{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:21:59Z","timestamp":1788009719268,"version":"build-2784847793"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eunice Kennedy Shriver National Institute"},{"name":"Child Health & Human Development"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 HD091365"],"award-info":[{"award-number":["K23 HD091365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jpeds.2019.12.056","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T08:13:38Z","timestamp":1580976818000},"page":"126-132.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-8146","authenticated-orcid":false,"given":"Kevin J.","family":"Downes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.K.","family":"Boge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elande","family":"Baro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold T.","family":"Wharton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie M.","family":"Liston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany L.","family":"Haltzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Doe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Fulchiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong","family":"Lieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-1405","authenticated-orcid":false,"given":"Sara L.","family":"Van Driest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison G.","family":"Grisso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida T.","family":"Aka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Gillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie S.","family":"Pingel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Coffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2019.12.056_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1542\/peds.108.2.223","article-title":"Natural history of neonatal herpes simplex virus infections in the acyclovir era","volume":"108","author":"Kimberlin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2019.12.056_bib2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2010-0134","article-title":"Incidence of neonatal herpes simplex virus infections in the United States, 2006","volume":"127","author":"Flagg","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2019.12.056_bib3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/OLQ.0b013e31821b178f","article-title":"Population-based surveillance for neonatal herpes in New York City, April 2006-September 2010","volume":"38","author":"Handel","year":"2011","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.jpeds.2019.12.056_bib4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/01.olq.0000258432.33412.e2","article-title":"Incidence of neonatal herpes simplex virus infections in a managed-care population","volume":"34","author":"Whitley","year":"2007","journal-title":"Sex Transm Dis"},{"issue":"2","key":"10.1016\/j.jpeds.2019.12.056_bib5","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-1688","article-title":"Herpes simplex virus infection in infants undergoing meningitis evaluation","volume":"141","author":"Cruz","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2019.12.056_bib6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1542\/peds.2011-0177","article-title":"Delayed acyclovir therapy and death among neonates with herpes simplex virus infection","volume":"128","author":"Shah","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2019.12.056_bib7","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1136\/eb-2012-100674","article-title":"Delayed acyclovir therapy in neonates with herpes simplex virus infection is associated with an increased odds of death compared with early therapy","volume":"18","author":"Long","year":"2013","journal-title":"Evid Based Med"},{"key":"10.1016\/j.jpeds.2019.12.056_bib8","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jpeds.2015.01.023","article-title":"Intravenous acyclovir and renal dysfunction in children: a matched case control study","volume":"166","author":"Rao","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2019.12.056_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/INF.0000000000001451","article-title":"Safety of high-dose acyclovir in infants with suspected and confirmed neonatal herpes simplex virus infections","volume":"36","author":"Ericson","year":"2017","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jpeds.2019.12.056_bib10","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1542\/peds.2014-3819","article-title":"Neonatal acute kidney injury","volume":"136","author":"Selewski","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2019.12.056_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1053\/j.ajkd.2005.02.010","article-title":"Antiviral drug-induced nephrotoxicity","volume":"45","author":"Izzedine","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jpeds.2019.12.056_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.jpeds.2019.12.056_bib13","first-page":"166","article-title":"Glomerular function in neonates","volume":"6","author":"Hoseini","year":"2012","journal-title":"Iran J Kidney Dis"},{"key":"10.1016\/j.jpeds.2019.12.056_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MOP.0b013e32834f62d5","article-title":"Update on acute kidney injury in the neonate","volume":"24","author":"Jetton","year":"2012","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jpeds.2019.12.056_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-virology-092917-043457","article-title":"Antiviral approaches for the treatment of herpes simplex virus infections in newborn infants","volume":"5","author":"Poole","year":"2018","journal-title":"Ann Rev Virol"},{"key":"10.1016\/j.jpeds.2019.12.056_bib16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/0886022X.2018.1487866","article-title":"The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration","volume":"40","author":"Lee","year":"2018","journal-title":"Ren Fail"},{"key":"10.1016\/j.jpeds.2019.12.056_bib17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.2015.115","article-title":"Phenotype standardization for drug-induced kidney disease","volume":"88","author":"Mehta","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.jpeds.2019.12.056_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.kint.2016.03.031","article-title":"A sustained quality improvement program reduces nephrotoxic medication-associated acute kidney injury","volume":"90","author":"Goldstein","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.jpeds.2019.12.056_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1099800414531483","article-title":"Comparison of renal function indicators according to hydration volume in patients receiving intravenous acyclovir with CNS infection","volume":"17","author":"Kim","year":"2015","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.jpeds.2019.12.056_bib20","doi-asserted-by":"crossref","first-page":"e756","DOI":"10.1542\/peds.2013-0794","article-title":"Electronic health record identification of nephrotoxin exposure and associated acute kidney injury","volume":"132","author":"Goldstein","year":"2013","journal-title":"Pediatrics"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619317354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347619317354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:02:50Z","timestamp":1758358970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347619317354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":20,"alternative-id":["S0022347619317354"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.12.056","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2019.12.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}