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"issue":"5 Pt 1","key":"10.1016\/j.jpeds.2019.01.046_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0022-3476(86)81059-9","article-title":"Frequency and mechanism of neonatal thrombocytopenia","volume":"108","author":"Castle","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.01.046_bib9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0022-3476(80)80272-1","article-title":"Thrombocytopenia in the high-risk infant","volume":"97","author":"Mehta","year":"1980","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.01.046_bib10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/sj.jp.7211509","article-title":"Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system","volume":"26","author":"Christensen","year":"2006","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2019.01.046_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1537-2995.2007.01484.x","article-title":"Blood transfusions in children: a multi-institutional analysis of practices and complications","volume":"48","author":"Slonim","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib12","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1046\/j.1537-2995.2002.00202.x","article-title":"Hemovigilance network in France: organization and analysis of immediate transfusion incident reports from 1994 to 1998","volume":"42","author":"Andreu","year":"2002","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01363-18","article-title":"Atypical bacterial growth within units of platelets challenges transfusion medicine dogma","volume":"56","author":"Gehrie","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jpeds.2019.01.046_bib14","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/trf.14789","article-title":"The epidemiology of bacterial culture-positive and septic transfusion reactions at a large tertiary academic center: 2009 to 2016","volume":"58","author":"Erony","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib15","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/trf.14618","article-title":"Implementation of secondary bacterial culture testing of platelets to mitigate residual risk of septic transfusion reactions","volume":"58","author":"Bloch","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01105-18","article-title":"Bordetella holmesii contamination of platelet concentrates: revisiting the definition of a positive culture","volume":"56","author":"Cloutier","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jpeds.2019.01.046_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/trf.15139","article-title":"Financial impact of alternative approaches to reduce bacterial contamination of platelet transfusions","author":"Kacker","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.transci.2008.05.003","article-title":"Pathogen reduction of blood components","volume":"39","author":"Solheim","year":"2008","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.jpeds.2019.01.046_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/0885066618756589","article-title":"Efforts toward elimination of infectious agents in blood products","volume":"33","author":"Jacquot","year":"2018","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.jpeds.2019.01.046_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fmed.2018.00129","article-title":"Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets","volume":"5","author":"Schubert","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jpeds.2019.01.046_bib23","first-page":"CD009072","article-title":"Pathogen-reduced platelets for the prevention of bleeding","volume":"7","author":"Estcourt","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jpeds.2019.01.046_bib24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/jamaoncol.2017.5123","article-title":"Comparison of the hemostatic efficacy of pathogen-reduced platelets vs untreated platelets in patients with thrombocytopenia and malignant hematologic diseases: a randomized clinical trial","volume":"4","author":"Garban","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jpeds.2019.01.046_bib25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/trf.14042","article-title":"Clinical effectiveness of platelets in additive solution treated with two commercial pathogen-reduction technologies","volume":"57","author":"Rebulla","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/vox.12456","article-title":"Impact of platelet pathogen inactivation on blood component utilization and patient safety in a large Austrian Regional Medical Centre","volume":"112","author":"Amato","year":"2017","journal-title":"Vox Sang"},{"key":"10.1016\/j.jpeds.2019.01.046_bib27","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1182\/blood-2003-12-4443","article-title":"Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial","volume":"104","author":"McCullough","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2019.01.046_bib28","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.13979.1","article-title":"Recent advances in transfusions in neonates\/infants","volume":"7","author":"Goel","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.jpeds.2019.01.046_bib29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/trf.14811","article-title":"Pathogen-inactivated blood products for pediatric patients: blood safety, patient safety, or both?","volume":"58","author":"Jacquot","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib30","series-title":"A scalable data science platform for healthcare and precision medicine research","author":"McPadden","year":"2018"},{"key":"10.1016\/j.jpeds.2019.01.046_bib32","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1111\/j.1537-2995.2010.02694.x","article-title":"A randomized controlled clinical trial evaluating the performance and safety of platelets treated with MIRASOL pathogen reduction technology","volume":"50","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.jpeds.2019.01.046_bib33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.transci.2018.05.022","article-title":"Special considerations for the use of pathogen reduced blood components in pediatric patients: an overview","volume":"57","author":"Goodrich","year":"2018","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.jpeds.2019.01.046_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/jamaoncol.2017.5049","article-title":"Pathogen-reduced platelets for the prevention of bleeding in people of any age","volume":"4","author":"Estcourt","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jpeds.2019.01.046_bib35","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJMoa0904084","article-title":"Dose of prophylactic platelet transfusions and prevention of hemorrhage","volume":"362","author":"Slichter","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2019.01.046_bib36","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood-2011-11-389569","article-title":"Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia","volume":"120","author":"Josephson","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jpeds.2019.01.046_bib37","series-title":"Circular of information for the use of human blood and blood\u00a0components","year":"2017"},{"key":"10.1016\/j.jpeds.2019.01.046_bib38","doi-asserted-by":"crossref","first-page":"e1046","DOI":"10.1542\/peds.2011-1494","article-title":"Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"128","author":"Bhutani","year":"2011","journal-title":"Pediatrics"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619301362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619301362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:01:46Z","timestamp":1758358906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347619301362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":35,"alternative-id":["S0022347619301362"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.01.046","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735359059.793569563","asserted-by":"object"}]},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood Utilization and Transfusion Reactions in Pediatric Patients Transfused with Conventional or Pathogen Reduced Platelets","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}