{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:00:24Z","timestamp":1790020824529,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007305","name":"Maternal and Child Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jpeds.2020.04.066","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T02:35:00Z","timestamp":1588732500000},"page":"156-163.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Hypertension during Diabetic Ketoacidosis in Children"],"prefix":"10.1016","volume":"223","author":[{"given":"Andrew","family":"DePiero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Kuppermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff E.","family":"Schunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"McManemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arleta","family":"Rewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Tzimenatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Garro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage R.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S.","family":"Quayle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise E.","family":"Nigrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody S.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Charles","family":"Casper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2020.04.066_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/archdischild-2011-300173","article-title":"Dehydration in children with diabetic ketoacidosis: a prospective study","volume":"97","author":"Sottosanti","year":"2012","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2020.04.066_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1399-5448.2010.00695.x","article-title":"Hypertension despite dehydration during severe pediatric diabetic ketoacidosis","volume":"12","author":"Deeter","year":"2011","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2020.04.066_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/PEC.0b013e31827b564e","article-title":"Hypertension in severe pediatric diabetic ketoacidosis: case report and review of literature","volume":"29","author":"Bin Salleh","year":"2013","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.jpeds.2020.04.066_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.85.1.16","article-title":"The risk and outcome of cerebral oedema developing during diabetic ketoacidosis","volume":"85","author":"Edge","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2020.04.066_bib5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1056\/NEJM200101253440404","article-title":"Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics","volume":"344","author":"Glaser","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2020.04.066_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jpeds.2004.12.041","article-title":"Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis","volume":"146","author":"Lawrence","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2020.04.066_bib7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1067\/mpd.2002.128888","article-title":"Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema","volume":"141","author":"Marcin","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2020.04.066_bib8","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1097\/PCC.0b013e3182196c6d","article-title":"Risk factors for cerebral edema in diabetic ketoacidosis in a developing country: role of fluid refractory shock","volume":"13","author":"Tiwari","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2020.04.066_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1399-543X.2006.00156.x","article-title":"Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis","volume":"7","author":"Glaser","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2020.04.066_bib10","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jpeds.2013.06.008","article-title":"Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children","volume":"163","author":"Glaser","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2020.04.066_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jpeds.2016.09.003","article-title":"Regional brain water content and distribution during diabetic ketoacidosis","volume":"180","author":"Glaser","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2020.04.066_bib12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/PCC.0000000000000197","article-title":"Transcranial Doppler-based assessment of cerebral autoregulation in critically ill children during diabetic ketoacidosis treatment","volume":"15","author":"Ma","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2020.04.066_bib13","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1056\/NEJMoa1716816","article-title":"Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis","volume":"378","author":"Kuppermann","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2020.04.066_bib14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/pedi.12027","article-title":"Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial","volume":"14","author":"Glaser","year":"2013","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2020.04.066_bib15","series-title":"Fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. [NIH Publication No. 05-5267]","year":"2005"},{"key":"10.1016\/j.jpeds.2020.04.066_bib16","series-title":"Resting pulse rate reference data for children, adolescents, and adults: United States, 1999-2008. Number 41, August 24","year":"2011"},{"key":"10.1016\/j.jpeds.2020.04.066_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2337\/diacare.18.2.245","article-title":"The use of areas under curves in diabetes research","volume":"18","author":"Allison","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2020.04.066_bib18","first-page":"1","article-title":"Improving Global Outcomes (KDIGO) acute kidney injury work group. KDIGO Clinical Practical Guideline for Acute Kidney Injury","volume":"2","author":"Kidney Disease","year":"2012","journal-title":"Kidney Int Supplement"},{"key":"10.1016\/j.jpeds.2020.04.066_bib19","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2337\/diacare.27.7.1541","article-title":"Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings, and early identification","volume":"27","author":"Muir","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2020.04.066_bib20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1056\/NEJM197310182891607","article-title":"Hyperglycemia-induced hyponatremia\u2014calculation of expected serum sodium depression","volume":"289","author":"Katz","year":"1973","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2020.04.066_bib21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00006565-199112000-00008","article-title":"Paradoxical hypertension in hypovolemic children","volume":"7","author":"Bissler","year":"1991","journal-title":"Pediatric Emergency Care"},{"key":"10.1016\/j.jpeds.2020.04.066_bib22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpeds.2004.03.045","article-title":"Mechanism of cerebral edema in children with diabetic ketoacidosis","volume":"145","author":"Glaser","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2020.04.066_bib23","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/HYPERTENSIONAHA.114.04683","article-title":"Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat","volume":"65","author":"Marina","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.jpeds.2020.04.066_bib24","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0140-6736(71)92245-8","article-title":"Increased cerebrospinal-fluid pressure during treatment of diabetic ketosis","volume":"298","author":"Clements","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2020.04.066_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.0954-6820.1970.tb08006.x","article-title":"Total exchangeable sodium in chronic nephropathy with and without hypertension","volume":"1","author":"Friis","year":"1970","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jpeds.2020.04.066_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0140-6736(73)91476-1","article-title":"Abnormal relation between exchangeable sodium and the renin-angiotensin system in malignant hypertension and in hypertension with chronic renal failure","volume":"1","author":"Davies","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2020.04.066_bib27","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/BF00277316","article-title":"Central role for sodium in the pathogenesis of blood pressure changes independent of angiotensin, aldosterone and catecholamines in type 1 (insulin-dependent) diabetes mellitus","volume":"30","author":"Feldt-Rasmussen","year":"1987","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2020.04.066_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ckj\/sfx087","article-title":"Angiotensinogen as a biomarker of acute kidney injury","volume":"10","author":"Habeeb Ba Aqeel","year":"2017","journal-title":"Clin Kidney J"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347620305709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347620305709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:04:28Z","timestamp":1758359068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347620305709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":28,"alternative-id":["S0022347620305709"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2020.04.066","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypertension during Diabetic Ketoacidosis in Children","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2020.04.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}