{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:44:42Z","timestamp":1791319482906,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jpeds.2019.06.004","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T12:20:45Z","timestamp":1563452445000},"page":"137-142.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy"],"prefix":"10.1016","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-546X","authenticated-orcid":false,"given":"Rita","family":"Nocerino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Di Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Cosenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Maddalena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Di Scala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Della Gatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Carucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Voto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Iannicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Berni Canani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2019.06.004_bib1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"150","author":"Hyams","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2019.06.004_bib2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2019.06.004_bib3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ajg.2010.512","article-title":"Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia","volume":"106","author":"Liebregts","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib4","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/eci.12548","article-title":"Immune dysregulation in the functional gastrointestinal disorders","volume":"45","author":"Keely","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jpeds.2019.06.004_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11894-011-0197-5","article-title":"The role of eosinophils and mast cells in intestinal functional disease","volume":"13","author":"Walker","year":"2011","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.jpeds.2019.06.004_bib6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2036.2009.03937.x","article-title":"Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia","volume":"29","author":"Walker","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2019.06.004_bib7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/jgh.12419","article-title":"Duodenal eosinophilia and early satiety in functional dyspepsia: confirmation of a positive association in an Australian cohort","volume":"29","author":"Walker","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib8","doi-asserted-by":"crossref","first-page":"E1836","DOI":"10.3390\/nu10121836","article-title":"Probiotics on pediatric functional gastrointestinal disorders","volume":"10","author":"P\u00e4rtty","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jpeds.2019.06.004_bib9","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jaci.2010.11.044","article-title":"Epidemiology of food allergy","volume":"127","author":"Sicherer","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41591-018-0324-z","article-title":"Healthy infants harbor intestinal bacteria that protect against food allergy","volume":"25","author":"Feehley","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jpeds.2019.06.004_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MPG.0b013e3181e85b55","article-title":"Cow's milk allergy is a risk factor for the development of FGIDs in children","volume":"52","author":"Saps","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2019.06.004_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpeds.2017.10.073","article-title":"Allergic proctocolitis is a risk factor for functional gastrointestinal disorders in children","volume":"195","author":"Di Nardo","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.06.004_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/MPG.0000000000001219","article-title":"Preschoolers with allergic diseases have an increased risk of irritable bowel syndrome when reaching school age","volume":"64","author":"Tan","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpeds.2019.06.004_bib14","doi-asserted-by":"crossref","first-page":"E1716","DOI":"10.3390\/nu10111716","article-title":"Cow's milk protein allergy in infancy: a risk factor for functional gastrointestinal disorders in children?","volume":"10","author":"Pensabene","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jpeds.2019.06.004_bib15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/apt.15120","article-title":"Population-based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress","volume":"49","author":"Koloski","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2019.06.004_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1744-313X.1981.tb00959.x","article-title":"The association of an HLA \u201casthma-associated\u201d haplotype and immediate hypersensitivity in familial asthma","volume":"8","author":"Brady","year":"1981","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.jpeds.2019.06.004_bib17","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.humimm.2014.06.022","article-title":"HLA and asthma phenotypes\/endotypes: a review","volume":"75","author":"Kontakioti","year":"2014","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib18","doi-asserted-by":"crossref","first-page":"G1262","DOI":"10.1152\/ajpgi.00294.2012","article-title":"Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea","volume":"303","author":"Vazquez-Roque","year":"2012","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jpeds.2009.09.012","article-title":"Lactobacillus GG improves recovery in infants with blood in the stools and presumptive allergic colitis compared with extensively hydrolyzed formula alone","volume":"156","author":"Baldassarre","year":"2010","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.06.004_bib20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jaci.2011.10.004","article-title":"Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: a randomized trial","volume":"129","author":"Berni Canani","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib21","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jpeds.2013.03.008","article-title":"Formula selection for management of children with cow's milk allergy influences the rate of acquisition of tolerance: a prospective multicenter study","volume":"163","author":"Berni Canani","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.06.004_bib22","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.jaci.2016.10.050","article-title":"Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial","volume":"139","author":"Berni Canani","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib23","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/ismej.2015.151","article-title":"Lactobacillus rhamnosus GG supplemented formula expands butyrate producing bacterial strains in food allergic infants","volume":"10","author":"Berni Canani","year":"2016","journal-title":"ISME J"},{"key":"10.1016\/j.jpeds.2019.06.004_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13148-015-0070-8","article-title":"Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy","volume":"7","author":"Berni Canani","year":"2015","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jpeds.2019.06.004_bib25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13148-016-0252-z","article-title":"Epigenetic features of FoxP3 in children with cow's milk allergy","volume":"8","author":"Paparo","year":"2016","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.jpeds.2019.06.004_bib26","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpeds.2019.06.004_bib27","series-title":"Multivariable model-building: A pragmatic approach to regression analysis based on fractional polynomials for modelling continuous variables","author":"Royston","year":"2008"},{"key":"10.1016\/j.jpeds.2019.06.004_bib28","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1536867X1201200209","article-title":"Using the margins command to estimate and interpret adjusted predictions and marginal effects","volume":"12","author":"Williams","year":"2012","journal-title":"Stata J"},{"key":"10.1016\/j.jpeds.2019.06.004_bib29","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/sim.4780141908","article-title":"Exact logistic regression: theory and examples","volume":"14","author":"Mehta","year":"1995","journal-title":"Stat Med"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2019.06.004_bib30","first-page":"19","article-title":"Efficacy of butyrate in the treatment of diarrhoea-predominant irritable bowel syndrome","author":"Scarpellini","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jpeds.2019.06.004_bib31","first-page":"350","article-title":"Butyric acid in irritable bowel syndrome","volume":"8","author":"Za\u0142\u0119ski","year":"2013","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.jpeds.2019.06.004_bib32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.5056\/jnm18071","article-title":"Role of gut microbiota-gut hormone axis in the pathophysiology of functional gastrointestinal disorders","volume":"24","author":"Fukui","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jpeds.2019.06.004_bib33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.phrs.2015.11.026","article-title":"Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice","volume":"103","author":"Russo","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jpeds.2019.06.004_bib34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem Int"}],"updated-by":[{"DOI":"10.1016\/j.jpeds.2019.10.013","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000}},{"DOI":"10.1016\/j.jpeds.2021.01.025","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000}}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619306985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619306985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T20:27:58Z","timestamp":1645216078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347619306985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":34,"alternative-id":["S0022347619306985"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.06.004","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jpeds.2021.01.025","asserted-by":"object"},{"id-type":"doi","id":"10.1016\/j.jpeds.2019.10.013","asserted-by":"object"}]},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}