{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:46:33Z","timestamp":1792176393415,"version":"4.4.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009993","name":"Center for Clinical and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jpeds.2020.10.030","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T02:09:44Z","timestamp":1602900584000},"page":"154-160.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Development and Validation of a Model to Predict Neonatal Abstinence Syndrome"],"prefix":"10.1016","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-0371","authenticated-orcid":false,"given":"Stephen W.","family":"Patrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Slaughter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Frank E.","family":"Harrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Dudley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William O.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2020.10.030_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.15585\/mmwr.mm6731a1","article-title":"Opioid use disorder documented at delivery hospitalization - United States, 1999-2014","volume":"67","author":"Haight","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jpeds.2020.10.030_bib2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-3520","article-title":"Incidence and costs of neonatal abstinence syndrome among infants with medicaid: 2004-2014","volume":"141","author":"Winkelman","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2020.10.030_bib3","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009","volume":"307","author":"Patrick","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2020.10.030_bib4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jp.2015.36","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012","volume":"35","author":"Patrick","year":"2015","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2020.10.030_bib5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1542\/peds.2014-3299","article-title":"Prescription opioid epidemic and infant outcomes","volume":"135","author":"Patrick","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2020.10.030_bib6","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2020.10.030_bib7","doi-asserted-by":"crossref","first-page":"j3326","DOI":"10.1136\/bmj.j3326","article-title":"Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study","volume":"358","author":"Huybrechts","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2020.10.030_bib8","doi-asserted-by":"crossref","first-page":"h2102","DOI":"10.1136\/bmj.h2102","article-title":"Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study","volume":"350","author":"Desai","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2020.10.030_bib9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1377\/hlthaff.2019.00814","article-title":"Neonatal abstinence syndrome in the United States, 2004-16","volume":"39","author":"Leech","year":"2020","journal-title":"Health Aff (Millwood)"},{"key":"10.1016\/j.jpeds.2020.10.030_bib10","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa055202","article-title":"Major congenital malformations after first-trimester exposure to ACE inhibitors","volume":"354","author":"Cooper","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2020.10.030_bib11","doi-asserted-by":"crossref","first-page":"e20174183","DOI":"10.1542\/peds.2017-4183","article-title":"Positive predictive value of administrative data for neonatal abstinence syndrome","volume":"143","author":"Maalouf","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2020.10.030_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1542\/hpeds.2016-0218","article-title":"Male sex associated with increased risk of neonatal abstinence syndrome","volume":"7","author":"Charles","year":"2017","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jpeds.2020.10.030_bib14","series-title":"Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis","author":"Harrell","year":"2001"},{"key":"10.1016\/j.jpeds.2020.10.030_bib15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41409-019-0679-x","article-title":"Cubic splines to model relationships between continuous variables and outcomes: a guide for clinicians","volume":"55","author":"Gauthier","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jpeds.2020.10.030_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1542\/hpeds.2018-0227","article-title":"Increased severity of neonatal abstinence syndrome associated with concomitant antenatal opioid and benzodiazepine exposure","volume":"9","author":"Sanlorenzo","year":"2019","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jpeds.2020.10.030_bib17","author":"Harrell"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2020.10.030_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1360-0443.2012.04038.x","article-title":"Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication","volume":"107","author":"Kaltenbach","year":"2012","journal-title":"Addiction"},{"key":"10.1016\/j.jpeds.2020.10.030_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1176\/appi.ps.201300235","article-title":"Medication-assisted treatment with methadone: assessing the evidence","volume":"65","author":"Fullerton","year":"2014","journal-title":"Psychiatr Serv"},{"key":"10.1016\/j.jpeds.2020.10.030_bib20","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/AOG.0b013e318256496e","article-title":"ACOG Committee Opinion No. 524: opioid abuse, dependence, and addiction in pregnancy","volume":"119","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2020.10.030_bib21","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1056\/NEJMsa1500439","article-title":"Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs","volume":"372","author":"Tolia","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2020.10.030_bib22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1542\/hpeds.2015-0024","article-title":"Risk of hospital readmission among infants with neonatal abstinence syndrome","volume":"5","author":"Patrick","year":"2015","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.jpeds.2020.10.030_bib23","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1056\/NEJMoa1005359","article-title":"Neonatal abstinence syndrome after methadone or buprenorphine exposure","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234762031297X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234762031297X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:06:44Z","timestamp":1758359204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234762031297X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":22,"alternative-id":["S002234762031297X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2020.10.030","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and Validation of a Model to Predict Neonatal Abstinence Syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2020.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}